The Effect ofO-(β-Hydroxyethyl)-Rutoside (HR) on Macromolecular Leakage, Thrombosis and Haemostasis in Experimental Animals

Abstract

O-(P-hydroxyethy1)-rtoside (HR) (Venoruton@, Zyma AS, Nyon, Switzerland) has been investigated experimentally to evaluate the effect on microvascular permeability and thromboembolism. Permeability to macromolecules is diminished in a hamster cheek-pouch model. Hsemostatic plug formation is impaired whereas laser-induced intravascular platelet aggregation is uninfluenced. There is a small but insignificant protection against sodium morrhuate (Eli Lilly and Co., Indianapolis, Indiana) induced femoral vein thrombosis.