The Effect of Hydrogen Peroxide in Human Internal Thoracic Arteries: Role of Potassium Channels, Nitric Oxide and Cyclooxygenase Products

Nacitarhan, Cahit; Bayram, Zeliha; Eksert, Bilsen; Usta, Coşkun; Golbasi, Ilhan; Özdem, Sebahat

doi:10.1007/s10557-007-6037-z

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…In contrast, Nacitarhan et al. [62] studied internal thoracic artery rings and found that authentic H 2 O 2 produced dose‐dependent relaxations that were blunted by 4‐aminopyridine, a voltage‐dependent potassium channel blocker. These contradictory results may reflect differences in the vascular beds and vasodilatory stimuli being studied.…”

Section: Role Of H2o2 In Endothelial Function In Humansmentioning

confidence: 99%

“…Although some reports describe H 2 O 2 as an EDHF in humans [53,58], others have offered conflicting evidence regarding the role of H 2 O 2 in mediating endothelium‐dependent vasodilation [12,30,32,44,53,57,62,69]. Hamilton et al.…”

Section: Role Of H2o2 In Endothelial Function In Humansmentioning

confidence: 99%

“…Although some reports describe H 2 O 2 as an EDHF in humans [53,58], others have offered conflicting evidence regarding the role of H 2 O 2 in mediating endotheliumdependent vasodilation [12,30,32,44,53,57,62,69]. Hamilton et al [30] reported that NO • ⁄ prostanoid-independent relaxation of human radial arteries to carbachol was resistant to treatment with either SOD or catalase, suggesting that this EDHF-like component of the endothelium-dependent response to carbachol was not mediated by H 2 O 2 .…”

Section: Role Of H 2 O 2 In Endothelial Function In Humansmentioning

confidence: 99%

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Redox Balance in the Aging Microcirculation: New Friends, New Foes, and New Clinical Directions

et al. 2011

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Cardiovascular aging is associated with a decline in the function of the vascular endothelium. Considerable evidence indicates that age-induced impairment of endothelium-dependent vasodilation results from a reduction in the availability of nitric oxide (NO ), and age-related increases in ROS have been demonstrated to contribute to reduced endothelium-dependent vasodilation in numerous large artery preparations. In contrast, emerging data suggest that ROS may play a compensatory role in endothelial function of the aging microvasculature. The primary goal of this review is to discuss reports in the literature which indicate that ROS function as important signaling molecules in the aging microvasculature. Emphasis is placed upon discussion of the emerging roles of hydrogen peroxide (H 2 O 2 ) and peroxynitrite (ONOO •)) in the aging microcirculation. Overall, existing data in animal models suggest that maintenance in the balance of ROS is critical to successful microvascular aging. The limited work that has been performed to investigate the role of ROS in human microvascular aging is also discussed, and the need for future investigations of ROS signaling in older humans is considered.Key words: microvasculature, reactive oxygen species, nitric oxide, hydrogen peroxide, peroxynitrite Abbreviations used: cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; EDHF, endotheliumderived hyperpolarizing factor; eNOS, endothelial nitric oxide synthase; H 2 O 2 , hydrogen peroxide; HIF-1a, hypoxia-inducible factor-1a; HO, hydroxyl radical; HO-1, heme oxygenase-1; l-NAME, l-nitro-arginine methyl ester; l-NNMA, l-NGmonomethyl arginine; NAD(P)H, nicotinamide adenine dinucleotide phosphate; NO, nitric oxide; NOS, nitric oxide synthase; NQO1, NAD(P)H:quinone reductase 1; Nrf2, nuclear factor (erythroid-derived 2)-related factor-2; O 2 , superoxide; ONOO, peroxynitrite; sGC(b)1, soluble guanylate cyclase (b)1 subunit; SOD, superoxide dismutase.

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Section: Role Of H2o2 In Endothelial Function In Humansmentioning

confidence: 99%

Section: Role Of H2o2 In Endothelial Function In Humansmentioning

confidence: 99%