The Effect of Hydro-Alcoholic Extract of Pumpkin Seeds on Estrogen Levels and Kidney Markers in Adult Female Rats

Jahromi, Samaneh Motamed; jahromi, sadegh niami

doi:10.5812/ircmj.98864

Cited by 2 publications

(2 citation statements)

References 53 publications

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“…It was possible to observe that AEG did not affect the structure of kidney tissue such as Bowman's capsule. According to the literature, there are some factors that influence the toxicity of chemical compounds in renal functions, for example, shape and activity of chemicals, effective dose, distribution, and excretion of compounds, among others(Motamed Jahromi & Niami Jahromi, 2020) Somchit et al (2014).…”

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confidence: 99%

Aqueous extract ofPaullinia cupanaattenuates renal and hematological effects associated with ketoprofen

et al. 2020

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This study aimed to evaluate the effect of aqueous extract of Paullinia cupana (AEG) against ketoprofen side effects, through biochemical, hematological, and histological parameters. AEG showed antioxidant activity in the DPPH • scavenging (IC 50 = 17.00 ± 1.00 µg/ml) and HPLC analysis revealed that this extract is constituted by antioxidants (caffeine, catechins, theobromine, and polyphenols). In vivo experiments in female Wistar rats demonstrated that alterations in urea, creatinine, and uric acid levels promoted (p < .05) by ketoprofen were reversed when AEG was co-administered. Ketoprofen significantly decreased the catalase levels of animal tissues (p < .05), which were restored when AEG was co-administered with the mentioned drug. Histological analysis showed that AEG protected tissues from damages caused by ketoprofen. Moreover, AEG reestablished the number of white blood cells, which had decreased when ketoprofen was administered. In conclusion, this study suggested that the association between ketoprofen and AEG may be an alternative to reduce health damages caused by this drug. Practical applications Paullinia cupana, popularly known as guaraná, is commonly consumed as a beverage in Brazil and exhibits pharmacological and beneficial effects to humans. Ketoprofen is an efficacious drug employed in the treatment of inflammatory processes. However, this drug can cause several side effects in humans. Thus, the usage of natural products and plant extracts that can reduce such undesirable effects consists in a valuable strategy to be applied in therapeutic interventions.

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confidence: 99%

Aqueous extract ofPaullinia cupanaattenuates renal and hematological effects associated with ketoprofen

et al. 2020

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“…As liver tissue is damaged by alternative synthetic estrogen replacement hormone therapy, pumpkin seeds appear to be a viable alternative to hormone therapy for women (Lestari & Meiyanto, 2018). Animal studies with hydroalcoholic extracts of pumpkin seeds showed their beneficial effects on ovulation without damaging liver or kidney tissues (Motamed‐Jahromi & Niami‐Jahromi, 2019; Motamed‐Jahromi & Niami, 2020).…”

Section: Biological Activitymentioning

confidence: 99%

The potential of pumpkin seed oil as a functional food—A comprehensive review of chemical composition, health benefits, and safety

Šamec

Loizzo

Gortzi

et al. 2022

Comp Rev Food Sci Food Safe

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The growing interest in foods that can be beneficial to human health is bringing into focus some products that have been used locally for centuries but have recently gained worldwide attention. One of these foods is pumpkin seed oil, which has been used in culinary and traditional medicine, but recent data also show its use in the pharmaceutical and cosmetic industries. In addition, some sources refer to it as a potential functional food, mainly because it is obtained from pumpkin seeds, which contain many functional components. However, the production process of the oil may affect the content of these components and consequently the biological activity of the oil. In this review, we have focused on summarizing scientific data that explore the potential of pumpkin seed oil as a functional food ingredient. We provide a comprehensive overview of pumpkin seed oil chemical composition, phytochemical content, biological activity, and safety, as well as the overview of production processes and contemporary use. The main phytochemicals in pumpkin seed oil with health‐related properties are polyphenols, phytoestrogens, and fatty acids, but carotenoids, squalene, tocopherols, and minerals may also contribute to health benefits. Most studies have been conducted in vitro and support the claim that pumpkin seed oil has antioxidant and antimicrobial activities. Clinical studies have shown that pumpkin seed oil may be beneficial in the treatment of cardiovascular problems of menopausal women and ailments associated with imbalance of sex hormones.

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The Effect of Hydro-Alcoholic Extract of Pumpkin Seeds on Estrogen Levels and Kidney Markers in Adult Female Rats

Cited by 2 publications

References 53 publications

Aqueous extract ofPaullinia cupanaattenuates renal and hematological effects associated with ketoprofen

Aqueous extract ofPaullinia cupanaattenuates renal and hematological effects associated with ketoprofen

The potential of pumpkin seed oil as a functional food—A comprehensive review of chemical composition, health benefits, and safety

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