The Effect of Immunosuppression on Manifestations of Sepsis in an Animal Model of Cecal Ligation and Puncture

Kieslichova, Eva; Rocen, M; Merta, Dušan; Kudla, Michal; Šplı́chal, Igor; Cap, J.; Viklický, Ondřej; Gürlich, R

doi:10.1016/j.transproceed.2012.07.159

Cited by 13 publications

(8 citation statements)

References 43 publications

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“…While the breath and physiology data generated in this study are consistent with the literature, 14,15,32 one of the limitations of this study is that limited reliable data were obtained from blood samples. Blood cytokines (i.e.…”

Section: Discussionsupporting

confidence: 68%

The expired breath carbon delta value is a marker for the onset of sepsis in a swine model

Bütz

Morello

Sand

et al. 2014

J. Anal. At. Spectrom.

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Section: Discussionsupporting

confidence: 68%

The expired breath carbon delta value is a marker for the onset of sepsis in a swine model

Bütz

Morello

Sand

et al. 2014

J. Anal. At. Spectrom.

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“…In a recent study, a group of pigs were iatrogenically immunosuppressed with prednisone, cyclosporine, and mycophenolate and then underwent cecal ligation and puncture. This group exhibited a blunted pro-inflammatory IL-6 response and significantly increased anti-inflammatory IL-10 response compared to controls [6]. Elevated IL-10 levels have been associated with increased mortality after S. aureus bacteremia [33] and among general populations with sepsis [34].…”

Section: Discussionmentioning

confidence: 89%

Immune Dysfunction Prior to Staphylococcus aureus Bacteremia Is a Determinant of Long-Term Mortality

et al. 2014

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PurposeThe clinical implications for patients who survive serious infections are not well understood. It has been hypothesized that the excess mortality for survivors of sepsis observed in epidemiological studies is due to increased vulnerability to subsequent infections. We undertook this study to identify characteristics of patients who are at high risk for death after surviving a common type of blood-stream infection.Materials and MethodsAt a single academic medical center, 237 patients with Staphylococcus aureus bacteremia admitted during a three-year period were retrospectively identified. The primary outcomes were 30-day and 31 to 90-day mortality after the first positive blood culture. The primary predictor variable of interest was clinical immune dysfunction prior to bacteremia.ResultsThe 30-day mortality was not significantly different for patients with and without prior immune dysfunction. However, during days 31 to 90, 11 patients (20%) with prior immune dysfunction compared to 10 patients (8.6%) without prior immune dysfunction died (OR 2.59, 95% CI 1.03–6.53, p = 0.04). In a Cox-proportional hazard model controlling for age, there was a significant association between prior immune dysfunction and greater 31 to 90 day mortality (HR 2.44, 95% CI 1.01–5.90, p = 0.05) and a non-significant trend towards occurrence of subsequent infections and greater 31 to 90 day mortality (HR 2.12, 95% CI 0.89–5.07, p = 0.09).ConclusionsPatients with prior immune dysfunction are at high risk for death 31 to 90 days, but not <30 days, after S. aureus bacteremia. Further investigation is needed to determine if this finding is due to poor prognosis of chronic disease or increased vulnerability to subsequent infections.

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“…Only IL-6 and IL-10 showed significantly elevated values in the immunosuppressed group 24 hours after initiation of the hemodynamic event. 53,54 The subgroup of cancer patients has not yet benefited from some progresses in the approach of septic patients. The survival of cancer patients admitted to the ICU increased in recent years, 6,53 however, the understanding of the benefit of intensive therapy applied to them is controversial.…”

Section: Sepsis Biomarkers In Cancer Patientsmentioning

confidence: 99%

“…The progression of neoplasia and response to chemotherapy or radiotherapy does not seem to be associated with increased survival in short-term. 54…”

Section: Sepsis Biomarkers In Cancer Patientsmentioning

confidence: 99%

Sepsis in cancer patients admitted in the ICU: epidemiology, pathophysiology, and biomarkers

Ravetti¹,

Moura²,

Teixeira³

et al. 2014

Revista Médica De Minas Gerais

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Sepsis is one of the main causes of hospitalization in intensive care centers with high rates of morbidity and mortality. Its association with neoplasias has become a highlight due to increased use of propedeutics and interventional therapy that promotes breaking the barriers that protect the host and reduce physical bodily defenses favoring the host invasion by microorganisms. Little is known about these interrelationships. This review off of the MedLine database in interface with Pubmed aims to describe the epidemiology, pathophysiology, and biomarkers in oncology patients admitted in intensive care due to severe sepsis or septic shock. In septic patients without neoplasia, the association of different biomarkers has been the object of study of diagnosis, determination of severity, and outcome. In cancer patients, the biomarkers were primarily used in specific patient subgroups, such as neutropenics, with hematological disease, in order to determine infection. Further studies are required to know how the subgroups of patients with neoplasias behave and to understand and address more appropriately sepsis and septic shock.

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The Effect of Immunosuppression on Manifestations of Sepsis in an Animal Model of Cecal Ligation and Puncture

Cited by 13 publications

References 43 publications

The expired breath carbon delta value is a marker for the onset of sepsis in a swine model

The expired breath carbon delta value is a marker for the onset of sepsis in a swine model

Immune Dysfunction Prior to Staphylococcus aureus Bacteremia Is a Determinant of Long-Term Mortality

Sepsis in cancer patients admitted in the ICU: epidemiology, pathophysiology, and biomarkers

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