The effect of hydroxyapatite nanoparticles on mechanical behavior and biological performance of porous shape memory polyurethane scaffolds

Yu, Juhong; Xia, Hong; Teramoto, Akira; Ni, Qing‐Qing

doi:10.1002/jbm.a.36214

Cited by 39 publications

(37 citation statements)

References 20 publications

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“…Composite scaffold bearing HAp NPs have shown different mechanical properties which mainly depend on the nature of composite and preparation method. Incorporation of HAp NPs has been reported to increase modulus of compression in the porous shape memory polyurethane (Yu et al, 2018) or enhance the ultimate compressive strength in PCL/poly(lactic-co-glycolic acid) (PLGA)/HAp NPs (Li X. et al, 2017). In another study compressive modulus of gelatin HAp NPs composite hydrogel has been shown to decrease by increasing the weight percentage of HAp NPs.…”

Section: Ceramic Nanoparticlesmentioning

confidence: 99%

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Fathi‐Achachelouei

Knopf‐Marques

Silva

et al. 2019

Front. Bioeng. Biotechnol.

290

146

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Advances in nanoparticle (NP) production and demand for control over nanoscale systems have had significant impact on tissue engineering and regenerative medicine (TERM). NPs with low toxicity, contrasting agent properties, tailorable characteristics, targeted/stimuli-response delivery potential, and precise control over behavior (via external stimuli such as magnetic fields) have made it possible their use for improving engineered tissues and overcoming obstacles in TERM. Functional tissue and organ replacements require a high degree of spatial and temporal control over the biological events and also their real-time monitoring. Presentation and local delivery of bioactive (growth factors, chemokines, inhibitors, cytokines, genes etc.) and contrast agents in a controlled manner are important implements to exert control over and monitor the engineered tissues. This need resulted in utilization of NP based systems in tissue engineering scaffolds for delivery of multiple growth factors, for providing contrast for imaging and also for controlling properties of the scaffolds. Depending on the application, materials, as polymers, metals, ceramics and their different composites can be utilized for production of NPs. In this review, we will cover the use of NP systems in TERM and also provide an outlook for future potential use of such systems.

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Section: Ceramic Nanoparticlesmentioning

confidence: 99%

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Fathi‐Achachelouei

Knopf‐Marques

Silva

et al. 2019

Front. Bioeng. Biotechnol.

290

146

View full text Add to dashboard Cite

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“…The apparent density and porosity of PU foam and PU-HA scaffolds were calculated by Equations (1) to (3). 21 Moreover, BET analysis (BEL, BELSORP MINI II) was performed to investigate the nanopores in the samples.…”

Section: Characterizationmentioning

confidence: 99%

“…The shifting of the peaks at 1012, 1223, and 3401 cm −1 in PU foam up to 1026, 1228 and 3409 cm −1 in PU-HA scaffolds, respectively, can be assigned to physical and/or chemical interactions [48][49][50] between HA and PU/ PU monomers ( Figure 5). Physical interaction may include hydrogen bonding between ─NH in urethane linkage, 17,21 and phosphate group and hydroxyl group in HA, hydrogen bonding between ether oxygen 51 in the soft segment F I G U R E 4 FTIR spectra of HA powder, PU foam and PU-HA scaffolds for a wavenumber region of (a) 400-4000 cm −1 , (b) 400-2000 cm −1 . FTIR, Fourier-transform infrared; PU, polyurethane [Color figure can be viewed at wileyonlinelibrary.com] (polyol) of PU and hydroxyl group in HA, metal affinity between ─C=O in urethane linkage and Ca 2+ in HA.…”

Section: Ftir Analysismentioning

confidence: 99%

“…18 Recently, HA/polymer bio-composite has been widely used in bone scaffolds for repairing/ replacement of bone tissues. [19][20][21] Up to now, PU-HA scaffolds have been fabricated through the addition of HA to the PU solution and using several techniques to generate pores in the scaffolds (such as electrospinning, 20 particle leaching, 21 etc. ), or mixing of HA with PU foam.…”

