1982
DOI: 10.1097/00006534-198210000-00006
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The Effect of Hypothermia and Tissue Perfusion on Extended Myocutaneous Flap Viability

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Cited by 35 publications
(20 citation statements)
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“…30 It is well known that hypothermia prolongs the critical ischemia time of muscle and musculocutaneous flaps. 9,[31][32][33][34][35] However, the present study showed no protective effect of hypothermic ischemia on inflammatory cytokine secretion following ischemiareperfusion injury compared with normothermic ischemia. Hypothermic ischemia reduces flap ischemic tissue damage by lowering the metabolic rate, 11 but no parameters could elucidate this antiischemic effect of hypothermia in the present study.…”
Section: Discussioncontrasting
confidence: 79%
“…30 It is well known that hypothermia prolongs the critical ischemia time of muscle and musculocutaneous flaps. 9,[31][32][33][34][35] However, the present study showed no protective effect of hypothermic ischemia on inflammatory cytokine secretion following ischemiareperfusion injury compared with normothermic ischemia. Hypothermic ischemia reduces flap ischemic tissue damage by lowering the metabolic rate, 11 but no parameters could elucidate this antiischemic effect of hypothermia in the present study.…”
Section: Discussioncontrasting
confidence: 79%
“…Several investigators studied continuous perfusion with various media, such as heparinised saline [8,15], Ringer solution [22], oxygenated fluorocarbon [28,31], plasma [25,26], Collins solution [15,17,29] or Ross solution [14]. Several investigators studied continuous perfusion with various media, such as heparinised saline [8,15], Ringer solution [22], oxygenated fluorocarbon [28,31], plasma [25,26], Collins solution [15,17,29] or Ross solution [14].…”
Section: Discussionmentioning
confidence: 99%
“…34,40 It can extend the viability of musculocutaneous flaps for up to 96 hours; however, intraarterial flushing with ice-cold modified Collins solution can further extend this time. 41 In 1992, Francel et al reported a 100 percent success rate when using such a technique during the closure of 80 patients with grade III open tibia-fibula fractures using free muscle transfers. However, this treatment is only applicable for muscle flaps and not other types of flaps with skin components, such as myocutaneous, fasciocutaneous, or perforator flaps.…”
Section: Hypothermia and Intraarterial Flushingmentioning
confidence: 99%