The effect of interleukin‐20 on periodontal tissue destruction in individuals with periodontitis

Objectives: To determine whether the serum matrix metalloproteinase-8 (MMP-8) level is elevated in periodontitis patients compared with that in periodontally healthy individuals, we conducted a meta-analysis to assess its diagnostic value. This study aims to provide insight into the increased prevalence and severity of systemic diseases in periodontitis patients, as well as the potential of serum MMP-8 in the rapid diagnosis of periodontitis. Methods: A comprehensive search following the PECO criteria of PubMed, Embase and the Cochrane Library from their inception to October 8, 2024, was conducted to retrieve comprehensive relevant articles. The complete selection procedure was meticulously documented with transparency and was registered in PROSPERO CRD42024608648. The methodological qualities of the included articles were evaluated following the Newcastle‒Ottawa Scale (NOS) grading system. The level of serum MMP-8 was converted to a standard (mean ± standard deviation (SD)), and meta-analysis was conducted with Review Manager 5.4 software. Sensitivity analyses were performed with Stata 17.0 software. Results: A total of 12 studies, including 10 case‒control studies and 2 cohort studies, were ultimately included, with a total of 871 participants. The results of the meta-analysis revealed higher serum MMP-8 levels in periodontitis patients than in healthy controls (SMD 0.64, 95% CI 0.27 to 1.01; 12 studies, 871 participants). High heterogeneity (I2 = 86%) indicated variability in outcomes, possibly influenced by regional factors. Duval and Tweedie’s trim and fill procedure was conducted, and no evidence of a small study effect was found. Sensitivity analyses revealed great stability of the data included. Conclusions: Our meta-analysis revealed that the serum MMP-8 level in periodontitis patients was likely greater than that in healthy subjects, but further studies on regional factors are needed to clarify this conclusion considering the degree of heterogeneity.

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Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets

Neurath,

Kesting

2024

Front. Immunol.

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Chronic inflammatory processes in the oral mucosa and periodontitis are common disorders caused by microflora and microbial biofilms. These factors activate both the innate and adaptive immune systems, leading to the production of pro-inflammatory cytokines. Cytokines are known to play a crucial role in the pathogenesis of gingivitis and periodontitis and have been proposed as biomarkers for diagnosis and follow-up of these diseases. They can activate immune and stromal cells, leading to local inflammation and tissue damage. This damage can include destruction of the periodontal ligaments, gingiva, and alveolar bone. Studies have reported increased local levels of pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta), tumor necrosis factor (TNF), IL-6, IL-17, and IL-23, in patients with periodontitis. In experimental models of periodontitis, TNF and the IL-23/IL-17 axis play a pivotal role in disease pathogenesis. Inactivation of these pro-inflammatory pathways through neutralizing antibodies, genetic engineering or IL-10 function has been demonstrated to reduce disease activity. This review discusses the role of cytokines in gingivitis and periodontitis, with particular emphasis on their role in mediating inflammation and tissue destruction. It also explores new therapeutic interventions that offer potential for research and clinical therapy in these chronic inflammatory diseases.

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The effect of interleukin‐20 on periodontal tissue destruction in individuals with periodontitis

Cited by 3 publications

References 55 publications

The role of interleukin-20 on inflammatory stress and periodontal tissue destruction in patients with metabolic syndrome and periodontitis

The role of interleukin-20 on inflammatory stress and periodontal tissue destruction in patients with metabolic syndrome and periodontitis

Relationship between Serum Matrix Metalloproteinase-8 and Periodontitis: A PRISMA-Compliant Systematic Review and Meta-Analysis

Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets

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