The Effect of Hydroalcoholic Extract of Artemisia dracunculus L. (Tarragon) on Candida albicans Infection in Mice

Abstract

Background: Candida albicans, an opportunistic pathogen, causes disseminated infection in immunocompromised host. Artemisia dracunculus L. (Tarragon) is a plant used as meal and remedy for a long time, and possesses some medicinal characteristics. Its pharmacological properties have been shown in a large number of in-vitro and in-vivo studies. Objectives: Regarding the antifungal activity, widespread secondary metabolites, and proved biological activities of tarragon, this study aimed to investigate the effect of hydroalcoholic extract of A. dracunculus L. on C. albicans infection in mice. Methods: The mice were divided into six groups including a normal control group, a placebo group, and three treatment groups receiving 50, 100, and 200 mg/kg doses of hydroalcoholic extract via intraperitoneal (ip) injection followed by inoculation with C. albicans. A control + group, inoculated only with C. albicans, was also employed. After all treatments, the mice were killed by cervical

Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology

“…For the maximum dose of the extract -200 mg/kg, the concentration of the pathogen in the liver was 16.08 colony-forming units per gram of test material (CFU/g), and no traces of its presence were found in the kidneys. The amount in the control was 36.28 CFU/g and 53.31 CFU/g, respectively (Zarasvand et al, 2016).…”

Investigating the Polyphenolic Profile and the Antioxidant and Antibacterial Activity of Tarragon (Artemisia Dracunculus L) Cultivated in Central Romania

“…29,30,33,38,43.52-58 More than that, A. dracunculus L. has shown antifungal activity against certain fungal species, such as Candida albicans, Cryptococcus neoformans, Aspergillus niger, Microsporum canis, Trichophyton rubrum, Microsporum gypseum, and Fonsecaea pedrosol. [59][60][61]…”