The effect of <i>Nigella sativa</i> and <i>Eucheuma cottonii</i> in Collagen-induced Arthritis mice

Saidin, Khalimatun S.; Jais, Mohamad R.; Ismail, Elysha Nur; Ishak, Reezal

doi:10.5958/0974-360x.2020.00243.7

Cited by 6 publications

(2 citation statements)

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“…For example, NSO (1.82 mL/kg) reduced proinflammatory mediators (such as IL-6) and improved (56%) adjuvant induced-arthritis in the rat model [ 264 ]. Black cumin extract was supplemented in collagen-induced arthritis mice and exhibited a significant decrease in the inflammation score and neutrophil infiltration, exhibiting its anti-arthritic property [ 265 ]. The anti-arthritic effect of TQ (10 mg/kg in 0.1% DMSO) was observed in a rat model of arthritis with a marked reduction in the mRNA levels of toll-like receptor 2 (TLR2), TLR4, IL-1, NF-κB, and TNF-α [ 266 ].…”

Section: Benefits Of Black Cumin On Human Health and Disease Conditionsmentioning

confidence: 99%

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

et al. 2021

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Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The pleiotropic pharmacological effects of black cumin, and its main bioactive component thymoquinone (TQ), have been manifested by their ability to attenuate oxidative stress and inflammation, and to promote immunity, cell survival, and energy metabolism, which underlie diverse health benefits, including protection against metabolic, cardiovascular, digestive, hepatic, renal, respiratory, reproductive, and neurological disorders, cancer, and so on. Furthermore, black cumin acts as an antidote, mitigating various toxicities and drug-induced side effects. Despite significant advances in pharmacological benefits, this miracle herb and its active components are still far from their clinical application. This review begins with highlighting the research trends in black cumin and revisiting phytochemical profiles. Subsequently, pharmacological attributes and health benefits of black cumin and TQ are critically reviewed. We overview molecular pharmacology to gain insight into the underlying mechanism of health benefits. Issues related to pharmacokinetic herb–drug interactions, drug delivery, and safety are also addressed. Identifying knowledge gaps, our current effort will direct future research to advance potential applications of black cumin and TQ in health and diseases.

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Section: Benefits Of Black Cumin On Human Health and Disease Conditionsmentioning

confidence: 99%

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

et al. 2021

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“…It helps with digestion and parasite infections. It has been used to treat eczema, sores on the skin and has wound healing activity [5] . It has been observed that the seeds' various raw and purified components have a variety of pharmacologic effects, including antihistaminic [6] , antihypertensive [7] , hypoglycemic [8] , anti-inflammatory [9] , anti-neoplastic [10] , antibacterial [11] , antioxidant [12] , antifertility [13] etc.…”

Section: Introductionmentioning

confidence: 99%

Screening of Volatile Constituents of N. sativa on Calcium Depleted Heart Model

Chowdhury¹,

Majumdar²,

Roy³

et al. 2023

J. Res. Appl. Sci. Biotechnol.

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The number of deaths from cardiovascular disorders is rising every year. Nigella sativa, one of the accessible natural plants, has a broad range of pharmacological effects. The Nigella sativa seeds were removed, cleaned, and preserved in order to research the effects of the plant on the cardiovascular system. After being ground into a fine powder, the seeds were used to extract the volatile oil from the seeds using the steam distillation process. The hypodynamic model was used after the rat's heart was removed. Using the standard kreb's hanselet salt solution to mount the isolated heart, a typical graph was produced. As the calcium concentration was reduced, the graph's negative tropic activity became apparent. When N. sativa was administered it has produced additional negative tropic effect on hypodynamic heart. At 0.1 ml produced negative tropic effect and keeps on decreasing as the dose increases by 0.2, 0.4, 0.8ml in dose dependent manner.

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Neuroprotective effects of thymoquinone against MDMA-induced neurotoxicity

Mustafa

Mohamad

NH.

et al. 2021

RJPT

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MDMA (3, 4-methylenedioxymethamphetamine) is a psychoactive substance that is associated with neurotoxicity. MDMA exposure to human results in the degeneration of neuronal cells in the hippocampus. Hence, the purpose of this study was to examine the potential of a natural compound known as thymoquinone (TQ) to protect against neuronal damage and memory impairment in rats stimulated by MDMA. The administration of TQ into MDMA-induced neuronal damage rats was carried out in male Sprague Dawley via a 1-week treatment dividing into four groups (n=36, 7-9 per group). The studied groups involved with the treatments comprise i) Control (1 mL/kg saline), ii) MDMA (10 mg/kg MDMA), iii) MDMA+TQ (10 mg/kg MDMA + 40 mg/kg TQ) and iv) TQ control (40 mg/kg TQ). A novel object recognition test (NORT) was carried out to evaluate the memory performance of the rats, followed by a histopathological assessment of the hippocampal dentate gyrus. The histopathology analysis revealed a significant increase in numbers of positive cells by Fluoro-Jade C following the effect of MDMA on neuronal damage (MDMA induced group) compared to control (P<0.05). Next, the TQ treatments observed in MDMA+TQ exhibited a decline in positive cells from Fluoro-Jade C. The index of recognition memory was found to be increased in MDMA+TQ compared to the MDMA alone (P<0.05). This study suggests that the neuronal damage inflicted by MDMA in a rat model has the potential to be treated by TQ.

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The effect of Nigella sativa and Eucheuma cottonii in Collagen-induced Arthritis mice

Cited by 6 publications

References 0 publications

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

Screening of Volatile Constituents of N. sativa on Calcium Depleted Heart Model

Neuroprotective effects of thymoquinone against MDMA-induced neurotoxicity

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