The effect of improved diabetic control on plasma lipid and lipoprotein levels: a comparison of conventional therapy and continuous subcutaneous insulin infusion

Pietri, A.; Dunn, F. L.; Raskin, Philip

doi:10.2337/diabetes.29.12.1001

Cited by 43 publications

(5 citation statements)

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“…It seems that in different settings such as screening, diagnosis and prediction of progression of diabetes we need to define different cut off points. [6] For example, It is suggested the value of 6.5% or greater as a diabetes diagnostic criterion and 6% and 4.7 for screening test. Inoue and his colleagues used the value of 5.8% for the prediction of progression of diabetes type 2, and the value <7 as a good predictive of satisfactory blood glucose control in type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

To Assess Correlation of Fasting Blood Glucose, Hb1Ac and Serum Lipid Level in Type II Diabetes Mellitus Patients

Chauhan¹,

Agrawal²

2019

AJM

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Background: Diabetes Mellitus (DM) refers to a group of common metabolic disorder that share the phenotype of hyperglycaemia caused due to either deficiency of insulin secretion or insulin resistance. The present study was conducted to assess correlation of fasting blood glucose, Hb1Ac and type II DM in given adults. Subjects and Methods: The present study was conducted on 134 patients with type II diabetes mellitus (DM) of both genders. Patients were subjected to estimation of fasting and random blood glucose level. Modified method of Fluckiger and Winterhalter was used for estimation of glycosylated haemoglobin (HbA1C). Results: Out of 134 patients, males were 84 and females were 50. Age group 20-30 years had 11, 30-40 years had 14, 40-50 years had 38, 50-60 years had 46 and >60 years had 25 patients. The mean fasting blood glucose level in patients with good degree of control was 106.2, in fair was 164.4 and in poor was 208.2. Glycosylated hemoglobin level was good (6.74), fair (8.12) and poor (12.54). A positive correlation of fasting blood glucose and glycosylated hemoglobin level and serum cholesterol & glycosylated hemoglobin level (P< 0.05) was found. Conclusion: Authors found a positive correlation of fasting blood glucose and glycosylated hemoglobin level and serum cholesterol & glycosylated hemoglobin level in type II diabetes mellitus patients.

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Section: Discussionmentioning

confidence: 99%

To Assess Correlation of Fasting Blood Glucose, Hb1Ac and Serum Lipid Level in Type II Diabetes Mellitus Patients

Chauhan¹,

Agrawal²

2019

AJM

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“…Glucocorticoids and insulin have proven to be modulators of apolipoproteins in vivo (Pietri et al, 1980;Henning, 1981;Staels et al, 1991), and in vitro (Elshourbagy et al, 1985a;Perrin-Ansart et al, 1988). Elshourbagy et al (1985a) and Staels et al (1989Staels et al ( , 1991 showed that both glucocorticoids and insulin enhanced the expression of apo A-I and apo A-IV whereas apo E was reported to be unresponsive to hormones.…”

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confidence: 99%

The Ontogeny of Apolipoprotein Expression in Rat Liver. mRNA Levels in Developing Liver and Cultured Fetal Rat Hepatocytes

1995

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“…Non-insulin-dependent (Type 2) diabetic patients are obese and obesity may lead to the development of hyperlipidemia. 17,18 The relationship between diabetes and hyperlipidemia is due to the unusually high prevalence of accelerated atherosclerosis in diabetic patients. [19][20][21] This is usually caused by the accumulation of very low-density lipoprotein (VLDL) and, rarely, chylomicrons in the plasma.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21] This is usually caused by the accumulation of very low-density lipoprotein (VLDL) and, rarely, chylomicrons in the plasma. [22][23][24][25] The aim of the present study was to evaluate the possible drug interactions in the prescribed combination therapy in a diabetic patient associated with hyperlipidemia using experimental animals (rats) and make researchers aware of them so as to prevent the occurrence/ reoccurrence of clinical adverse events. Another objective of the study is to provide a basic of drug interaction of widely used diabetes drug therapy, to young physicians and researchers.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Toxicity and Drug-Drug Interaction of Combination Therapy Prescribed by Physicians/ Clinicians for Treatment of Diabetes using Experimental Animals

Dewangan¹,

Tiwari²,

Sharma³

et al. 2021

IJPER

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Purpose: The management of diabetes associated with hyperlipidemia is a challenge not only to the physician but also to medical fraternity. Hence most of the physicians prefer to prescribe antihyperglycemic drug along with some lipid lowering agent. The present study is aimed to find out toxicity and drug interaction of combination therapy of hypoglycemic agents (Glimepride, Metformin) withhypolipidemic drugs (Atovastatin + Fenofibrate). Materials and Methods: Young healthy adult Albino Wister rats (150-180 g) were used in the study. The experimental animals we reassessed for acute toxicity study and ant diabetic activity. The drug-drug interaction was also evaluated by changes in physiological, hematological parameters and histopathology of different tissues. Results: The result of acute toxicity revealed that there was a change in body weight in the animal treated with hypoglycemic agents (Glimepride, Metformin) withhypolipidemic drugs (Atovastatin + Fenofibrate). Water, food consumption has not been varied with greater extent in all groups of animals. Mild changes were marked inhemoglobin, neutrophils,platelet count. Conclusion: The combination of drugs showed mild change in the effect of Glimepride + Metformin alone and in combination with Atorvastatin + Fenofibrate. Other factors showed no significant effect which proves that there is no drug interaction.

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The effect of improved diabetic control on plasma lipid and lipoprotein levels: a comparison of conventional therapy and continuous subcutaneous insulin infusion

Cited by 43 publications

References 0 publications

To Assess Correlation of Fasting Blood Glucose, Hb1Ac and Serum Lipid Level in Type II Diabetes Mellitus Patients

To Assess Correlation of Fasting Blood Glucose, Hb1Ac and Serum Lipid Level in Type II Diabetes Mellitus Patients

The Ontogeny of Apolipoprotein Expression in Rat Liver. mRNA Levels in Developing Liver and Cultured Fetal Rat Hepatocytes

Assessment of Toxicity and Drug-Drug Interaction of Combination Therapy Prescribed by Physicians/ Clinicians for Treatment of Diabetes using Experimental Animals

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