The effect of insulin-dependent diabetes mellitus on basal and distention-induced acid and pepsin secretion in rat

Acid secretory response and electrolyte composition of gastric juice in Diabetic rats

“…Perusicova (2004) reported that the impaired function of the gastrointestinal tract related to diabetes mellitus results from diabetic autonomic neuropathy, impaired sensory innervation and a direct effect of chronic hyperglycemia. A reduction in histamine stimulated acid output was observed in the diabetic group and this is consistent with the work of Ozcelikay et al (1993) who reported decrease in histamine induced acid secretion in the diabetic rat. This is also corroborated by Mehta et al (1993) who reported severe impairment in the secretory response of parietal cells in diabetes mellitus.…”

“…Carbachol stimulated acid output was also observed to be reduced in the diabetic group when compared with the control group. Tashima et al (2000) however reported results which are contrary to the results obtained in this study and to those of Ozcelikay et al (1993) and Mehta et al (1993). He observed no response to histamine stimulation while the response to carbachol was enhanced in streptozotocin diabetic rats.…”

“…The response of parietal cells to histamine has been reported to be impaired in diabetes mellitus (Mehta et al, 1993) whereas Tashima et al (2000) reported that the acid secretory response to histamine was unchanged in diabetes mellitus. In addition the histamine stimulated acid secretory output has also been reported to be reduced (Ozcelikay et al, 1993) in diabetes mellitus. Nabavizadeh et al (2004) also reported that though diabetes affects gastric secretion its exact effect has not been fully understood.…”

“…In addition the histamine stimulated acid secretory output has also been reported to be reduced (Ozcelikay et al, 1993) in diabetes mellitus. Nabavizadeh et al (2004) also reported that though diabetes affects gastric secretion its exact effect has not been fully understood.…”

“…Though histamine stimulation of acid secretion in diabetes has been reported (Mehta et al, 1993;Ozcelikay et al, 1993;Tashima et al 2000). There is a dearth of information on the effect of carbachol stimulation of acid secretion in alloxan induced diabetes mellitus and the effect of diabetes on the electrolyte composition of gastric juice in rats.…”