The effect of intermittent hypoxia on obstructive sleep apnea: beneficial or detrimental?

Chamberlin, Nancy L.; Ling, Liming

doi:10.1152/japplphysiol.01191.2010

Cited by 7 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it should be noted that some beneficial effects of intermittent hypoxia have been evidenced in both animal models and OSA with regard to long-term facilitation and hypoxic ventilatory response [20,21]. Exposure to acute intermittent hypoxia or repeated carotid sinus nerve stimulation causes a persistent increase in respiratory activity [20]; whether this is beneficial in OSA remains unknown.…”

Section: Basic Mechanisms Linking Osa and Cardiovascular Diseasesmentioning

confidence: 99%

“…Exposure to acute intermittent hypoxia or repeated carotid sinus nerve stimulation causes a persistent increase in respiratory activity [20]; whether this is beneficial in OSA remains unknown. It has been suggested that alteration in long-term facilitation and hypoxic ventilatory response in reply to intermittent hypoxia exposure could lead to breathing stability and reduction in apnoea/hypopnoea index, although this is still conflicting [22].…”

Section: Basic Mechanisms Linking Osa and Cardiovascular Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Sleep apnoea and the heart

et al. 2013

View full text Add to dashboard Cite

Sleep apnoea is associated with significant daytime functioning impairment and marked cardiovascular morbidities, leading to a significant increase in mortality. Sympathetic activation, oxidative stress and systemic inflammation have been shown to be the main intermediary mechanisms associated with sleep apnoea and intermittent hypoxia. There are now convincing data regarding the association between hypertension, arrhythmias, coronary heart disease, heart failure, increased cardiovascular mortality and sleep apnoea. This has been evidenced in sleep apnoea patients and is supported by experimental data obtained in intermittent hypoxia. Whether treating sleep apnoea enables chronic cardiovascular consequences to be reversed is not fully established as regard coronary heart disease, arrhythmias and heart failure. In this late condition, complex bidirectional relationships occur, with obstructive sleep apnoea being a risk factor for heart failure whilst central sleep apnoea mainly appears as a consequence of heart failure. It remains to be established in adequately designed studies, i.e. large randomised controlled trials, whether treating sleep apnoea can improve heart failure morbidity and mortality. @ERSpublications Sleep apnoea is associated with arrhythmias, coronary disease and heart failure through intermittent hypoxia http://ow.ly/ne19T

show abstract

Section: Basic Mechanisms Linking Osa and Cardiovascular Diseasesmentioning

confidence: 99%

Section: Basic Mechanisms Linking Osa and Cardiovascular Diseasesmentioning

confidence: 99%

Sleep apnoea and the heart

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Even more, OSA has been related to an increased risk of cardiovascular and cerebrovascular diseases, such as systemic hypertension, atrial fibrillation, and cerebral stroke, 2 – 5 as well as to increased mortality 6 , 7 . The key factors involved are the repetitive intermittent hypoxia, the increased sympathetic activity, the sleep fragmentation, and the periodic cerebral hemodynamic changes but further understanding is desirable 8 , 9 …”

Section: Introductionmentioning

confidence: 99%

Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep

et al. 2018

View full text Add to dashboard Cite

Abstract.Obstructive apnea causes periodic changes in cerebral and systemic hemodynamics, which may contribute to the increased risk of cerebrovascular disease of patients with obstructive sleep apnea (OSA) syndrome. The improved understanding of the consequences of an apneic event on the brain perfusion may improve our knowledge of these consequences and then allow for the development of preventive strategies. Our aim was to characterize the typical microvascular, cortical cerebral blood flow (CBF) changes in an OSA population during an apneic event. Sixteen patients (age 58±8 years, 75% male) with a high risk of severe OSA were measured with a polysomnography device and with diffuse correlation spectroscopy (DCS) during one night of sleep with 1365 obstructive apneic events detected. All patients were later confirmed to suffer from severe OSA syndrome with a mean of 83±15 apneas and hypopneas per hour. DCS has been shown to be able to characterize the microvascular CBF response to each event with a sufficient contrast-to-noise ratio to reveal its dynamics. It has also revealed that an apnea causes a peak increase of microvascular CBF (30±17%) at the end of the event followed by a drop (−20±12%) similar to what was observed in macrovascular CBF velocity of the middle cerebral artery. This study paves the way for the utilization of DCS for further studies on these populations.

show abstract

“…However, these studies only focus on the macrocirculation level; on the microcirculation level, these parameters may have a different influence on microvascular CBF. Moreover, hypoxia has been found during apneic events, 70,71 which could also contribute to the local microvascular change.…”

Section: Discussionmentioning

confidence: 99%

Microvascular cerebral blood flow fluctuations in association with apneas and hypopneas in acute ischemic stroke

Gregori-Pla

2019

Neurophoton.

View full text Add to dashboard Cite

In a pilot study on acute ischemic stroke (AIS) patients, unexpected periodic fluctuations in microvascular cerebral blood flow (CBF) had been observed. Motivated by the relative lack of information about the impact of the emergence of breathing disorders in association with stroke on cerebral hemodynamics, we hypothesized that these fluctuations are due to apneic and hypopneic events. A total of 28 patients were screened within the first week after stroke with a pulse oximeter. Five (18%) showed fluctuations of arterial blood oxygen saturation (≥3%) and were included in the study. Near-infrared diffuse correlation spectroscopy (DCS) was utilized bilaterally to measure the frontal lobe CBF alongside respiratory polygraphy. Biphasic CBF fluctuations were observed with a bilateral increase of 27.1% AE 17.7% and 29.0% AE 17.4% for the ipsilesional and contralesional hemispheres, respectively, and a decrease of −19.3% AE 9.1% and −21.0% AE 8.9% for the ipsilesional and contralesional hemispheres, respectively. The polygraph revealed that, in general, the fluctuations were associated with apneic and hypopneic events. This study motivates us to investigate whether the impact of altered respiratory patterns on cerebral hemodynamics can be detrimental in AIS patients. © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

show abstract

The effect of intermittent hypoxia on obstructive sleep apnea: beneficial or detrimental?

Cited by 7 publications

References 16 publications

Sleep apnoea and the heart

Sleep apnoea and the heart

Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep

Microvascular cerebral blood flow fluctuations in association with apneas and hypopneas in acute ischemic stroke

Contact Info

Product

Resources

About