The ability of the human auditory system to function under unfavorable acoustic conditions, for example focusing on a single talker in a multi-talker environment with background noise and reverberation, is well known (e.g., Cherry, 1953;Kaiser and David, 1960). The theory of auditory scene analysis (ASA, Bregman, 1994) states that the auditory system actively and passively groups several signal features into internal representations of sound sources. This separation helps in tasks like understanding speech in noise or tracking the movement of a sound source. Two of the important signal features are binaural cues derived from a joint processing of the signals received at both ears and pitch or harmonicity, as, e.g., generated by voiced speech sounds (Darwin and Carlyon, 1995). Binaural cues give information about the location and movement of a sound source, while harmonicity processing enables grouping of signal energy according to a fundamental frequency (F0), which helps for example in the separation of different voices. As the signals of interest in auditory scene analysis (voiced speech, animal calls, music) are often periodical (e.g., Fletcher, 1992), the aim of this thesis is to provide psychophysical data and develop and evaluate models for binaural and harmonic processing of periodic signals.The first part of this thesis deals with the processing of interaural time differences (ITDs) in signals with a periodic envelope. Here, a custom periodic envelope is constructed consisting of several segments. The influence of each envelope segment on the sensitivity to ITDs is measured in psychophysical experiments. The ability of an established model for ITD sensitivity (Bernstein and Trahiotis, 2002) to predict the data is evaluated and the model is extended by principles of neuronal adaptation to improve model performance. This is of particular interest as it offers valuable hints on the binaural processing of voiced speech sounds at high frequencies and possible coding strategies for binaural hearing aids or cochlear implants.The second and third part deal with combined processing of harmonicity and ITDs. The second part establishes the method of measuring detection thresholds in harmonicity research. In psychophysical experiments, the ability of subjects to detect a single target component embedded in a tone complex is tested, while the target tone is in harmonic or mis-3 tuned relationship to the masking tone complex. Based on this method, the third part of this thesis reports on combination experiments, where the target tone is additionally presented with an interaural phase difference (IPD). An auditory computer model based on amplitude modulation processing and equalization-cancellation (Durlach, 1963) is used to predict the psychophysical results. Various hypotheses on the combination of binaural and harmonicity information are tested against the human and model data. The results of both studies shed light on the combined processing of two important signal features in ASA and are of high relevanc...