The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis Patients

Mohammad, Chenar A.; Mirza, Barzan Abdulwahab; Mahmood, Zainab Salim; Zardawi, Faraedon M.

doi:10.3390/gels9040325

Cited by 7 publications

(1 citation statement)

References 44 publications

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“…Polysaccharide-based biomaterials have garnered significant attention and research, owing to their excellent biocompatibility [11], biodegradability, low toxicity, and renewable prospects. Hyaluronic acid (HA), an acidic mucopolysaccharide with potent antioxidant, gelling, anti-inflammatory, and wound-healing properties, is ideally suited for use in the pharmaceutical and personal care industries [12]. For example, Xia [13] cross-linked HA with CMSS via the Schiff base reaction to form a biocompatible hydrogel adhesive for hemostasis.…”

Section: Introductionmentioning

confidence: 99%

Structures, Properties, and Bioengineering Applications of Alginates and Hyaluronic Acid

et al. 2023

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In recent years, polymeric materials have been used in a wide range of applications in a variety of fields. In particular, in the field of bioengineering, the use of natural biomaterials offers a possible new avenue for the development of products with better biocompatibility, biodegradability, and non-toxicity. This paper reviews the structural and physicochemical properties of alginate and hyaluronic acid, as well as the applications of the modified cross-linked derivatives in tissue engineering and drug delivery. This paper summarizes the application of alginate and hyaluronic acid in bone tissue engineering, wound dressings, and drug carriers. We provide some ideas on how to replace or combine alginate-based composites with hyaluronic-acid-based composites in tissue engineering and drug delivery to achieve better eco-economic value.

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Section: Introductionmentioning

confidence: 99%

Structures, Properties, and Bioengineering Applications of Alginates and Hyaluronic Acid

et al. 2023

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Repeated local delivery of hyaluronic acid gel as adjunctive treatment of residual pockets in periodontitis patients undergoing supportive periodontal care. A randomized controlled clinical trial

Bertl,

Vlachou,

Pandis

et al. 2024

Clin Oral Invest

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Objectives To assess the effect of hyaluronic acid (HyA) application as adjunct to re-instrumentation of residual pockets in patients undergoing regular supportive periodontal care (SPC). Methods Chronic periodontitis patients (stage III and IV, grade B and C) with 4 interproximal residual pockets were randomly assigned to the test (HyA gel) or control (saline) group. After subgingival instrumentation, test or control substance was applied subgingivally, then daily supragingivally for 3 months, and if required a second time after subgingival re-instrumentation after 3 months. Clinical and patient reported outcome parameters were recorded every 3 months for 12 months. Pocket closure [probing pocket depth (PPD) ≤ 4mm with absence of bleeding on probing (BoP) at PPD = 4mm] was the main outcome parameter. Results Fifty-six patients (221 experimental sites) were analysed. Pocket closure was achieved in 56.8 and 46.6% of the experimental sites in the test and control group, respectively (p > 0.05), while median PPD and PPD distribution (< 5mm/5mm/ > 5mm) differed significantly between groups in favour of the test group, at 12 months. Further, significantly fewer sites in the HyA group required re-instrumentation at 3 months, and sites in the HyA group showed a tendency for lower odds to remain diseased compared to the control group (OR 0.48, 95%CI 0.22–1.06). The odds for a site to remain diseased after 12 months increased significantly in the presence of plaque (OR 7.94, 95%CI 4.12–15.28), but in general, decreased significantly over time (OR 0.48, 95%CI 0.28–0.81). Conclusion Re-instrumentation of residual pockets in SPC patients, per se, leads to a significant increase in pocket closure over time; this was impeded by poor plaque control. Repeated local application of HyA results in fewer sites requiring re-instrumentation and might slightly improve the rate of pocket closure. (clinicaltrials.gov registration nr. NCT04792541). Clinical relevance HyA gel is easy to apply, well accepted by patients, and may have some positive effect in terms of fewer sites requiring re-instrumentation at 3 months and higher pocket closure rate at 12 months.

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Factorial design of in situ gelling two-compartment systems containing chlorhexidine for the treatment of periodontitis

Ashfaq,

Sisa,

Kovács

et al. 2023

European Journal of Pharmaceutical Sciences

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The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis Patients

Cited by 7 publications

References 44 publications

Structures, Properties, and Bioengineering Applications of Alginates and Hyaluronic Acid

Structures, Properties, and Bioengineering Applications of Alginates and Hyaluronic Acid

Repeated local delivery of hyaluronic acid gel as adjunctive treatment of residual pockets in periodontitis patients undergoing supportive periodontal care. A randomized controlled clinical trial

Factorial design of in situ gelling two-compartment systems containing chlorhexidine for the treatment of periodontitis

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