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confidence: 99%

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Three dimensional polyurethane/ hydroxyapatite bioactive scaffolds: The role of hydroxyapatite on pore generation

Nasrollah

Najmoddin

Mohammadi

et al. 2020

J of Applied Polymer Sci

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Fabrication of a suitable scaffold with highly interconnected and well-distributed pores for cell proliferation and growth in the field of bone tissue engineering is of high importance. In this study, three-dimensional porous polyurethane (PU) scaffolds, with 0, 15, 25, and 32 wt% hydroxyapatite (HA), were fabricated. In this regard, HA was incorporated into PU constituents prior to starting in-situ polymerization of PU. Porosity and density measurement of the scaffolds revealed that higher amount of HA in the scaffolds led to increasing the former and decreasing the latter quantity. The field emission scanning electron microscopy (FESEM) images revealed that by increasing HA content, the pore size showed a descending trend while the number of pores increased. This would be attributed to the type of interactions between HA and PU, and the role of HA in pore formation. Mechanical test revealed that Young's Modulus of the samples was reduced by increasing scaffold porosity caused by the increase of HA content. Bioactivity tests in the simulated body fluid (SBF) showed the ability of scaffolds forming apatite precipitates. MTT assay showed that by increasing HA content, MG63 osteoblast cell viability increased and FESEM images revealed proper attachment of the cells to the scaffold surface.

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“…Nano-hydroxyapatite (nHA) is the main inorganic calcium phosphate mineral component of bones and teeth. The close chemical similarity of nHA to natural bone has led to extensive research efforts to use synthetic nHA as a bone substitute [ [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. More than twenty years ago, Yamasaki et al showed that, after nHA ceramics were implanted into nonosseous sites of dogs for 3 months, the micropores of the porous nHA ceramics were found full of eosinophilic amorphous substance, suggesting a bone matrix [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of carbon nanotubes on osteogenic functions of adipose-derived mesenchymal stem cells in vitro and bone formation in vivo compared with that of nano-hydroxyapatite and the possible mechanism

Feng

Cao

et al. 2021

Bioactive Materials

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It has been well recognized that the development and use of artificial materials with high osteogenic ability is one of the most promising means to replace bone grafting that has exhibited various negative effects. The biomimetic features and unique physiochemical properties of nanomaterials play important roles in stimulating cellular functions and guiding tissue regeneration. But efficacy degree of some nanomaterials to promote specific tissue formation is still not clear. We hereby comparatively studied the osteogenic ability of our treated multi-walled carbon nanotubes (MCNTs) and the main inorganic mineral component of natural bone, nano-hydroxyapatite (nHA) in the same system, and tried to tell the related mechanism. In vitro culture of human adipose-derived mesenchymal stem cells (HASCs) on the MCNTs and nHA demonstrated that although there was no significant difference in the cell adhesion amount between on the MCNTs and nHA, the cell attachment strength and proliferation on the MCNTs were better. Most importantly, the MCNTs could induce osteogenic differentiation of the HASCs better than the nHA, the possible mechanism of which was found to be that the MCNTs could activate Notch involved signaling pathways by concentrating more proteins, including specific bone-inducing ones. Moreover, the MCNTs could induce ectopic bone formation in vivo while the nHA could not, which might be because MCNTs could stimulate inducible cells in tissues to form inductive bone better than nHA by concentrating more proteins including specific bone-inducing ones secreted from M2 macrophages. Therefore, MCNTs might be more effective materials for accelerating bone formation even than nHA.

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The effect of hydroxyapatite nanoparticles on mechanical behavior and biological performance of porous shape memory polyurethane scaffolds

Cited by 39 publications

References 20 publications

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Three dimensional polyurethane/ hydroxyapatite bioactive scaffolds: The role of hydroxyapatite on pore generation

The effect of carbon nanotubes on osteogenic functions of adipose-derived mesenchymal stem cells in vitro and bone formation in vivo compared with that of nano-hydroxyapatite and the possible mechanism

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