The effect of hyperthermia on memory in rats

Misanin, James R.; Vonheyn, Robert E.; Bartelt, Scott W.; Boulden, William L.; Hinderliter, Charles F.

doi:10.3758/bf03326654

Cited by 20 publications

(12 citation statements)

References 23 publications

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“…EM (25) also showed a 2 8C increase in body core temperature because of EMW exposure. This interference with performance is consistent with previous reports on hyperthermia induced amnesia following exposure to hot water [Misanin et al, 1979;Mactutus et al, 1980;Rauch et al, 1989], behavioral perturbations produced by EMW induced hyperthermia [Hunt et al, 1975;de Lorge, 1984;Akyel et al, 1991;Mickley and Cobb, 1998], and suppressed performance of trained tasks in animals after absorption of electromagnetic energy caused hyperthermia in excess of 1-2 8C [Michaelson and Elson, 1996]. In part, hyperthermia might induce memory impairment by reducing the motivation for food [Hamilton, 1963] or by degrading attention span.…”

Section: Body Temperaturesupporting

confidence: 90%

1439 MHz pulsed TDMA fields affect performance of rats in a T‐maze task only when body temperature is elevated

Yamaguchi

Tsurita

Ueno

et al. 2003

Bioelectromagnetics

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This study sought to clarify the effects of exposure to electromagnetic waves (EMW) used in cellular phones on learning and memory processes. Sprague-Dawley rats were exposed for either 1 h daily for 4 days or for 4 weeks to a pulsed 1439 MHz time division multiple access (TDMA) field in a carousel type exposure system. At the brain, average specific absorption rate (SAR) was 7.5 W/kg, and the whole body average SAR was 1.7 W/kg. Other subjects were exposed at the brain average SAR of 25 W/kg and the whole body average SAR of 5.7 W/kg for 45 min daily for 4 days. Learning and memory were evaluated by reversal learning in a food rewarded T-maze, in which rats learned the location of food (right or left) by using environmental cues. The animals exposed to EMW with the brain average SAR of 25 W/kg for 4 days showed statistically significant decreases in the transition in number of correct choices in the reversal task, compared to sham exposed or cage control animals. However, rats exposed to the brain average SAR of 7.5 W/kg for either 4 days or for 4 weeks showed no T-maze performance impairments. Intraperitoneal temperatures, as measured by a fiber optic thermometer, increased in the rats exposed to the brain average SAR of 25 W/kg but remained the same for the brain average SAR of 7.5 W/kg. The SAR of a standard cellular phone is restricted to a maximum of 2 W/kg averaged over 10 g tissue. These results suggest that the exposure to a TDMA field at levels about four times stronger than emitted by cellular phones does not affect the learning and memory processes when there are no thermal effects.

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Section: Body Temperaturesupporting

confidence: 90%

1439 MHz pulsed TDMA fields affect performance of rats in a T‐maze task only when body temperature is elevated

Yamaguchi

Tsurita

Ueno

et al. 2003

Bioelectromagnetics

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“…An additional concern, generated by preliminary data, was to evaluate the generality of the stressor events that might disrupt an old reactivated memory. Since hyperthermia can have amnesic effects on retention (Jacobs & Sorenson, 1969;Kane & Jarvik, 1970;Mactutus, Ferek, & Riccio, 1980;Misanin, Vonheyn, Bartelt, Boulden, & Hinderliter, 1979), this agent was included in the design.…”

Section: Methodsmentioning

confidence: 99%

Hypothermia-induced amnesia for newly acquired and old reactivated memories: Commonalities and distinctions

et al. 1982

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A series of six experiments compared the characteristics of hypothermia-induced amnesia for newly acquired and old reactivated memories. Old memory, when reactivated by cue exposure, was disrupted by mild or deep hypothermia treatment, while new memory was impaired only by deep cooling. Mild hypothermia had no disruptive influence on either new or old memories. Old, but not new, learning showed recovery from amnesia in a ' test-retest procedure. The onset of amnesia was more rapid for an old reactivated memory than for a newly acquired memory. The susceptibility of memory to disruption decreased over time following original learning or cue reactivation, although this decrease was, if anything, more rapid following the cuing procedure. Recovery from amnesia could be induced by a recooling reminder treatment and was similar for both new and old memories. It was suggested that activity of, or access to, memory rather than age per se determines susceptibility to disruption. The process of memory reactivation appears somewhat more sensitive, rapid, and brief than the process(es) of memory formation. However, that the underlying old memory remains stable over time was supported by the strong retention when specific implicit or explicit reactivation cues were available. The temporal organization has long been held as an important dimension in the study of the diseases of memory. Since the late 19th century, when Ribot (1883) formulated his "law of regression," old memories have been viewed as more stable and less susceptible to disruption than recently acquired learning. However, since this rule was based on anecdotal and observational reports of human amnesia and senility, it is not surprising that the clinical literature suggests little agreement on the validity of Ribot's

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“…Because this functional relationship could not be attributed to noxious effects of the amnestic agent, the general paradigm quiekly attracted interest as a potent way to examine psychobiologieal processes in memory. In addition to ECS, such diverse agents as CO 2 (paolino, Quartermain, & Miller, 1966), Metrazol (Palfai & Chillag, 1971), some anestheties (Abt, Essman, & Jarvik, 1961;Cherkin, 1969), electrical stimulation of portions of the limbie system (Kesner & Doty, 1968;McDonough & Kesner, 1971), and both decreased (Beitel & Porter, 1968;Riecio, Hodges, & Randall, 1968) and elevated (Mactutus, Ferek, & Riecio, 1980;Misanin, Vonheyn, Bartelt, Boulden, & Hinderliter, 1979) body temperatures were among the treatments shown to produce timedependent memory loss. Although many of these treatments are potent stressors, it seems unlikely that stress per se is responsible for RA.…”

Section: Historical Overviewmentioning

confidence: 99%

“…The reversal of hyperthermiainduced retention loss was of particular interest because in other respects the amnesia resulting from hyperthermia appears to be unusually profound (cf. Misanin et al , 1979).…”

Section: Direct Challenges To the Consolidation Interpretation Of Amnmentioning

confidence: 99%

The status of memory following experimentally induced amnesias: Gone, but not forgotten

Riccio

Richardson

1984

Psychobiology

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Although the concept that information processing continues following the termination of a learning trial has long been represented in human research (e.g., "rehearsal"), it has only recently gained acknowledgement in studies of animal memory. An influential paper by McGaugh (1966) provided an important impetus in this direction by reviewing evidence that various posttrial manipulations could modulate retention. Thus, electroconvulsive shock (BCS) after training impaired memory, whereas strychnine administration enhanced it. Although McGaugh's (1966) specific interpretation was linked to a consolidation model of memory, the more general impact of his analysis may have been in calling attention to phenomena implying that the processing of information continues after the events constituting the nominallearning episode have ended. The notion of postacquisition processing has come to furnish a frame of reference for a variety of studies of animal memory (e.g., directed forgetting

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The effect of hyperthermia on memory in rats

Cited by 20 publications

References 23 publications

1439 MHz pulsed TDMA fields affect performance of rats in a T‐maze task only when body temperature is elevated

1439 MHz pulsed TDMA fields affect performance of rats in a T‐maze task only when body temperature is elevated

Hypothermia-induced amnesia for newly acquired and old reactivated memories: Commonalities and distinctions

The status of memory following experimentally induced amnesias: Gone, but not forgotten

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