The effect of hypothalamic peptides, neurohormone C and proline-rich peptide-1on the Ca2+-handling system in heartin pathophysiological conditions

Abstract

Institute of Biochemistry named after H. Buniatyan we discovered and studied hypothalamic peptides with coronary dilatory and antioxidant activities:neurohormone C (NC) and proline-rich peptide-1 (PRP-1). Both NC and PRP-1 exhibit cardioprotective effects, in part by restoring the calcium affinity for calcium-binding membrane proteins in cardiomyocytes. This affinity is diminished in the sarcoplasmic reticulum and mitochondriawith myocardial damage, heart failure, pancreatic necrosis and crush syndrome caused by isoproterenol. The peptides can also destroy the four detected toxic peptides and myocardial depressant factor, and protect against ischemiareperfusion injury. Further studies of these peptides may be promising for the treatment of patients at high risk of cardiovascular disease, regardless of pathology.

The Mechanism of Isoproterenol Hydrochloride-Induced Cardiac Arrhythmia and the Effect of Propranolol Through the CaMKII Pathway

“…VT is de ned as a sequence of a minimum of 4 consecutive ventricular premature beats (VPBs) [2] nonsustainable ventricular tachycardia (NSVT) was de ned as combining at least six non-driven consecutive VPBs and less than 15 VPBs (NSVT, 6 ≤ VPBs < 15). While ventricular tachycardia duration is greater than or equal to 15 VPBs (SVT, VPBs ≥ 15), it was de ned as sustained ventricular tachycardia (SVT) [17]. VT incidence was calculated Measurement ofcTnIlevels in serum Blood was collected from SD rats via femoral artery and left at room temperature for 2h.…”