2021
DOI: 10.18502/ijrm.v19i3.8575
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The effect of hydroalcoholic extract of Nigella Sativa seed on dehydroepiandrosterone-induced polycystic ovarian syndrome in rats: An experimental study

Abstract: Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women. Objective: The aim of this study was to investigate the therapeutic effect of hydroalcoholic extract of Nigella sativa (N. sativa) seed as a plant, the consumption of which has been recommended in Islam, on dehydroepiandrosterone (DHEA)-induced PCOS rats. Materials and Methods: This experimental study was carried out on 36 Wistar female rats (3 wk, 60 ± 10 gr). Then rats were divided into 6 group… Show more

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Cited by 15 publications
(12 citation statements)
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“…Various studies have shown that Nigella sativa extract due to the presence of phytoestrogenic and flavonoid compounds reduces the number of ovary cysts induced by exposure to estradiol valerate, letrozole, and dehydroepiandrosterone in different animal models (rats and mice) of PCOS. The extract of this plant has been suggested to improve PCOS by upregulating the mRNA expression of epigenetic‐related (Dnmt1 and Hdac1) and maternally derived genes (Mapk and Cdk1), reducing ROS, and affecting the HPG axis (i.e., suppressing LH and estrogen secretion and also boosting FSH levels) (Khani et al., 2021 ).…”
Section: Resultsmentioning
confidence: 99%
“…Various studies have shown that Nigella sativa extract due to the presence of phytoestrogenic and flavonoid compounds reduces the number of ovary cysts induced by exposure to estradiol valerate, letrozole, and dehydroepiandrosterone in different animal models (rats and mice) of PCOS. The extract of this plant has been suggested to improve PCOS by upregulating the mRNA expression of epigenetic‐related (Dnmt1 and Hdac1) and maternally derived genes (Mapk and Cdk1), reducing ROS, and affecting the HPG axis (i.e., suppressing LH and estrogen secretion and also boosting FSH levels) (Khani et al., 2021 ).…”
Section: Resultsmentioning
confidence: 99%
“…If there are any imbalances in these hormones PCOS may occurs. The most common signs and symptoms of PCOS are female infertility, menstrual irregularities, Type 2 diabetes, obesity etc... [3] Most commonly there are four types of PCOS they are:…”
Section: Introductionmentioning
confidence: 99%
“…Some plant products such as, Nigella seeds has been reported to influence hormonal levels in the body as well as other related functions of the endocrine system. Nigella seed extract contain thymoquinone have helped regulate testosterone, luteinizing and thyroid hormone levels and exhibit estrogenic activity [6] suggesting that nigella seeds can be used as an alternative to hormone replacement therapy during menopause. Also, 600mg of concentrated ashwagandha extract has been reported to daily improve thyroid stimulating hormones in Adults, while others reported its side effects [7].…”
Section: Introductionmentioning
confidence: 99%