The effect of hydroxychloroquine on glucose control and insulin resistance in the prediabetes condition

Abstract

Background:Hydroxychloroquine can improve most underlying coronary risk factors; however, there are a few studies on the effects of hydroxychloroquine on blood glucose and insulin resistance. The current study aimed to assess the effects of hydroxychloroquine on blood glucose control status as well as on level of lipid profile and inflammatory biomarkers in prediabetic patients.Materials and Methods:In a randomized, double-blinded, controlled trial, 39 consecutive patients who were suffering from prediabetes and were referred to the Isfahan Endocrinology Center in January 2013 were randomly assigned to receive hydroxychloroquine (6.5 mg/kg/day) (n = 20) or placebo (n = 19) for 12 weeks. The biomarker indices and anthropometric parameters were tested before and after completion of treatment.Results:In both groups of patients receiving hydroxychloroquine and placebo, except for serum level of insulin that was significantly elevated after treatment by hydroxychloroquine, the changes in other parameters remained insignificant. Both groups experienced increase of insulin level, but this change was considerably higher in those groups receiving hydroxychloroquine. The group receiving hydroxychloroquine experienced reduction of glucose at 60 min of Oral Glucose Tolerance Test (OGTT) test after intervention, while the placebo group experienced increase of blood glucose at the same time.Conclusion:The use of hydroxychloroquine may increase the serum insulin level in patients with prediabetic states who are at risk of developing diabetes mellitus.

Cytotoxicity and in vitro evaluation of whey protein-based hydrogels for diabetes mellitus treatment

“…The combined CQP treatment was the least effective on the ACC-1 gene expression and it could be a condition where the effect of combining both drugs did not have a synergistic effect on the treatment. These findings confirm the possibility of CQ as an anti-obesity drug, which has been reported by other researchers [50], but the known side-effect, makes its use to be shunned.…”

Potential Effect of Hydroxychloroquine in Diabetes Mellitus: A Systematic Review on Preclinical and Clinical Trial Studies

“…HCQ can also minimize insulin postreceptor clearance and facilitate glucose transfer by insulin. Besides, this drug can suppress inflammatory biomarkers and control the lipid profile levels, resulting in a reduced risk of DM [17,18]. Furthermore, reduction in hemoglobin A1c (HbA1c) fasting plasma glucose (FPG) and postprandial blood glucose (PPBG) levels are established in various studies [17,[19][20][21][22].…”

Cardiovascular effects of hydroxychloroquine: a systematic review and meta-analysis

“…This beneficial effect of HCQ on lipid or glycaemic profiles seems to also exist in patients with lupus (14 studies3) or other conditions (diabetes: three studies4; obese non-diabetic patients: two studies5; and Sjögren syndrome: one study6). These interesting effects suggest there are other indications for HCQ use, including the prevention of recurrent cardiovascular events in patients with myocardial infarction, coronary artery disease or pre-eclampsia 7–9.…”