The effect of interfacial bonding of calcium phosphate cements containing bio-mineralized multi-walled carbon nanotube and bovine serum albumin on the mechanical properties of calcium phosphate cements

Low, Kah Ling; Zein, Sharif Hussein Sharif; Tan, Soon Huat; McPhail, David S.; Boccaccını, Aldo R.

doi:10.1016/j.ceramint.2011.05.092

Cited by 17 publications

(4 citation statements)

References 51 publications

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“…The compressive strength and Young’s modulus of PVA-reinforced cements were higher than some other fiber-reinforced calcium phosphate cements (e.g., collagen reinforced apatite cement [34] and similar to some others (e.g., carbon nano tube/reinforced apatite cements [35]) [6,7]. The DTS and the work of fracture calculated from the DTS were not reported in most studies on fiber reinforcement, since bending tests (three or four point bending) were commonly reported instead [7].…”

Section: Discussionmentioning

confidence: 95%

The Addition of Poly(Vinyl Alcohol) Fibers to Apatitic Calcium Phosphate Cement Can Improve Its Toughness

et al. 2019

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Calcium phosphate cements, and in particular hydroxyapatite cements, have been widely investigated for use as bone void fillers due to their chemical similarity to bone and related osteoconductivity. However, they are brittle, which limits their use to non-load-bearing applications. The aim of the current study was to improve the toughness of hydroxyapatite cements through fiber reinforcement. The effect of the addition of hydrophilic, poly(vinyl-alcohol) (PVA) fibers to hydroxyapatite cement was evaluated in terms of mechanical properties, including compressive strength, diametral tensile strength and toughness (work of fracture), as well as setting time, phase composition and cement morphology. The fiber reinforcement enhanced the fracture resistance of the hydroxyapatite cement, but also simultaneously reduced the compressive strength and setting time of the cements. However, cement with 5 wt % of fibers (of the powder component) could be considered a good compromise, with a compressive strength of 46.5 ± 4.6 MPa (compared to 62.3 ± 12.8 MPa of that without fibers), i.e., still much greater than that of human trabecular bone (0.1–14 MPa). A significantly higher diametral tensile strength (9.2 ± 0.4 MPa) was found for this cement compared to that without fibers (7.4 ± 1.5 MPa). The work of fracture increased four times to 9.1 ± 1.5 kJ/m2 in comparison to the pristine apatite. In summary, the hydroxyapatite cements could be reinforced by suitable amounts of PVA fibers, which resulted in enhancing the material’s structural integrity and ductility, and increased the material’s resistance to cracking.

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Section: Discussionmentioning

confidence: 95%

The Addition of Poly(Vinyl Alcohol) Fibers to Apatitic Calcium Phosphate Cement Can Improve Its Toughness

et al. 2019

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“… 160 Another study by Low et al demonstrated the strong interfacial bonding effect when bio-mineralized hydroxyl functionalized multi-walled carbon nanotubes were added onto calcium phosphate cement, which could be beneficial for fabricating electrodes for biosensing application with higher sensitivity and selectivity towards analytes of interest. 161 To detect ricin, a silica-coated magnetic nanoparticle-based silver enhancement immunoassay was developed. 162 Similarly, Tyagi et al proposed a method to detect urea, in which a thin film NiO nanoparticle was deposited onto an indium tin oxide (ITO)-coated glass substrate that showed higher affinity and catalytic activity with redox behavior due to the great properties of NiO-NPs.…”

Section: Applicationsmentioning

confidence: 99%

Potentialities of bioinspired metal and metal oxide nanoparticles in biomedical sciences

Singh¹,

et al. 2021

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“…[13][14][15][16][17] However, the weak interfacial adhesion between the organic and inorganic phases still remains a major concern, which limits further enhancement of CPCs. 18 Hence, a number of studies have attempted to modify these fillers to ameliorate interfacial bonding between the 2 phases. 19,20 Silk fibroin (SF), a popular material with good biocompatibility, is a promising biomaterial for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Reinforcement of calcium phosphate cement using alkaline-treated silk fibroin

Hu¹,

He²,

Han³

et al. 2018

IJN

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BackgroundBone cement plays an important role in the treatment of osteoporotic vertebral compression fractures. Calcium phosphate cement (CPC) is a potential alternative to poly(methyl methacrylate), currently the gold standard of bone cements. However, the poor mechanical properties of CPCs limit their clinical applications. The objective of this study was to develop reinforced CPCs for minimally invasive orthopedic surgeries by compositing silk fibroin (SF) with α-tricalcium phosphate.MethodsSF solution was treated with calcium hydroxide and characterized by Zeta potential analyzer and Fourier transform infrared spectroscopy. The alkaline-treated SF (tSF) was com-posited with α-tricalcium phosphate to obtain tSF/CPC composite, which was characterized using mechanical tests, scanning electron microscopy, handling property and biocompatibility tests, and sheep vertebral augmentation tests.ResultsUpon treatment with calcium hydroxide, larger SF particles and more abundant negative charge appeared in tSF solution. The tSF/CPCs exhibited a compact structure, which consisted of numerous SF -CPC clusters and needle-like hydroxyapatite (HAp) crystals. In addition, high transition rate of HAp in tSF/CPCs was achieved. As a result, the mechanical property of tSF/ CPC composite cements was enhanced remarkably, with the compressive strength reaching as high as 56.3±1.1 MPa. Moreover, the tSF/CPC cements showed good injectability, anti-washout property, and decent biocompatibility. The tSF/CPCs could be used to augment defected sheep vertebrae to restore their mechanical strength.ConclusiontSF/CPC may be a promising composite bone cement for minimally invasive orthopedic surgeries.

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The effect of interfacial bonding of calcium phosphate cements containing bio-mineralized multi-walled carbon nanotube and bovine serum albumin on the mechanical properties of calcium phosphate cements

Cited by 17 publications

References 51 publications

The Addition of Poly(Vinyl Alcohol) Fibers to Apatitic Calcium Phosphate Cement Can Improve Its Toughness

The Addition of Poly(Vinyl Alcohol) Fibers to Apatitic Calcium Phosphate Cement Can Improve Its Toughness

Potentialities of bioinspired metal and metal oxide nanoparticles in biomedical sciences

Reinforcement of calcium phosphate cement using alkaline-treated silk fibroin

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