The Effect of Indomethacin Upon Experimental Fractures in the Rat

Indomethacin and celecoxib improve tendon healing in rats

“…This view is supported by an increase in the percentage of insoluble collagen and the collagen content in rat-tail tendons after treatment with indomethacin (Vogel 1977). In vivo, bone fractures in rats treated with indomethacin show increases in hydroxyproline incorporation and fibrogenesis, respectively (Ro et al 1978, Elves et al 1982. Therefore, the impairment in fracture repair may be due to changes in cell differentiation pathways, rather than a general inhibition of matrix production.…”

Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion

“…28 This group of drugs has been found to inhibit prostaglandin-mediated bone remodelling in vitro and in animal models in a dose-dependent fashion. 19 Numerous reports have shown their interference with the healing of bone in both experimental and human fractures, 13,[15][16][17][18]22,23,25 which may be due to inhibition of cyclo-oxygenase 2 activity, 29 and this may also be expected to occur with the newest anti-inflammatory drugs, the COX2 inhibitors.…”

“…In addition, in multiple animal models and clinical studies, indomethacin and other non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to impair healing of fractures with reduced callus and altered remodelling of the Haversian systems. [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] Our aim was to determine if indomethacin, when used for prophylaxis for HO after surgery for acetabular fracture, increases the risk of nonunion in patients with associated fracture of a long bone.…”

Cyclooxygenase-2 Inhibitor Inhibits the Fracture Healing.

“…Traditional NSAIDS have been reported to delay fracture healing (Altman et al, 1995;Elves et al, 1982). However, the effects of the specific cox-2 inhibitor on fracture healing are still unclear.…”