The effect of hyoscine N– butyl bromide on the duration of active phase of labor

Abstract

Background and objective: Hyoscine N-butyl bromide acts by inhibiting cholinergic transmission in pelvic parasympathetic ganglia and antagonizing muscarinic receptors of smooth muscles in the abdomen and pelvic organs, thus relieving spasm aiding to cervical dilation. This study is to assess the efficacy of Hyoscine butyl bromide on cervical dilation in multigravid pregnant women during the active phase of labor. Methods: A randomized clinical prospective trial was conducted in maternity hospital in Sulaimaniyah, from 1 st of January to the 1 st of July 2010. Women were consecutively randomized into: the study group (A) who received 40 mg Hyoscine N-butyl bromide by slow intravenous injection in the active phase of first stage of labor and the control group (B) who received 2ml of normal saline. Each group consists of 130 patients after excluding high risk pregnancy. Results: Mean duration of active phase of labor was 142.69 min, 258.00 min in group A and B, respectively (p-value < 0 .001). Mode of delivery and neonatal outcome were comparable. No adverse maternal or fetal effects were noted. Conclusion: Intravenous Hyoscine N-Butyl Bromide shortens the duration of active phase of labor without any unwanted fetal or maternal effects, also it effectively shortens the 2 nd and 3 rd stages of labor.

The effect of hyoscine n- butylbromide on labor progress: A systematic review

“…Eleven studies were excluded because of study design was different from our inclusion criteria and seven studies were excluded because of their comparators were different from the inclusion criteria of this review. In the search update on December 2nd 2019 four other studies were found [30][31][32][33] . Finally, 20 studies were included in the meta-analysis ( Fig.…”

“…The characteristics of the included studies are shown in Table 1. Six of the studies were conducted in Iran [19][20][21][22][23]35]; three in Egypt [16,18,36]; three in Nigeria [17,24,32]; two in Iraq [30,31] and one in each following countries: Saudi Arabia [34], West Indies Jamaica [14], Mexico [25], Turkey [10], Puducherry [33] and Pakistan [15]. All studies were performed in the hospital setting, mostly in university hospitals.…”

“…HBB was administered either intravenously (IV), intramuscularly (IM) or as a rectal suppository. In 14 studies HBB was administrated with dose of 20 mg [10, 14-17, 20, 21, 23-25, 31, 33, 35, 36], and in six studies HBB was administrated with dose of 40 mg [18,19,22,30,32,34]. In two studies, HBB was administrated on two occasions with an interval of 1 h or 4-6 h later [19,25].…”

“…Eight studies recruited primigravida women [16,18,[21][22][23][34][35][36]. Ten studies recruited primi-and multigravida women [10,14,15,17,19,24,25,[31][32][33] and two studies enrolled only multigravida women [20,30]. In four studies, the duration of the first stage of labor was reported separately by primi and multigravidas [10,[31][32][33].…”

“…All twenty studies, including 3180 participants, were sub-grouped by the gravidity of the participants. Eleven analysis was used and by eliminating of nine studies the level of heterogeneity was reduced to 44% (MD = − 47.80; 95% CI: [− 52.24, − 43.57], P = 0.04) [17,19,21,23,24,30,35]. In studies which did not distinguish between multigravida and primigravida, the effect was less than those only involving primi-or multigravida women.…”