The Effect of Hyoscine N-Butyl Bromide Rectal on the Duration of Labour and Rate of Cervical Dilatation: A Systematic Review and Meta-Analysis

Larki, Mona; Rasti, Afarin; Makvandi, Somayeh

doi:10.1016/j.jogc.2023.102292

Journal of Obstetrics and Gynaecology Canada

2024

DOI: 10.1016/j.jogc.2023.102292

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The Effect of Hyoscine N-Butyl Bromide Rectal on the Duration of Labour and Rate of Cervical Dilatation: A Systematic Review and Meta-Analysis

Mona Larki,

Afarin Rasti,

Somayeh Makvandi

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Cited by 2 publications

References 17 publications

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Investigating the Effect of Hyoscine and Dexamethasone on Cervical Preparation in Primigravid Women with Term Pregnancy: A Double-blind Randomized Clinical Trial

Zoofaghari

Wong

Kiarasi

et al. 2023

Journal of Research in Pharmacy Practice

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Selective serotonin reuptake inhibitors (SSRIs) are widely used in the treatment of many types of mental disorders. Citalopram is commonly used as a new generation of SSRIs in this regard; however, unfortunately, its overdose is associated with seizure and heart disorders. The reported case in the present study indicated recurrent seizures, nonspecific ST-T changes, and prolonged QT interval due to the overuse of citalopram. The patient had bilateral anterior shoulder dislocation along with right proximal humerus fracture that was occurred during the seizure. The dislocation was initially reduced and then fixed. Moreover, the seizure was controlled with diazepam without any problems, and cardiac monitoring continued for 2 days. Massive citalopram overdose may be associated with recurrent seizures and QT prolongation. Complications postseizures, such as shoulder dislocations, should be examined for and managed appropriately.

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Investigating the Effect of Hyoscine and Dexamethasone on Cervical Preparation in Primigravid Women with Term Pregnancy: A Double-blind Randomized Clinical Trial

Zoofaghari

Wong

Kiarasi

et al. 2023

Journal of Research in Pharmacy Practice

View full text Add to dashboard Cite

show abstract

Investigating the Effect of Hyoscine and Dexamethasone on Cervical Preparation in Primigravid Women with Term Pregnancy: A Double-blind Randomized Clinical Trial

Shabanian,

Danesh,

Najafi

2023

Journal of Research in Pharmacy Practice

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Objective: Pregnancy outcomes are an important factor in women’s quality of life, and negative experiences have adverse effects on the overall health of the mother and the family. This study was designed and implemented to compare the effects of two drugs, hyoscine and dexamethasone, on cervical ripening and effacement during childbirth. Methods: This study was a double-blind randomized clinical trial of 150 patients divided into three groups. The researchers, in the early stage (latent) of labor, gave 8 mg of dexamethasone intravenously to the first group, 20 mg of hyoscine butyl bromide to the second group, and 8 mg of dexamethasone along with 20 mg of hyoscine butyl bromide to the third group. Findings: Among the quantitative variables studied (length of labor induction, duration of active stage, first stage and second stage of labor, placental expulsion time, 5- and 10-min Apgar and Bishop score), active stage duration (P = 0.000) and 5-min Apgar (P = 0.042) had statistical differences among the three groups. In addition, the type of delivery (P = 0.003) and the percentage of fetal distress (P = 0.001) in the studied groups had a statistically significant difference, and also, in the third group, the cesarean rate was less than the other two groups. Conclusion: Simultaneous injection of hyoscine and dexamethasone in primiparous women can reduce the duration of the active stage of labor without obstetric complications, so its use in the latent stage is suggested.

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The Effect of Hyoscine N-Butyl Bromide Rectal on the Duration of Labour and Rate of Cervical Dilatation: A Systematic Review and Meta-Analysis

Cited by 2 publications

References 17 publications

Investigating the Effect of Hyoscine and Dexamethasone on Cervical Preparation in Primigravid Women with Term Pregnancy: A Double-blind Randomized Clinical Trial

Investigating the Effect of Hyoscine and Dexamethasone on Cervical Preparation in Primigravid Women with Term Pregnancy: A Double-blind Randomized Clinical Trial

Investigating the Effect of Hyoscine and Dexamethasone on Cervical Preparation in Primigravid Women with Term Pregnancy: A Double-blind Randomized Clinical Trial

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