The Effect of Hypercholesterolemia on Rotator Cuff Disease

Abboud, Joseph A.; Kim, Jae Seung

doi:10.1007/s11999-009-1151-9

Cited by 176 publications

(156 citation statements)

References 14 publications

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“…Other system diseases have been associated with rotator cuff tearing as well as rotator cuff healing. Abboud et al [38] collected serum cholesterol and lipid profiles on patients with full-thickness rotator cuff tears and compared them to a control population. They determined that total cholesterol, triglycerides and lowdensity lipoprotein cholesterol concentrations were higher in patients with rotator cuff tears.…”

Section: Muscle-tendon Unit Retractionmentioning

confidence: 99%

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Factors affecting healing after arthroscopic rotator cuff repair

Abtahi

Granger

Tashjian

2015

WJO

162

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Rotator cuff repair has been shown to have good longterm results. Unfortunately, a significant proportion of repairs still fail to heal. Many factors, both patient and surgeon related, can influence healing after repair. Older age, larger tear size, worse muscle quality, greater muscle-tendon unit retraction, smoking, osteoporosis, diabetes and hypercholesterolemia have all shown to negatively influence tendon healing. Surgeon related factors that can influence healing include repair construct-single vs double row, rehabilitation, and biologics including platelet rich plasma and mesenchymal stem cells. Double-row repairs are biomechanically stronger and have better healing rates compared with single-row repairs although clinical outcomes are equivalent between both constructs. Slower, less aggressive rehabilitation programs have demonstrated improved healing with no negative effect on final range of motion and are therefore recommended after repair of most full thickness tears. Additionally no definitive evidence supports the use of platelet rich plasma or mesenchymal stem cells regarding improvement of healing rates and clinical outcomes. Further research is needed to identify effective biologically directed augmentations that will improve healing rates and clinical outcomes after rotator cuff repair. Core tip: Many factors, both patient and surgeon related, can influence healing after repair. Older age, larger tear size, worse muscle quality, greater muscletendon unit retraction, smoking, osteoporosis, diabetes and hypercholesterolemia have all shown to negatively influence tendon healing after rotator cuff repair. Smoking cessation and blood glucose and cholesterol control are methods to potentially improve healing rates. Slower, less aggressive rehabilitation programs may improve healing rates with no negative effect on final range of motion and are therefore recommended after arthroscopic repair of most full thickness tears. Finally, no definitive evidence supports the use of platelet rich plasma or mesenchymal stem cells regarding improvement of healing rates after rotator cuff repair. Routine use of these adjuvants is therefore not currently recommended.

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Section: Muscle-tendon Unit Retractionmentioning

confidence: 99%

“…Smoking was detrimental to healing Ⅳ Chung et al [14] Retrospective cohort 408 pts/37.2 mo CT arthrogram, US Bone mineral density, as well as FI of the infraspinatus and amount of retraction, was an independent determining factor affecting postoperative rotator cuff healing Ⅲ Abboud et al [38] Case [53] RCT 201 pts/38.5 mo…”

Section: Mrimentioning

confidence: 99%

Factors affecting healing after arthroscopic rotator cuff repair

Abtahi

Granger

Tashjian

2015

WJO

162

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“…Many studies were conducted in older populations with at least one analysis group >50 years of age (33)(34)(35)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60). The range of symptom duration varied substantially within and across studies.…”

Section: Secondary Screen-quality Assessment Overviewmentioning

confidence: 99%

Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders

Gold¹,

Hallman²,

Hellström³

et al. 2015

Scand J Work Environ Health

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A statistically significant association between the musculoskeletal disorders (MSD) and biomarkers studied was demonstrated in 82% of sufficient quality articles. Evidence suggested that: collagen repair marker (TIMP-1) is decreased in fibroproliferative disorders; serotonin (5-HT) is increased in trapezius myalgia; triglycerides are increased in various MSD. Limitations in the articles include possible selection bias, confounding, spectrum effect, and insufficient attention to comorbid conditions.

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“…This study was performed in the western world and patients with rotator cuff tear were found to be hypercholesterolemic [4]. But there are no Indian studies done till now to find out Indian population also have cuff problem due to raised cholesterol.…”

Section: Introductionmentioning

confidence: 97%

“…Trauma and degenerative conditions can cause a tear [3]. Among rotator cuff group supraspinatus is most commonly found to involve [4]. Although degenerative tears are common [5], still exact cause is unclear.…”

Section: Introductionmentioning

confidence: 99%

Does Hypercholestolemia Predispose to Rotator Cuff Pathologies?

Kamath

2017

Asian J Pharm Clin Res

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Objective: Rotator cuff tear is one of the most common orthopedic musculoskeletal problem gaining importance due to large health scale expenditure. Causes of rotator cuff tears are multifactorial and unclear. The previous studies have suggested relation between elevated serum lipid profile and rotator cuff tear in the western population. We, therefore, undertook study in our Indian population to correlate the association of hypercholesterolemia with rotator cuff tear. Methods:After obtaining clearance from the Institutional Ethics Committee. We prospectively collected fasting lipid samples of the population who came to our hospitals with complaints of shoulder pain during our study period. 50 patients had rupture of rotator cuff which was confirmed by ultrasound of involved shoulder. 50 were seen for non-cuff related complaints. We followed strict inclusion and exclusion criteria.Results: Total cholesterol (TC), triglycerides, and low-density lipoprotein concentration of patients with rotator cuff tendon tear were on higher side than control group. High-density lipoprotein trend showed being lower than control group. 21 of 50 (42%) had high cholesterol (TC > 240 mg/dl) than compared to 18 of 50 (36%) in control group. However, p=0.539 and showed no statistical significance between groups Conclusion: In Indian population, there was no correlation between hypercholesterolemia and rotator cuff tear which is statistically significant.

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The Effect of Hypercholesterolemia on Rotator Cuff Disease

Abstract: Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.

Cited by 176 publications

References 14 publications

Factors affecting healing after arthroscopic rotator cuff repair

Factors affecting healing after arthroscopic rotator cuff repair

Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders

Does Hypercholestolemia Predispose to Rotator Cuff Pathologies?

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