The Effect of Intestinal Reperfusion on Renal Function and Perfusion

Oxymatrine attenuates intestinal ischemia/reperfusion injury in rats

“…1 During I/R, tissues are subjected to the destructive proinfl ammatory cytokines and reactive oxygen species released by infl ammatory cells, leading to infl ammatory injury and cell apoptosis. 2,3 Intestinal I/R can also cause injury to the secondary organs [4][5][6][7] and even multiple organ failure (MOF). Therefore, novel agents to attenuate intestinal I/R are being sought urgently.…”

Taurine Attenuates Multiple Organ Injury Induced by Intestinal Ischemia Reperfusion in Rats

“…During ischemia reperfusion (I/R), tissues are subjected to the destructive proinflammatory cytokines and reactive oxygen species released by inflammatory cells, leading to inflammatory injury and cell apoptosis [2,3]. II/R also affects the secondary organs, including liver [4], heart [5], kidney [6], and lung [7], and even causes multiple organ failure (MOF), a common cause of mortality. Therefore, seeking anti-oxidative, anti-inflammatory, and antiapoptotic agents to attenuate multiple organ injury induced by II/R is urgently required.…”

Heart energy metabolism after intestinal ischaemia and reperfusion

“…1 Multiple organ failure is a common life-threatening complication of intestinal I/R and is believed to account for a significant percentage of morbidity and mortality connected to this condition. [2][3][4][5] It is associated with involvement of the liver, 6,7 heart, 8,9 kidney, 10 and lungs. 7,11,4 A marked deficit of cardiac performance with dysfunction in myocardial contraction and relaxation has been reported as a consequence of intestinal I/R in experimental animals that could perpetuate the existing intestinal hypoperfusion.…”