The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells

Yao, Hong-Juan; Zhang, Yingge; Sun, Li; Liu, Yan

doi:10.1016/j.biomaterials.2014.07.033

Cited by 128 publications

(85 citation statements)

References 41 publications

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“…The DL coefficient and the encapsulation efficiency were calculated from the DOX concentration in the supernatant, using formulae (1) and (2), as given below. 33 The ACNP-DOX was freeze-dried and stored at -20°C until required for further use.…”

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confidence: 99%

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CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells

Jiang¹,

Wang²,

Zhang³

et al. 2016

IJN

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confidence: 99%

“…33 The suspension stability of ACNP, ACNP-DOX, ACNP-DSPE-PEG2000, ACNP-DOX-DSPE-PEG2000 and the NDDS, ACNP-DOX-DSPE-PEG2000-anti-CD20 in PBS (10 mM, pH 7.4) were observed by mixing 1 mg of corresponding preparation in 2 mL of PBS, followed by sonication for 30 minutes at room temperature.…”

mentioning

confidence: 99%

CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells

Jiang¹,

Wang²,

Zhang³

et al. 2016

IJN

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“…Yao et al used a combination of single walled carbon nanotubes (SWNT) used as targeting drug delivery system, salinimycin (SAL) used as an anti-cancer agent and hyaluronic acid (HA) used as targeting ligand in order to treat the gastric cancer stem cell and found productive result that helps to minimize the movement and intrusion of gastric cancer stem cell as well as eradication of it [25]. In another study combinations of neem and silver nanoparticles were used gastric cancer cells in vitro.…”

Section: Nanoparticles In Gastric Cancer Treatmentmentioning

confidence: 99%

Nanoparticles to Deal with Gastric Cancer

Kuddus¹

2017

J Gastrointest Cancer Stromal Tumor

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Nanomedicine has become a comprehensive field of medical science since the invention of nanoparticles namely nanotechnology. Uses of nanocarrier ease the way to deliver drugs more easily to deal with deadly diseases like cancer. Gastric cancer, another common form of cancer worldwide has little treatment option which makes it dangerous to deal with. Use of nanoparticles could boost up the process of developing new drugs in order to deal with this life threatening disease.

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“…Yao et al developed a highly specific gastric cancer stem cell (CSC)-targeting drug delivery system based on single-wall carbon nanotubes (SWNTs), which could selectively and effectively eliminate gastric CSCs. 25 correspondence: Qi-long Wang Department of clinical Oncology, huai'an Key laboratory of esophageal cancer Biobank and Department of central laboratory, huai'an First People's hospital, Nanjing Medical University, 6 W Beijing road, huai'an 223300, china Tel +86 158 6171 0352 email qlwang@njmu.edu.cn Pérez-Martínez et al reported that the docetaxel-mediated cytotoxicity in human prostate cancer cells dramatically increased by conjugating the cofilin-1 siRNA with CNHs. 26 Cao et al developed an innovative carrier for miRNA-203 delivery in esophageal cancer cells using protamine sulfate (PS)-nanodiamond (ND) nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

Zhang¹,

Yao²,

Wei³

et al. 2017

IJN

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Low toxicity and high efficacy are the key factors influencing the real-world clinical applications of nanomaterial-assisted drug delivery. In this study, novel hollow carbon spheres (HCSs) with narrow size distribution were developed. In addition to demonstrating their ease of synthesis for large-scale production, we also demonstrated in vitro that the HCSs possessed high drug-loading capacity, lower cell toxicity, and optimal drug release profile at low pH, similar to the pH in the tumor microenvironment. The HCSs also displayed excellent immunocompatibility and could rapidly distribute themselves in the cytoplasm to escape lysosomal clearance. More importantly, the HCSs could efficiently deliver doxorubicin (a representative chemotherapeutic drug) to tumor sites, which resulted in significant inhibition of tumor growth in an esophageal xenograft cancer model. This also prolonged the circulation time and altered the biodistribution of the drug. In conclusion, this study revealed a novel drug delivery system for targeted tumor therapy.

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The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells

Cited by 128 publications

References 41 publications

CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells

CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells

Nanoparticles to Deal with Gastric Cancer

Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

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