The effect of <i>Echinacea purpurea</i> (L.) Moench extract on experimental prostate hyperplasia

Skaudickas, Darijus; Kondrotas, Anatolijus Juozas; Kėvelaitis, Egidijus; Venskutonis, P. R.

doi:10.1002/ptr.2805

Cited by 10 publications

(9 citation statements)

References 7 publications

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“…Skaudickas et al (2003) observed significant elevation in the number of lymphocytes in rat receiving E. purpurea extract for at least 8 weeks. Improvement in feed conversion was reported by Maass et al (2005) in pig receiving E. purpurea cobs supplementation for at least two weeks.…”

Section: Introductionmentioning

confidence: 76%

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Enhancement of broiler performance and immune response by Echinacea purpurea supplemented in diet

Dehkordi¹,

Fallah²,

Dehkordi³

2011

Afr. J. Biotechnol.

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The objective of the present study was to compare short and long term application of Echinacea purpurea root powder on growth performance and immunity response of broiler chicks. Three replicate trials involving a total of 600 day-old Ross chicks were used in this study. In each trial, a total of 200 chicks were randomly allocated into 5 groups. Each group consisted of 4 pens with 10 chicks in each pen. The birds in group A received control mash diet during the experiment, but those in groups B and C were given control diet supplemented with 0.1% (w/w) and 0.5% (w/w) E. purpurea root powder, respectively. The chicks in groups D and E received control diet supplemented with 0.1% (w/w) and 0.5% (w/w) E. purpurea root powder, respectively, just for one week and fed control diet afterwards. The results showed that E. purpurea consumption for six weeks changed the total counts of white blood cells (WBCs), number of lymphocytes and heterophils, feed conversation ratio, and antibody titers against newcastle and avian influenza diseases (p < 0.05). In conclusion, this result suggests that feeding E. purpurea, particularly for long time, may improve feed conversion, change blood cells number and enhance immunity response in broilers.

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Section: Introductionmentioning

confidence: 76%

“…It could increase the number of lymphocytes too. However, elevation in the number of lymphocytes can be statistically reliable only if rats are fed Echinacea for at least eight weeks (Skaudickas et al, 2003). ND and AI HI-antibody titers were routinely examined to evaluate the effect of E. purpurea on humoral immune response of the chickens.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of broiler performance and immune response by Echinacea purpurea supplemented in diet

Dehkordi¹,

Fallah²,

Dehkordi³

2011

Afr. J. Biotechnol.

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“…Presently, phytotherapeutics has become popular in the treatment of BPH. Several plants, including Sphaeranthus indicus, Echinacea purpurea and Roystonea regia have been reported to possess anti-BPH potential (Skaudickas et al, 2009;Nahata and Dixit, 2011;Emeka and Obidoa, 2009). The employment of S. macrocarpon in ethnomedicine to manage inflammatory tumors motivated us to study its effects on BPH.…”

Section: Introductionmentioning

confidence: 99%

Prostate Specific Antigen, Antioxidant and Hematological Parameters in Prostatic Rats Fed Solanum macrocarpon L. Leaves

Iweala¹,

Ogidigo²

2014

Asian J. of Biological Sciences

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The effect of consumption of leaves of Solanum macrocarpon L. on the Prostate Specific Antigen (PSA) level, antioxidant status and hematological parameters in albino rats induced with Benign Prostate Hyperplasia (BPH) was studied. Twenty five animals divided into five experimental groups namely Normal Control group (NC-group), Benign Prostate Hyperplasia group (BPH-group), Finasteride-group, 5% Solanum macrocarpon-supplemented diet group (5% SMSD-group) and 10% SMSD-group were used in the study. The NC was not induced with BPH and fed a control diet (diet I). The BPH-group and Finasteride-group were induced with BPH but Finasteride-group was treated with finasteride and both were fed a control diet (diet I). Five percent SMSD-group and 10% SMSD-group were induced with BPH and fed with 5 and 10% S. macrocarpon-Supplemented Diet (SMSD), respectively. Benign prostate hyperplasia was induced in the animals by daily subcutaneous injections of Testosterone Propionate (TP) in olive oil for a period of 12 weeks and the animals were fed their respective diets throughout the duration. Parameters including Prostate Specific Antigen (PSA), hematological indices including hemoglobin and white blood cells in vivo antioxidant markers such as Superoxide Dismutase (SOD), Glutathione-S-Transferase (GST), glutathione (GSH) and catalase were determined. The histo-pathological changes of the prostate were also examined. The results showed that PSA levels decreased significantly (p<0.05) in groups fed with SMSD. Superoxide dismutase (SOD), Glutathione-S-Transferase (GST) and glutathione (GSH) levels increased significantly (p<0.05) while WBC were significantly decreased (p<0.05) in the groups fed SMSD. The histological studies showed a considerable improvement in the prostatic histo-architecture of the groups fed SMSD. These findings indicate that S. macrocarponsupplemented diets may prevent or suppress the development of BPH and be useful in its treatment and management.

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“…Among them, Serenoa repens [2930] Ganoderma lucidum ,[31] Lepidium meyenii (Red Maca),[32] banana peel,[33] and Echinacea purpurea [34] showed significant improvements of BPH. The results obtained in this study could have successfully presented that K. parviflora is a novel entry from Zigiberaceae plant and K. parviflora would be a promising candidate.…”

Section: Results and Methodsmentioning

confidence: 99%

Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome

Murata¹,

Hayashi²,

Matsumura³

et al. 2013

Phcog Res

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Background:Kaempferia parviflora rhizome is used as a folk medicine in Thailand for the treatment of various symptoms. In the present study, the inhibitory activities of extract from K. parviflora rhizome against 5α-reductase (5αR) were subjected. Furthermore, the effects of the extract from K. parviflorar hizome in benign prostate hyperplasia (BPH) were studied using the model mice.Materials and Methods:Preparations of extracts from the rhizomes of K. parviflora, Curcuma zedoaria and Zingiber officinale, and methoxyflavones isolated from K. parviflora was used for 5αR inhibition assay. The effects of K. parviflora extract on growth suppression for the prostates and seminal vesicles were performed based on the Hershberger's method. The K. parviflora extract was administered to castrated mice for 14 days.Results:K. parviflora extract showed more potent inhibitory activity on 5αR than C. zedoaria and Z. officinale extracts. The active principles were identified as 3,5,7,3’,4’-pentamethoxyflavone and 5,7,3’,4’-tetramethoxyflavone by activity guided fractionation. Furthermore, K. parviflora extract suppressed the weights of prostates and seminal vesicles in BPH model rats by daily administration for 14 days.Conclusion:These results indicate that K. parviflora extract can be a promising agent for the treatment of BPH.

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The effect of Echinacea purpurea (L.) Moench extract on experimental prostate hyperplasia

Cited by 10 publications

References 7 publications

Enhancement of broiler performance and immune response by Echinacea purpurea supplemented in diet

Enhancement of broiler performance and immune response by Echinacea purpurea supplemented in diet

Prostate Specific Antigen, Antioxidant and Hematological Parameters in Prostatic Rats Fed Solanum macrocarpon L. Leaves

Suppression of benign prostate hyperplasia by Kaempferia parviflora rhizome

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