The Effect of in Vivo Occlusion on Human Stratum Corneum Hydration-Dehydration in Vitro

On the Variation of Water Diffusion Coefficient in Stratum Corneum With Water Content

“…Anderson et al 9 and that on porcine SC obtained by Rauma et al 6 These data were not easily reconciled with the results shown in Fig. 5; the former gave much lower values of D, the latter much higher values.…”

“…<Insert Table 2> Dynamic water sorption analysis Several researchers 3,5,6,9 have studied the dynamics of SC water sorption and/or desorption by recording the skin weight change over time while exposing it to water vapor. In this paper, the data of El-Shimi and Princen 3 and Liron et al 5 are analyzed in detail.…”

“…Water diffusion in the skin's outermost layer, the stratum corneum (SC), has been studied for many years due to its importance in the conservation of body fluids and in skin health. [1][2][3][4][5][6][7][8][9][10][11][12] A frequently studied special case is steady-state diffusion across fully hydrated skin, as summarized by Johnson et al 13 Related studies have examined the distribution of water in the skin under a variety of conditions. 3,12,[14][15][16][17][18][19] It is clear from this work that high levels of skin hydration are associated with a high water diffusion coefficient, as well as those of other permeants, 20 in the SC.…”

Thermodynamics of Water Interaction with Human Stratum Corneum I: Measurement by Isothermal Calorimetry

“…According to the chosen analysis (Fig. 3) heat evolution associated with water vapor sorption onto SC occurred predominately in the first 2 h following exposure and was essentially complete after 4 h. The measurements do not preclude a gradual release of heat extending over a much longer period; in fact, such a release is possible as SC continues to swell for days following exposure to high humidities3,40 or liquid water 1,41. However, the amounts of water found in the tissue at the conclusion of each exposure were smaller than those found in more extended studies of SC water sorption, especially at high values of RH (Fig.…”

Equilibrium Water Sorption in Human Stratum Corneum

“…The water handling properties of stratum corneum (SC) are key to both the barrier function and condition of the skin. Accounts of water sorption1–8 and diffusion5,8–12 in the SC have been published periodically, with various interpretations. Investigators agree on the general shape of the equilibrium water sorption isotherm for the SC; it can be described by a Type II or Type III isotherm, with a small amount of water persisting to very low relative humidity and a large increase at high relative humidity that is associated with pronounced swelling of the tissue 1–8.…”