The Effect of Intra-Amniotic Injection of Hypertonic Saline on the Structure and Endocrine Function of the Human Placenta

Studies on the Mode of Action of Intra‐Amniotically and Extra‐Amniotically Injected Hypertonic Saline in Therapeutic Abortion

“…This hypothesis has been debated. Although subchorionic necrosis of villi has been found by various investigators (Strauss 1963, Weingold et al 1965, Wynn 1965, Christie et d. 1966, Gochberg & Reid 1966, Pathak 1968, Jakobovits et al 1970, the changes are believed to be far too limited to have any definite effect on the placental hormone production (Wynn 1965, Christie et al 1966. Some workers (Wiest et al 1966, Wiest 1967, Csapo et al 1969, Holmdahl et al 1971) have confirmed the decrease in peripheral plasma progesterone, though Holmdahl et al (1971) could not find any correlation between this decrease and the onset of abortion.…”

“…Effect on the decidua Most reports of histological examination of the placenta after intrauterine injection of hypertonic saline do not mention the decidua (Bengtsson & Stormby 1962, Oram et al 1963, Sciarra et al 1964, Weingold et al 1965, Wynn 1965, Christie et al 1966, Gochberg & Reid 1966, Pathak 1968, Jakobovits et al 1970, Blaustein & Shenker 1971. Jaffin et al (1962) found "no microscopic evidence of .…”

Histological Appearances of the Human Placenta Observed by Electron Microscopy After Hypertonic Saline Abortion

“…The third field of controversy concerns the results of microscopic examination of the placenta after hypertonic saline abortion. Several investigators have found lesions of the subchorionic layer of the placenta (2,4,10,13), the most extensive investigations having been made by Christie et al (4). These authors observed characteristic lesions in 14 placentae after intraamniotic injection of hypertonic saline.…”

Placental Pathology in Midtrimester Pregnancies Interrupted by Intra‐amniotic Injection of Hypertonic Urea

“…Histological examination of the afterbirth has either been negative (Jakobovitz et al, 1970), or has shown villi with prominent intervillous thrombosis (Bengtsson and Stormby, 1962;Jaffin et al, 1962). and oedema of the membranes (Christie et al, 1966), after saline-induced abortion.…”