The Effect of Infliximab, a Monoclonal Antibody Against TNF-α, on Disc Herniation Resorption

Autio, Reijo; Karppinen, Jaro; Niinimäki, Jaakko; Ojala, Risto; Veeger, Nic; Korhonen, Timo; Hurri, Heikki; Tervonen, Osmo

doi:10.1097/01.brs.0000244616.64962.9e

Cited by 31 publications

(39 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33 This reduction in size is most often caused by a herniated disc or a degenerative lesion of the zygapophyseal joints. 3,6,9 Typical symptoms of CR include neck, periscap-T T STUDY DESIGN: Participant-and assessorblinded randomized clinical trial.…”

Section: Ervical Radiculopathy (Cr)mentioning

confidence: 99%

Comparison of 2 Manual Therapy and Exercise Protocols for Cervical Radiculopathy: A Randomized Clinical Trial Evaluating Short-Term Effects

Langevin¹,

Desmeules²,

Lamothe³

et al. 2015

J Orthop Sports Phys Ther

View full text Add to dashboard Cite

Section: Ervical Radiculopathy (Cr)mentioning

confidence: 99%

Comparison of 2 Manual Therapy and Exercise Protocols for Cervical Radiculopathy: A Randomized Clinical Trial Evaluating Short-Term Effects

Langevin¹,

Desmeules²,

Lamothe³

et al. 2015

J Orthop Sports Phys Ther

View full text Add to dashboard Cite

“…The lack of such knowledge helps explain why the clinical use of anti-TNFα therapies have had limited success at addressing radicular pain 1,2,18,19 . Multiple studies demonstrated that pro-inflammatory cytokines can induce a positive feedback loop, where the expression of one cytokine drives more expression of that cytokine and others, perpetuating the inflammatory environment 20,21 .…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells

Walter

Purmessur

Likhitpanichkul

et al. 2015

Spine

View full text Add to dashboard Cite

Study Design Human nucleus pulposus (NP) cell culture study investigating response to tumor necrosis factor-α (TNFα), effectiveness of clinically available anti-inflammatory drugs, and interactions between pro-inflammatory cytokines. Objective To characterize the kinetic response of pro-inflammatory cytokines released by human NP cells to TNFα stimulation and the effectiveness of multiple anti-inflammatories with 3 sub-studies: Timecourse, Same-time blocking, Delayed blocking. Summary of Background Data Chronic inflammation is a key component of painful intervertebral disc (IVD) degeneration. Improved efficacy of anti-inflammatories requires better understanding of how quickly NP cells produce pro-inflammatory cytokines and which pro-inflammatory mediators are most therapeutically advantageous to target. Methods Degenerated human NP cells (n=10) were cultured in alginate with or without TNFα (10ng/mL). Cells were incubated with one of four anti-inflammatories (anti-IL-6 receptor/atlizumab, IL-1 receptor anatagonist, anti-TNFα/infliximab and sodium pentosan polysulfate/PPS) in two blocking-studies designed to determine how intervention timing influences drug efficacy. Cell viability, protein and gene expression for IL-1β, IL-6 & IL-8 were assessed. Results Timecourse: TNFα substantially increased the amount of IL-6, IL-8 & IL-1β, with IL-1β and IL-8 reaching equilibrium within ~72 hours (IL-1β: 111±40pg/mL, IL-8: 8478±957pg/mL), and IL-6 not reaching steady state after 144 hours (1570±435 pg/mL). Anti-TNFα treatment was most effective at reducing the expression of all cytokines measured when added at the same time as TNFα stimulation. Similar trends were observed when drugs were added 72 hours after TNFα stimulation, however, no anti-inflammatories significantly reduced cytokine levels compared to TNF control. Conclusion IL-1β, IL-6 and IL-8 were expressed at different rates and magnitudes suggesting different roles for these cytokines in disease. Autocrine signaling of IL-6 or IL-1β did not contribute to the expression of any pro-inflammatory cytokines measured in this study. Anti-inflammatory treatments were most effective when applied early in the inflammatory process, when targeting the source of the inflammation.

show abstract

“…Energy density 2 J/cm2 at each point, Treatment time 120 seconds at each point, Daily energy delivered 12 J, Total energy delivered 180 J. Application mode Probe held stationary in contact with skin, Anatomical site Local transforaminal (2.5 cm and 3.5 cm laterally from spinous process of involved (C6, C7) and the two next distal segments) [28,29]. Data Analysis: The Statistical Package of Social Sciences (SPSS) for windows version 19.0 was used to analyze the data.…”

Section: A Abdallah Rabab a Mohamed Et Al Effect Of Snags Mulligamentioning

confidence: 99%

Effect of Snags Mulligan Technique Versus Low Level Laser Therapy on Patients With Unilateral Cervical Radiculopathy

Abdallah¹,

Mohamed²,

Sharaf³

2017

IJPR

View full text Add to dashboard Cite

Background: Cervical radiculopathy is a condition caused by the compression of the nerve root in cervical spine that commonly manifests as neck pain and it may also radiate from the neck into the distribution of the affected nerve root. There is a significant amount of evidence available to support the benefit of physical therapy and manual techniques in general for patients with neck pain with or without radicular symptoms.Objective: This study was conducted to assess the efficacy of Mulligan mobilization and low level laser therapy (LLLT) on pain intensity level, EMG dermatomal somatosensory evoked potential and functional level in patients with unilateral cervical radiculopathy. Materials and Methods:Fifty patients of both genders with diagnosis of unilateral cervical radiculopathy, their ages ranged from 40 to 55. They were randomly assigned into two groups; Group A: Patients received SNAGs Mulligan technique, in addition to conventional program. Group B: Patients received LLLT, in addition to conventional program. The treatment was conducted at a frequency of three sessions per week for four weeks.Results: Patients in both groups showed significant improvement post treatment in all the measured variables ; there was non-significant difference between two groups post-study in pain level where P-value was (0.128). There were no significant differences between two groups in amplitude, distal latency post-study, where P-values were (0.132) and (0.328) respectively. There were no significant differences between two groups in functional ability, where P-value was (0.156).Conclusion: Study concludes that both LLLT and SNAGs Mulligan techniques have shown positive results and are effective in improvements in pain intensity, EMG dermatomal somatosensory evoked potential and functional level among Patients with unilateral cervical radiculopathy.

show abstract

The Effect of Infliximab, a Monoclonal Antibody Against TNF-α, on Disc Herniation Resorption

Abstract: Infliximab did not appear to interfere with disc herniation resorption over a 6-month period.

Cited by 31 publications

References 16 publications

Comparison of 2 Manual Therapy and Exercise Protocols for Cervical Radiculopathy: A Randomized Clinical Trial Evaluating Short-Term Effects

Comparison of 2 Manual Therapy and Exercise Protocols for Cervical Radiculopathy: A Randomized Clinical Trial Evaluating Short-Term Effects

Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells

Effect of Snags Mulligan Technique Versus Low Level Laser Therapy on Patients With Unilateral Cervical Radiculopathy

Contact Info

Product

Resources

About