The Effect of Immunization with Killed Tumor Cells, with/Without Feeding ofEchinacea purpureain an Erythroleukemic Mouse Model

Currier, Nathan; Miller, Sandra C.

doi:10.1089/107555302753507177

Cited by 27 publications

(19 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, during pregnancy, CD8+ T lineage lymphocytes express receptors for progesterone, and upon such activation, these cells secrete progesterone-induced blocking factor, which in turn, inhibits NK-cell-mediated cytolytic attack on the fetus [46][47][48] . The fact that lower numbers of normal fetuses were found throughout the middle stages of gestation (days 10-11; days [12][13][14] in the Echinacea -consuming pregnant mice suggests that the detrimental effect of Echinacea occurs early in pregnancy, again paralleling human pregnancies where the most sensitive phase for detrimental drug effects on the fetus occurs in the fi rst trimester.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Echinacea purpurea during Murine Pregnancy: Effect on Maternal Hemopoiesis and Fetal Growth

2006

View full text Add to dashboard Cite

Background: The medicinal benefits of Echinacea sp. plants in several disease conditions, including insect bites, respiratory ailments, and even cancer and AIDS, have been touted for decades. Echinacea sp.-based phytoceuticals are among the top selling herbals in the Western marketplace today. However, evidence is very scant concerning the effects of using Echinacea species herbals during pregnancy. While available data indicates that fetal malformations do not occur during pregnancy in humans consuming this herb, there are no formal studies aimed at assessing the possibility that consuming Echinacea herbals may promote spontaneous abortions, thereby reducing the number of live births upon which to assess the presence or absence of malformations. Objectives: We undertook a study in which pregnant mice were fed daily Echinacea purpurea from pregnancy onset until gestational days 10, 11, 12, 13, and 14. Methods: Maternal spleen and bone marrow were taken for enumeration of cells in each of five separate hemopoietic lineages/organ, and fetal status was recorded. Results: The data indicate that the significant, pregnancy-induced elevation in splenic lymphocytes and nucleated erythroid cells was all but eliminated in those females which consumed E. purpurea daily throughout their pregnancy. Moreover, consuming E. purpurea during pregnancy reduced the number of viable fetuses. Conclusions: The data may be extrapolated to suggest that in humans, abstention from consuming Echinacea products during the early/mid stages of pregnancy, may be prudent.

show abstract

Section: Discussionmentioning

confidence: 99%

“…We have recently shown, in vivo, that Echinacea, given to either normal, healthy adult mice, or to adult leukemic mice, signifi cantly increases the numbers of NK cells [10][11][12] . Primitive cells, such as stem cells and fetusassociated cells, are excellent targets for NK cells [13][14][15][16] .…”

mentioning

confidence: 99%

Dietary Echinacea purpurea during Murine Pregnancy: Effect on Maternal Hemopoiesis and Fetal Growth

2006

View full text Add to dashboard Cite

show abstract

“…et al, 2002;Raso et al, 2002). Furthermore, it is proven to enhance the immune response against tumor growth (Currier & Miller, 2002).…”

Section: Echinacea Species (Purple Coneflower American Coneflower)mentioning

confidence: 99%

A Review of Approaches Targeting the Replacement of Coccidiostat Application in Poultry Production

Barbour

Ayyash

Iyer

et al. 2015

Rev. Bras. Cienc. Avic.

View full text Add to dashboard Cite

The classical and the most commonly used approach for the prevention of coccidiosis in chickens is the incorporation of synthetic coccidiostats into their feed during the first weeks of their life. This approach has been challenged by consumers, objecting against residual antimicrobials and drug resistant microorganisms that may contaminate poultry products. Moreover, the coccidiostat application approach has been challenged in the last decade by the emerging regulations in the developed world, targeting the cessation of such a practice. The pressures from the consumers as well as from regulation agencies resulted in a great need for alternative methods to reduce, or completely replace the use of coccidiostats in modern chicken production. This replacement requires seeking for safer products that do not have any negative impact on the consumer's health. Such products are very much in demand, especially in organic poultry farming. The purpose of this review is to present approaches for the replacement of coccidiostat application in chickens through improvements in poultry house management, research in vaccine developments, and application of holistic natural products for the prevention of the economic losses resulting from coccidiosis.

show abstract

“…18 The E purpurea root extracts ingested by mice increased NK cell function in aged mice to levels found in young adult mice 19 and increased numbers of splenic NK cells in a mouse erythroleukemia model, resulting in a significantly increased life span. 20,21 In contrast to these studies, E purpurea juice given orally to healthy humans in a double-blind, placebocontrolled, crossover study 22 had no effect on phagocytic activity of polymorphonuclear lymphocytes (PMNLs) or macrophages and no effect on macrophage production of TNF-␣ or IL-1␤. A review 23 of 5 randomized studies that examined immunomodulatory effects of Echinacea on humans, as measured by phagocytic activity of PMNLs, reported that 2 studies showed significantly increased phagocytic activity, whereas the remaining studies showed no effect.…”

Section: Casementioning

confidence: 99%

Activation of Autoimmunity Following Use of Immunostimulatory Herbal Supplements

Lee¹,

Werth²

2004

Arch Dermatol

104

View full text Add to dashboard Cite

Background: Evidence for the scientific basis of purported therapeutic effects and adverse effects of herbal supplements continues to grow. Many herbal supplements are touted for their immunostimulatory properties, and both in vitro and in vivo experiments have supported this claim. Although this explains their beneficial effects in preventing or curtailing disease, to our knowledge, no immunostimulatory herbal supplements have been reported to exacerbate disorders of immune system overactivity.

show abstract

The Effect of Immunization with Killed Tumor Cells, with/Without Feeding ofEchinacea purpureain an Erythroleukemic Mouse Model

Abstract: The results demonstrate that combination therapy, involving specific tumor cell immunization, followed by daily phytotherapy (dietary E. purpurea), sensitized the immune cells and led to life span prolongation greater than that provided by immunization alone.

Cited by 27 publications

References 50 publications

Dietary <i>Echinacea purpurea</i> during Murine Pregnancy: Effect on Maternal Hemopoiesis and Fetal Growth

Dietary <i>Echinacea purpurea</i> during Murine Pregnancy: Effect on Maternal Hemopoiesis and Fetal Growth

A Review of Approaches Targeting the Replacement of Coccidiostat Application in Poultry Production

Activation of Autoimmunity Following Use of Immunostimulatory Herbal Supplements

Contact Info

Product

Resources

About