The effect of hypothermia on membrane lipids in rat neocortex

Kolomiytseva, I. K.; Markevich, L. N.; Perepelkina, N. I.; Ov, Bykova; Ignat’ev, D. A.; Фесенко, Е. Е.

doi:10.1134/s1607672909040152

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…In the hypothermic state, the proportion of phosphatidylinositol in the microsomal fraction decreases. In the nuclei of glial cells, the content of cholesterol and the ratio between cholesterol and phospholipids increases [70]. It has also been reported that hypothermia increases lipolysis, free fatty acid turnover rate and triglyceride/free fatty acid cycling in the human body so as to amplify the ability of stored triglycerides to react quickly to major changes in energy expenditure induced by a sustained cold environments [71].…”

Section: Pharmacological Targets For Drug Developmentmentioning

confidence: 99%

Molecular and Cellular Pathways as a Target of Therapeutic Hypothermia: Pharmacological Aspect

Han¹,

Park²,

Kim³

et al. 2012

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Induced therapeutic hypothermia is the one of the most effective tools against brain injury and inflammation. Even though its beneficial effects are well known, there are a lot of pitfalls to overcome, since the potential adverse effects of systemic hypothermia are still troublesome. Without the knowledge of the precise mechanisms of hypothermia, it will be difficult to tackle the application of hypothermia in clinical fields. Better understanding of the characteristics and modes of hypothermic actions may further extend the usage of hypothermia by developing novel drugs based on the hypothermic mechanisms or by combining hypothermia with other therapeutic modalities such as neuroprotective drugs. In this review, we describe the potential therapeutic targets for the development of new drugs, with a focus on signal pathways, gene expression, and structural changes of cells. Theapeutic hypothermia has been shown to attenuate neuroinflammation by reducing the production of reactive oxygen species and proinflammatory mediators in the central nervous system. Along with the mechanism-based drug targets, applications of therapeutic hypothermia in combination with drug treatment will also be discussed in this review.

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Section: Pharmacological Targets For Drug Developmentmentioning

confidence: 99%

Molecular and Cellular Pathways as a Target of Therapeutic Hypothermia: Pharmacological Aspect

Han¹,

Park²,

Kim³

et al. 2012

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Direct in vitro organogenesis from sprouted seeds of a highly economical and ecological valued tree, Korean pine

Liang

Bai

et al. 2021

Plant Cell Tiss Organ Cult

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The de novo organogenesis system for Korean pine of this economically and ecologically coniferous species was successfully established using sprouted seeds as the original explants. After 30 days of incubation, 92.67% of explants produced direct shoots on Gupta and Durzan(DCR) medium containing 2 mg • L −1 kinetin (KT) in combination 0.5 mg • L −1 thidiazuron (TDZ) with a maximum of about 15 shoots per explant respectively. We also confirmed the organogenic regeneration pattern by scanning electron microscopy (SEM) observation. For shoot elongation and growth after 60 days of culture, we obtained the highest mean length of 34.99 mm from DCR basal media supplemented with 6-benzyladenine (6-BA; 0.2 mg • L −1 ), 1-Naphthaleneacetic acid (NAA; 0.1 mg • L −1 ), and activated charcoal (AC; 1 g • L −1 ). The highest rooting percentages of 20.74-21.48% were observed within two months in the 1/2 DCR medium (major elements halved) enriched with 0.05 mg•L −1 NAA and 0.5 or 1 mg • L −1 indole-3-butyric acid (IBA).Rooted plants showed a survival rate of 90.28% in perlite: peat: vermiculite = 1:1:1 after acclimatization. This protocol is a successful and efficient biotechnological approach to the micropropagation of Korean pine, and these data will be helpful to the clonal propagation and conservation of Korean pine.

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Restoration of Vital Functions in Rats after Clinical Death Caused by Cold Water Submersion

Gagarinsky

Аверин

2021

BIOPHYSICS

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The effect of hypothermia on membrane lipids in rat neocortex

Cited by 4 publications

References 7 publications

Molecular and Cellular Pathways as a Target of Therapeutic Hypothermia: Pharmacological Aspect

Molecular and Cellular Pathways as a Target of Therapeutic Hypothermia: Pharmacological Aspect

Direct in vitro organogenesis from sprouted seeds of a highly economical and ecological valued tree, Korean pine

Restoration of Vital Functions in Rats after Clinical Death Caused by Cold Water Submersion

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