The effect of hydroalcoholic extract of <em>Teucrium polium L.</em> on the inflammatory markers and lipid profile in hypercholesterolemic rats

Abstract

BackgroundCardiovascular diseases are among the most common causes of mortality worldwide. Therefore, it is necessary to control the risk factors of these patients. Since the level of inflammatory markers and lipid profiles has increased in cardiovascular diseases and due to the increasing role of plants in the treatment of diseases, the current study aimed to investigate the effect of hydroalcoholic extract of Teucrium polium on inflammatory markers and lipid profile in hypercholesterolemic rats.Materials and methodsA total of 24 adult male Wistar rats were randomly divided into four groups of six each and treated with oral administration for 8 weeks. The control group received normal diet, the sham group received high-cholesterol diet and experimental groups 1 and 2 received high-cholesterol diet in the 8 weeks and doses of 85 and 170 mg/kg, respectively, of the T. polium hydroalcoholic extract (TPHAE) in the second 4 weeks. At the beginning and the end of the study, rats were examined for biochemical parameters. The mean level of variables for each group was presented as mean ± standard error of mean.ResultsThe results of this study showed that, after administration of TPHAE, there was a significant decrease in the mean of inflammatory markers in all groups compared to sham group (P<0.001). Also, administration of the extract significantly reduced the serum levels of triglyceride, cholesterol and LDL-cholesterol and significantly increased the serum HDL-cholesterol levels. In addition, the 170 mg/kg dose of TPHAE was the most effective in reducing serum levels of inflammatory and lipid markers.ConclusionTreatment with TPHAE caused dose-dependent decrease in serum levels of inflammatory markers and lipid profile in hypercholesterolemic rats. Therefore, it can be applied as a natural product for the management of cardiovascular diseases.

Investigation of Antioxidant, Antifungal, Antibacterial, and Anti-inflammatory Effects of Teucrium polium on Common Pathogens in Vaginitis: A Review

“…This plant can be used as a natural remedy for managing cardiovascular diseases. A study conducted by Amraei et al showed that receiving 170 mg/kg of the hydroalcoholic extract of T. polium reduces serum levels of triglycerides, LDL-cholesterol, and cholesterol and increases serum levels of HDL-cholesterol (35). In a triple-blind study conducted on 70 women aged 20 to 30, results showed that oral administration of 250 mg of T. polium capsules every 6 hours during the first three days of menstruation resulted in a significant reduction in bleeding during menstruation (36).…”

Evaluation of Possible Antioxidant, Anti-Hyperglycaemic, Anti-Alzheimer and Anti-Inflammatory Effects of Teucrium polium Aerial Parts (Lamiaceae)

“…It is worth highlighting that water/ethanol is an effective solvent in extracting phytochemicals from the plant as it combines polar and medium polarity properties [ 60 ]. Thus, it appears that the anti-inflammatory effect of the extract may be due to the presence of flavonoids and phenolic compounds in the plant [ 54 , 61 ]. Cirsiliol has been reported to possess a potent and selective 5-lipoxygenase inhibitory potential that further consolidated the in silico studies [ 62 ].…”

Teucrium polium extract‐loaded solid lipid nanoparticles: A design and in vitro anticancer study

“…As shown in the results, TPE‐SLN effectively decreases the level of IL‐1b and IL‐6 in Ntra‐2 cells, which indicates the anti‐inflammatory effect of the formed nanoparticles. In some previous studies, the anti‐inflammatory effects of the T. polium have been investigated and confirmed by various methods (Amraei et al., 2018; Rahmouni et al., 2017). Similarly, in a study conducted in 2021, etofenamate and ibuprofen were loaded on SLNs to enhance the therapeutic effect in the topical treatment of inflammation and the anti‐inflammatory effect of the prepared nanoparticles was confirmed (Mancini et al., 2021).…”