The aim of this systematic review was to analyze the acute and chronic effects of
sitting breaks on cardiovascular parameters. PubMed and Web of Science databases
were searched by two independent researchers for relevant studies published
until February 2020. Acute or chronic studies reporting the effects of sitting
breaks or reduction in sitting time on cardiovascular parameters were examined.
The eligibility criteria followed PICOS: Population - Humans ≥ 18 years
old; Interventions – Sitting break strategies; Comparisons –
Uninterrupted sitting; Outcomes – Cardiovascular parameters (blood
pressure, heart rate, ambulatory blood pressure, vascular function, pulse-wave
velocity, cerebral blood flow and biomarkers); Study design – Randomized
controlled trials, non-randomized non-controlled trials and randomized crossover
trials. Forty-five studies were included, where 35 investigated the acute and 10
the chronic effects of sitting breaks or reductions in sitting time. Walking was
the main acute study strategy, used in different volumes (1 min
30 s to 30 min), intensities (light to vigorous) and frequencies
(every 20 min to every 2 h). Acute studies found improvements on
cardiovascular parameters, especially blood pressure, flow-mediated dilation,
and biomarkers, whereas chronic studies found improvements mostly on blood
pressure. Breaking up or reducing sitting time improves cardiovascular
parameters, especially with walking.