The effect of intermittent theta burst stimulation for cognitive dysfunction: a meta-analysis

Zheng, Beisi; Chen, Jianer; Cao, Manting; Zhang, Yujia; Chen, Shishi; Yu, Hong; Liang, Kang

doi:10.1080/02699052.2024.2344087

Cited by 2 publications

(1 citation statement)

References 68 publications

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“…Chu et al (2022) found that iTBS applied to patients with PSCI improved cognitive function and changed cortical activation in the dorsolateral prefrontal cortex (DLPFC), frontopolar cortex and Broca area. Two meta-analysis studies revealed that iTBS was a beneficial intervention for improving cognitive function in both healthy individual and patients with cognitive dysfunction (Pabst et al, 2022;Zheng et al, 2024). These studies indicated that iTBS showed a trend toward improvement of cognitive function.…”

Section: Introductionmentioning

confidence: 99%

Activation changes in patients with post-stroke cognitive impairment receiving intermittent theta burst stimulation: A functional near-infrared spectroscopy study

Yu,

Zheng,

Zhang

et al. 2024

NRE

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BACKGROUND: Intermittent theta burst stimulation (iTBS) has demonstrated efficacy in patients with cognitive impairment. However, activation patterns and mechanisms of iTBS for post-stroke cognitive impairment (PSCI) remain insufficiently understood. OBJECTIVE: To investigate the activation patterns and potential benefits of using iTBS in patients with PSCI. METHODS: A total of forty-four patients with PSCI were enrolled and divided into an iTBS group (iTBS and cognitive training) or a control group (cognitive training alone). Outcomes were assessed based on the activation in functional near-infrared spectroscopy (fNIRS), as well as Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) and the modified Barthel Index (MBI). RESULTS: Thirty-eight patients completed the interventions and assessments. Increased cortical activation was observed in the iTBS group after the interventions, including the right superior temporal gyrus (STG), left frontopolar cortex (FPC) and left orbitofrontal cortex (OFC). Both groups showed significant improvements in LOTCA and MBI after the interventions (p < 0.05). Furthermore, the iTBS group augmented superior improvement in the total score of MBI and LOTCA compared to the control group, especially in visuomotor organization and thinking operations (p < 0.05). CONCLUSION: iTBS altered activation patterns and improved cognitive function in patients with PSCI. The activation induced by iTBS may contribute to the improvement of cognitive function.

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Section: Introductionmentioning

confidence: 99%

Activation changes in patients with post-stroke cognitive impairment receiving intermittent theta burst stimulation: A functional near-infrared spectroscopy study

Yu,

Zheng,

Zhang

et al. 2024

NRE

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Time dependent changes in protein expression induced by intermittent theta burst stimulation in a cell line

Ismail,

Krishnan,

Jayaraj

et al. 2024

Front. Neurol.

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BackgroundIntermittent Theta Burst Stimulation (iTBS), a non-invasive brain stimulation technique, is recognized for its ability to modulate cortical neuronal activity. However, its effects over time and the dynamics following stimulation are less well understood. Understanding the temporal dynamics of iTBS effects is essential for optimizing the timing and frequency of stimulation in therapeutic applications.ObjectiveThis study investigated the temporal changes in protein expression induced by iTBS in Neuro-2a cells.MethodsWe analyzed protein expression in retinoic acid-differentiated Neuro-2a cells at multiple time points — 0.5, 3, 6, 12, and 24 hours post-iTBS — using Western blot and immunocytochemistry techniques.ResultsOur findings reveal a significant early increase in neurotransmitter receptor subunits, neurotrophic factors, and cytoskeletal proteins within the first 0.5 hour following iTBS. Notably, proteins such as mGLuR1, NMDAR1, GABBR2, and β-tubulin III showed substantial increase in expression. However, the effects of iTBS on protein expression was not sustained at later timepoints.ConclusionOur results suggest that iTBS can transiently alter the expression of specific proteins in Neuro-2a cells. Future research should investigate the potential benefits of repeated stimulations within the early time window to refine iTBS interventions, potentially expanding their research and clinical applications.

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The effect of intermittent theta burst stimulation for cognitive dysfunction: a meta-analysis

Cited by 2 publications

References 68 publications

Activation changes in patients with post-stroke cognitive impairment receiving intermittent theta burst stimulation: A functional near-infrared spectroscopy study

Activation changes in patients with post-stroke cognitive impairment receiving intermittent theta burst stimulation: A functional near-infrared spectroscopy study

Time dependent changes in protein expression induced by intermittent theta burst stimulation in a cell line

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