The effect of <i>Helicobacter pylori</i> eradication on functional dyspepsia in Turkish children

Aksu, Aysel Ünlüsoy; Yılmaz, Güldal; Gürkan, Ödül Eğritaş; Sarı, Sinan; Dalgıç, Buket

doi:10.1111/hel.12497

Cited by 16 publications

(10 citation statements)

References 27 publications

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“…13 In another study conducted on 195 patients complaining of abdominal pain, H. pylori positivity was found to be 44.6% by gastric biopsy. 14 15 All these results were found to be lower than the results of our study, but they were conducted with a lower number of participants compared to our study.…”

Section: Discussioncontrasting

confidence: 93%

Screening of Helicobacter pylori in patients with dyspeptic complaints with the urea breath test and its usability in family medicine

Bayraktar

Dabak

2021

Turkish Journal of Family Medicine and Primary Care

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Objective: Helicobacter pylori (H.pylori) is a common cause of gastritis, peptic ulcer disease, gastric lymphoma, and gastric cancer. H.pylori positive in patients with dyspeptic complaints should be investigated in order to determine the etiology and reduce the risk of H.pylori-related malignancy. The urea breath test (UBT) is a simple, convenient, and highly accurate H.pylori screening test with excellent sensitivity and specificity. The utility of UBT as a screening test in family medicine was examined in this study, that investigated at H.pylori positive in patients with dyspeptic complaints. Method: A retrospective, cross-sectional, descriptive, single-center study was conducted. The results of the C14-UBT for H.pylori were investigated by scanning the archives of patients over the age of 18 who applied with dyspeptic complaints in an education and research hospital within a calendar year. In the evaluation of UBT results, ≥50cpm was considered positive, <25cpm negative, and 25-50cpm was considered suspicious. Results: The UBT findings of 1192 patients were included, with an acceptability rate of 83 percent. The average age of the participants was 48.7±15.3 years, with 61 percent of them being women and 39 percent being men. The UBT was 81.5cpm on average (IQR=214, min=0, max=909). According to the findings, 56 percent (n=667) of the participants tested positive for H.pylori, 43.2 percent (n=515) tested negative for H.pylori, and 0.8 percent (n=10) tested suspicious for H.pylori. Although 56.4 percent of women and 55.3 percent of males tested positive for H.pylori, there was no statistically significant difference (p>0.05). Conclusion: In this study conducted on a large group of patients, H.pylori positivity was found in 56% with the UBT. Considering this result, it has been evaluated that, in cases where the World Health Organization recommends H.pylori screening, and in patients with dyspeptic complaints but no alarm symptoms, H.pylori should be screened with urea breath test in Family Health Centers as an important preventive healthcare service.

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Section: Discussioncontrasting

confidence: 93%

Screening of Helicobacter pylori in patients with dyspeptic complaints with the urea breath test and its usability in family medicine

Bayraktar

Dabak

2021

Turkish Journal of Family Medicine and Primary Care

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“…While guidelines do not recommend H pylori eradication therapy unless there is a peptic ulcer, there are publications showing otherwise. In two studies conducted in children with recurrent abdominal pain 14 and functional dyspepsia 15 in Turkey, eradication of H pylori infection in these patient groups was found to increase the rate of clinical improvement. Similar to these studies, eradication of H pylori in children with dyspeptic symptoms was also shown to improve chronic dyspeptic symptoms in children in high‐income countries 16 .…”

Section: Discussionmentioning

confidence: 98%

Efficacy of a novel sequential treatment regimen containing bismuth forHelicobacter pylorieradication in Turkish children

2020

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Background Eradication rates of Helicobacter pylori (H pylori) with standard triple therapy are gradually decreasing all over the world, including in children, due to the development of strains resistant to antimicrobials. Sequential therapy can be used as an alternative method to increase eradication rates. Materials and Methods A total of 75 patients ≥ 8 years of age with H pylori gastritis were included in the study. According to Rome IV criteria, 38 patients had functional abdominal pain and dyspepsia, and 37 patients had alarm findings suggesting organic disease. Patients were treated with a novel sequential therapy consisting of the proton pump inhibitor (PPI)‐lansoprazole (1 mg/kg/day, maximum 30 mg daily), amoxicillin (50 mg/kg/d in two doses, maximum 2 × 1000 mg) for 7 days followed by PPI‐lansoprazole (1 mg/kg/d, maximum 30 mg daily), metronidazole (20 mg/kg/day in two doses, maximum 2 x 500 mg), tetracycline (50 mg/kg/d divided into four equal doses, maximum 4 x 500 mg), and bismuth subsalicylate (262 mg QID in patients ≤ 10 years of age, 524 mg QID in patients > 10 years of age in days 8‐14). Eradication status was evaluated by H pylori stool antigen test 8 weeks after the completion of treatment. Results The mean age of the patients was 15.1 ± 2.4 years and 51 (68%) were female. No patient discontinued therapy due to side effects. All patients had antral gastritis (76.0%) or pangastritis (24.0%). The peptic ulcer rate was 6.6%. Eradication therapy was given to all patients with or without peptic ulcer. H pylori eradication was achieved in 69 (92.0%) patients and symptoms improved in 61 of those eradicated. Conclusions As a first‐line treatment for H pylori eradication in children, administering a novel sequential therapy including bismuth for 14 days provides a high rate of eradication.

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“…H. pylori is believed to be infectious in children [ 21 ]. It is thought that if H. pylori is eradicated at a young age, reinfection is less likely to occur and eradication in children with dyspepsia has been shown to be effective in improving symptoms [ 22 ]. However, whether the test and treat approach in young asymptomatic patients suppresses the long-term development of gastric cancer has yet to be established.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Infection Mass Screening for Children and Adolescents: a Systematic Review of Observational Studies

Saito

Nishikawa

Masuzawa

et al. 2021

J Gastrointest Canc

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Purpose Population-based Helicobacter pylori (H. pylori) screening and eradication for adults in areas with a high incidence of gastric cancer have been shown to be effective. The current status of H. pylori screening for young people, however, has not been sufficiently evaluated. Methods A systematic review of population-based H. pylori screening of young people was performed using four databases (MEDLINE, EMBASE, the Cochrane Library, and ICHUSHI) and independently evaluated by two investigators. Studies were evaluated with regard to the country, region, screening method, target age, number of screened people, and rate of positive screening. Results From 3231 studies, 39 studies were included (14 English original studies published in peer-review journals, 6 Japanese original studies, and 19 conference reports). These studies originated from 10 countries, with the largest number stemming from Japan (29 studies) followed by Germany (2 studies). Screening was performed using the urea breath test, blood antibodies, stool antigens, and urine antibodies. Five countries used the breath test as the first screening method, five used blood samples, two used stool antigens, and only Japan used urinary tests. Conclusion Screening for H. pylori in young people was reviewed based on reports from several countries, and findings suggest that local authorities considering screening for H. pylori in young people need to scrutinize the age and potential methods. Further research is required to determine the effectiveness of mid- to long-term H. pylori screening for young people.

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The effect of Helicobacter pylori eradication on functional dyspepsia in Turkish children

Cited by 16 publications

References 27 publications

Screening of Helicobacter pylori in patients with dyspeptic complaints with the urea breath test and its usability in family medicine

Screening of Helicobacter pylori in patients with dyspeptic complaints with the urea breath test and its usability in family medicine

Efficacy of a novel sequential treatment regimen containing bismuth forHelicobacter pylorieradication in Turkish children

Helicobacter pylori Infection Mass Screening for Children and Adolescents: a Systematic Review of Observational Studies

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