The effect of indirect trauma on the rat temporomandibular joint

Luz, João Gualberto de Cerqueira; Jaeger, Ruy Gastaldoni; Araújo, Vera Cavalcanti de; Rezende, J R de

doi:10.1016/s0901-5027(05)80697-6

Cited by 40 publications

(35 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, such alterations occurred in only one specimen of each group of substance, which suggests a need for further studies. Similar findings, albeit more thorough, have been reported after indirect trauma in the rat TMJ 10 . No similar findings with carrageenan or formalin have been reported in the related literature, probably due to the short periods of observation.…”

supporting

confidence: 88%

Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint

Goulart¹,

Correia²,

Sousa

et al. 2005

Braz. oral res.

View full text Add to dashboard Cite

ABSTRACT:The aim of this study was to evaluate the effects of the injection of two phlogistic agents, carrageenan and formalin, in the rat TMJ, and the inflammatory process induced by these substances. In this study, a total of 45 adult rats were distributed in two experimental groups and a control group. The animals were sacrificed after three hours, 24 hours, three days, seven days, and 15 days after a single injection of each substance. Histological data initially demonstrated an inflammatory process represented by acute infiltration, which later became mixed, and finally chronic in both experimental groups. Hyperplasia of the synovial membrane was observed after three days, being intense at seven days, and present after 15 days only in the formalin group. Local saline injection in the control group caused no inflammatory reaction. It was concluded that a single local injection of carrageenan or formalin was enough to induce inflammatory reaction in the TMJ and periarticular soft tissues, and that the resulting processes were similar, but more persistent in the formalin group. DESCRIPTORS: Temporomandibular joint; Inflammation; Carrageenan, adverse effects; Formalin, adverse effects. RESUMO:O objetivo deste trabalho foi avaliar os efeitos da injeção de dois agentes flogísticos, ou seja, carragenina ou formalina, na ATM do rato, e a evolução do quadro inflamatório provocado por essas substâncias. Foram utilizados 45 ratos, divididos em dois grupos experimentais e um grupo controle. Os animais foram sacrificados em lotes de três de cada grupo após três horas, 24 horas, três dias, sete dias e 15 dias da injeção. Histologicamente a reação inflamatória em ambos os grupos experimentais iniciou-se com infiltrado inflamatório agudo, tornando-se misto e depois crônico. Sinais de hiperplasia da membrana sinovial foram observados aos três dias, intensos aos sete dias, estando presentes aos 15 dias somente no grupo da formalina. A injeção de solução salina (grupo controle) não provocou reação inflamatória. No presente trabalho foi concluído que uma injeção local única na região da ATM de carragenina ou de formalina foi suficiente para induzir reação inflamatória na articulação e nos tecidos moles periarticulares. As reações inflamatórias resultantes da injeção desses agentes flogísticos foram semelhantes, mas o grupo da formalina mostrou infiltrado inflamatório mais persistente.

show abstract

supporting

confidence: 88%

Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint

Goulart¹,

Correia²,

Sousa

et al. 2005

Braz. oral res.

View full text Add to dashboard Cite

show abstract

“…On the other hand, the undernourished fracture group presented a progressive filling of the articular space with connective fibrous tissue, with areas of adherence of the disc to the condyle, as well as signs of resorption of the articular surface of the condyle. Adherence of the condyle to the temporal fossa was demonstrated in a study with indirect trauma to the temporomandibular joint associated to rupture of the disc (Luz et al, 1991), and deformation of the condyle was associated to major dislocations of experimental condyle fractures (Takatsuka et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophylic and serofibrinous exudation around the fracture site occurs as part of the inflammatory process related to fractures (Craft et al, 1974;Teixeira et al, 1998). Neutrophylic exudation along the articular capsule and adjacent muscle fibres, as well as fibrinousehaemorrhagic exudation into the articular space, is part of the inflammatory process associated with joint injury (Luz et al, 1991;Luz and Araújo, 2001). An experimental study demonstrated that the isolated induction of haemarthrosis in the temporomandibular joint raised neither signs of intra-articular damage nor inflammation (Alons et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Healing of displaced condylar process fracture in rats submitted to protein undernutrition

Rodrigues

Corrêa

Luz

2011

Journal of Cranio-Maxillofacial Surgery

View full text Add to dashboard Cite

“…[42] Compressive forces on the TMJ have been shown to cause local changes in articular cartilage and in the condyle. [43] Damage to the TMJ alters its physical properties and further affects its ability to withstand compressive and shearing forces. The risks and the degree of severe degenerative changes in the TMJ after orthognathic surgical interventions in the mandible have been documented.…”

Section: Discussionmentioning

confidence: 99%

Morphologic and clinical changes in the temporomandibular joint following orthognathic surgery

Louis¹,

Kotrashetti²,

Roy³

et al. 2015

JCRI

View full text Add to dashboard Cite

The effect of indirect trauma on the rat temporomandibular joint

Cited by 40 publications

References 23 publications

Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint

Study of the inflammatory process induced by injection of carrageenan or formalin in the rat temporomandibular joint

Healing of displaced condylar process fracture in rats submitted to protein undernutrition

Morphologic and clinical changes in the temporomandibular joint following orthognathic surgery

Contact Info

Product

Resources

About