The effect of interparticulate friction and moisture on the crushing strength of sodium chloride compacts

Down, G.R.B.; McMullen, J.N.

doi:10.1016/0032-5910(85)80050-4

Cited by 35 publications

(4 citation statements)

References 10 publications

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“…solid bridges due to melting, self diffusion of atomes between surfaces and recrystallization of soluble materials in the compacts (62)(63)(64)(65). contact at an atomic level between adjacent surfaces in the compact.…”

Section: -Lo00mentioning

confidence: 99%

Bonding Surface area and Bonding Mechanism-Two Important Factors fir the Understanding of Powder Comparability

Nyström

Alderborn

Duberg

et al. 1993

Drug Development and Industrial Pharmacy

205

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Two factors could be regarded as primary factors for the compactability of powders: the dominating bond mechanism and the surface area over which these bonds are active. Owing to considerable experimental difficulties, these factors have not been evaluated in any detail for pharmaceutical materials. Instead, more indirect, secondary factors are normally studied and used for correlations with tablet strength. Such secondary factors particle size, shape and surface texture. Also the importance of volume reduction mechanisms, i.e. elastic deformation, plastic deformation and particle fragmentation have been studied in detail.For the investigation of dominating bond mechanisms and estimation of the magnitude of the surface area of the solids involved in interparticulate attraction in compacts several pharmaceutical excipients representing both plastically deforming materials (sodium chloride, Avicel@ PH 101, Sta-Rx 1500@, and sodium 2143

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Section: -Lo00mentioning

confidence: 99%

Bonding Surface area and Bonding Mechanism-Two Important Factors fir the Understanding of Powder Comparability

Nyström

Alderborn

Duberg

et al. 1993

Drug Development and Industrial Pharmacy

205

View full text Add to dashboard Cite

show abstract

“…This relationship is derived from microstructure formation and evolution predicted with the proposed particle mechanics approach and the generalized loading-unloading contact laws. Figure 21 uses equations (15), (20), (16) and (24) to represent this interrelationship for Materials 1 and 2. It is worth noting that this interrelationships can not only be used to design a material with targeted quality attributes (see, e.g., [75,78,59,60,61]) but it can also be used to control the manufacturing process to assure such quality attributes are achieved (see, e.g., [74]).…”

Section: Microstructure-mediated Process-structure-property-performanmentioning

confidence: 99%

“…It is then the formation of an interconnected network of solid bridges that enables strength formation in the solid compact. The strength of these solid bridges will vary from material to material depending on the forces that hold the (poly)crystals and amorphous solids together [63,16,49,3]. It is worth noting that this process is irreversible, and thus it is not possible to divide the compacted system into its original particles.…”

Section: Introductionmentioning

confidence: 99%

Generalized loading-unloading contact laws for elasto-plastic spheres with bonding strength

Gonzalez¹

2019

Journal of the Mechanics and Physics of Solids

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We present generalized loading-unloading contact laws for elasto-plastic spheres with bonding strength. The proposed mechanistic contact laws are continuous at the onset of unloading by means of a regularization term, in the spirit of a cohesive zone model, that introduces a small and controllable error in the conditions for interparticle breakage. This continuity property is in sharp contrast with the behavior of standard mechanistic loading and unloading contact theories, which exhibit a discontinuity at the onset of unloading when particles form solid bridges during plastic deformation. The formulation depends on five material properties, namely two elastic properties (Young's modulus and Poisson's ratio), two plastic properties (a plastic stiffness and a power-law hardening exponent) and one fracture mechanics property (fracture toughness), and its predictions are in agreement with detailed finite-element simulations. The numerical robustness and efficiency of the proposed formulation are borne out by performing three-dimensional particle mechanics static calculations of microstructure evolution during the three most important steps of powder die-compaction, namely during compaction, unloading, and ejection. These simulations reveal the evolution, up to relative densities close to one, of microstructural features, process variables and compact mechanical attributes which are quantitatively similar to those experimentally observed and in remarkable agreement with the (semi-)empirical formulae reported in the literature.

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“…The solid surfaces of pharmaceutical materials are typically not perfectly clean and crystalline; they often exhibit surface roughness, defects, and impurities that introduce high-energy binding sites that serve as preferential binding sites during water adsorption. The presence of these high-energy binding sites has been shown to be related to greater than expected amounts of water uptake [21,22].…”

Section: Liquid Adsorption At the Solid Surfacementioning

confidence: 99%

The dehydration of pharmaceutical hydrates under mechanical load

Friedman¹

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for your friendship and welcome distractions.My future in-laws, Martin and Della, for their continued encouragement and for treating me like family while I was away from my own. Uncle Barry for being a great friend and a big brother to me, RIP.Chad for being the best little brother a guy could ask for.My Mom and Dad for their endless love, support, and encouragement.Ana for her friendship, love, support, devotion, and unlimited source of happiness from the first day that I met her. v TABLE OF CONTENTS LIST OF TABLES…………………………………………………………………………………………….………………viii LIST OF FIGURES…………………………………………………………………………………………………………….xi CHAPTER 1. BACKGROUND AND INTRODUCTION…………………………………………………………..1

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The effect of interparticulate friction and moisture on the crushing strength of sodium chloride compacts

Cited by 35 publications

References 10 publications

Bonding Surface area and Bonding Mechanism-Two Important Factors fir the Understanding of Powder Comparability

Bonding Surface area and Bonding Mechanism-Two Important Factors fir the Understanding of Powder Comparability

Generalized loading-unloading contact laws for elasto-plastic spheres with bonding strength

The dehydration of pharmaceutical hydrates under mechanical load

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