The effect of in vitro fertilization on birth rates in western countries

Habbema, J. Dik F.; Eijkemans, Marinus J.C.; Nargund, Geeta; Beets, G.C.N.; Léridon, Henri; Velde, Egbert R. te

doi:10.1093/humrep/dep004

Cited by 65 publications

(47 citation statements)

References 26 publications

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“…According to AR registries in European countries, between 0.5 percent (Turkey) and 4.6 percent (Denmark) of children born in 2008 were conceived via AR (Ferraretti et al 2012); the average for European countries with available data was 1.6 percent, comparable to the US (1.5 percent in 2009). Assisted reproduction has a very minor positive effect on aggregate fertility rates in rich countries , Habbema et al 2009ESHRE 2010) although its "net impact" is difficult to estimate as some of its users would otherwise achieve a spontaneous conception (Pinborg et al 2009). …”

Section: Fertility Postponement and Assisted Reproductionmentioning

confidence: 99%

Future Fertility in Low Fertility Countries

Basten

Sobotka

Zeman

et al. 2014

World Population and Human Capital in the Twenty-First Century

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Standard-Nutzungsbedingungen:Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden.Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen.Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen Nutzungsbedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Terms of use: Documents in Future Fertility in Low Fertility Countries AbstractThis paper discusses results of the global survey of experts on the future of low fertility in low-fertility countries. The survey was coordinated by the Wittgenstein Centre for Demography and Global Human Capital as a part of an effort to produce global argumentbased population projections by age, sex and level of education. First we give an overview of fertility changes in major low-fertility regions. Next we outline main theoretical arguments and review a wide range of factors contributing to fertility change and variation in contemporary low-fertility settings. Subsequently, we present survey results based on 184 assessments of over 170 experts analysing 41 countries with currently low or aroundreplacement fertility and Israel. These experts provided forecasts of period total fertility rate (TFR) in 2030 and 2050, estimated 80% confidence interval of their forecast and assessed the validity and potential impact on fertility of 46 factors. We also compare expert-derived projections of the TFR trends with the forecasts formulated by the UN World Population Prospects in 2010. The survey results in combination with the feedback provided by the invited experts then serve as a basis for formulating a set of projection scenarios for all low fertility countries up until 2050, which are additionally expanded (in a simpler form) through 2200. We present these scenarios and discuss past changes in fertility differences by level of education and their potential future trends in main regions. Presented analyses and projections indicate that a global convergence of fertility to around replacement level, envisioned in the UN projections, appears unlikely. Continuing differentiation combined with partial convergence in fertility towards lower levels is suggested as a more plausible scenario, with East Asia (including China) as well as Russia expected to have sustained very low fertility below 1.5 through 2050.

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Section: Fertility Postponement and Assisted Reproductionmentioning

confidence: 99%

Future Fertility in Low Fertility Countries

Basten

Sobotka

Zeman

et al. 2014

World Population and Human Capital in the Twenty-First Century

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“…This phenomenon is due to a combination of factors, but in general, subfertility in older women is primarily related to: poor quality of aging oocytes, reflecting chromosomal, morphological, and functional abnormalities (Beemsterboer et al 2006, Hunt & Hassold 2008, Broekmans et al 2009, Perheentupa & Huhtaniemi 2009; decreased ovarian reserve, marked by fewer oocytes (Richardson et al 1987, Ames et al 1995, Broekmans et al 2009, Perheentupa & Huhtaniemi 2009; and an altered hormonal environment resulting in ovulatory dysfunction (Broekmans et al 2009). Only about 5% of women with diminished ovarian reserve presently achieve pregnancy, despite use of ovulation inducing agents (Gougeon 2005, Braveman 2006, Habbema et al 2009). In the last 30 years a worldwide trend by women to delay childbearing until onset of the decline in fecundity (late 30s and 40s) has increased the risk of infertility (Ottolenghi et al 2004).…”

Section: Maternal Age and Fertilitymentioning

confidence: 99%

“…In the last 30 years a worldwide trend by women to delay childbearing until onset of the decline in fecundity (late 30s and 40s) has increased the risk of infertility (Ottolenghi et al 2004). Assisted reproductive technologies (ART) have compensated for the decreased natural fertility, but only to a limited extent (Braveman 2006, Habbema et al 2009, leaving many couples childless despite prolonged and demanding therapies for infertility.…”

Section: Maternal Age and Fertilitymentioning

confidence: 99%

“…Since age is highly negatively correlated with oocyte quality, advance maternal age is the most prominent impediment to a successful assisted reproductive program (Janny & Menezo 1996, Hunt & Hassold 2008, Habbema et al 2009. The evidence for impact of age is apparent in the increased percentages of embryo fragmentation during early cleavage stages in embryos from older women (Jurisicova et al 2006), and by an elevated cell death index in blastocysts from aged mice (Keefe et al 1995.…”

Section: Maternal Age and Fertilitymentioning

confidence: 99%

See 1 more Smart Citation

Ceramide and mitochondrial function in aging oocytes: joggling a new hypothesis and old players

Kujjo¹,

Perez²

2012

Reproduction

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Maternal aging adversely affects oocyte quality (function and developmental potential) and consequently lowers pregnancy rates while increasing spontaneous abortions. Substantial evidence, especially from egg donation studies, implicates the decreased quality of an aging oocyte as a major factor in the etiology of female infertility. Nevertheless, the cellular and molecular mechanisms responsible for the decreased oocyte quality with advanced maternal aging are not fully characterized. Herein we present information in the published literature and our own data to support the hypothesis that during aging induced decreases in mitochondrial ceramide levels and associated alterations in mitochondrial structure and function are prominent elements contributing to reduced oocyte quality. Hence, by examining the molecular determinants that underlie impairments in oocyte mitochondria, we expect to sieve to a better understanding of the mechanistic anatomy of oocyte aging.Reproduction (2012) 143 1-10

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“…34 However, many couples with unexplained, mild or moderate subfertility may resort to ART sooner than necessary because they still have reasonable chances of having a natural pregnancy. 37 Moreover, a minority of couples with severe reproductive disorders still conceive spontaneously after unsuccessful ART. 38 In addition, the widespread concerns about conceiving twins and triplets after ART, and the increasing success rate of single embryo transfer, already have led or soon will lead to a reduction in multiple deliveries.…”

Section: Reproduction Fecundity and Fertility: What Is Their Relatiomentioning

confidence: 99%