The Effect of Individualised Glycemic Intervention on Wound Healing Rate in Diabetic Foot Ulcer (The EIGIFU Study)

Lim, Kim Piow; Nasruddin, Azraai; Rani, Noraishah Md

doi:10.15605/jafes.033.01.04

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…For the past 10 years in Malaysia, there has been an increase in diabetic cases, mainly affecting individuals of 30 years or older [14] in which 15% of the diabetic patients developed DFU [15]. Meanwhile, a statistic showed that 17% of patients admitted to the General Hospital of Kuala Lumpur are mainly due to DFU [16].…”

Section: Introductionmentioning

confidence: 99%

The Insights of Microbes’ Roles in Wound Healing: A Comprehensive Review

2021

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A diverse range of normal flora populates the human skin and numbers are relatively different between individuals and parts of the skin. Humans and normal flora have formed a symbiotic relationship over a period of time. With numerous disease processes, the interaction between the host and normal flora can be interrupted. Unlike normal wound healing, which is complex and crucial to sustaining the skin’s physical barrier, chronic wounds, especially in diabetes, are wounds that fail to heal in a timely manner. The conditions become favorable for microbes to colonize and establish infections within the skin. These include secretions of various kinds of molecules, substances or even trigger the immune system to attack other cells required for wound healing. Additionally, the healing process can be slowed down by prolonging the inflammatory phase and delaying the wound repair process, which causes further destruction to the tissue. Antibiotics and wound dressings become the targeted therapy to treat chronic wounds. Though healing rates are improved, prolonged usage of these treatments could become ineffective or microbes may become resistant to the treatments. Considering all these factors, more studies are needed to comprehensively elucidate the role of human skin normal flora at the cellular and molecular level in a chronic injury. This article will review wound healing physiology and discuss the role of normal flora in the skin and chronic wounds.

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Section: Introductionmentioning

confidence: 99%

The Insights of Microbes’ Roles in Wound Healing: A Comprehensive Review

2021

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Presentation and Outcome of Infection in Hospitalized Patients with Diabetic Foot at a Tertiary Care Hospital

Miyan,

Waris,

Zafar

et al. 2024

JODB

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Background and Aim: To observe presentation and outcome of diabetic foot infection (DFI) in hospitalized patients at a tertiary care center. Materials and Methods: This prospective clinical study included all those patients who visited the out-patient department (OPD) of the foot clinic of Baqai Institute of Diabetology and Endocrinology and were admitted to the hospital due to DFI from August 2020 to April 2021. Patients with DFI were assessed and classified into mild, moderate, and severe infections according to the Infectious Disease Society of America (IDSA)/International Working Group On Diabetic Foot guideline protocol. Primary outcome was healing either without amputation, or with minor or major amputation. Results: A total of 2405 patients visited the OPD and 658 got admitted. Of these 211 patients with DFI were included. Males 158 (75%) were predominant. As per IDSA classification, 99 (46.9%) had severe infection, 94 (44.5%) had moderate, while 18 (8.53%) had mild infection. Overall, 150 (71.1%) infected Diabetic Foot Ulcers (DFUs), 67 (44.6%) and 65 (43.3%) DFUs with moderate infection and severe infection respectively were healed without any amputation. Conclusion: Infection was found to be the major cause of amputation in most patients with toe amputation being more common. Early referral of patients to the tertiary care unit and a multidisciplinary approach may help prevent DFI from major and minor amputations.

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The Effect of Individualised Glycemic Intervention on Wound Healing Rate in Diabetic Foot Ulcer (The EIGIFU Study)

Cited by 2 publications

References 17 publications

The Insights of Microbes’ Roles in Wound Healing: A Comprehensive Review

The Insights of Microbes’ Roles in Wound Healing: A Comprehensive Review

Presentation and Outcome of Infection in Hospitalized Patients with Diabetic Foot at a Tertiary Care Hospital

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