2012
DOI: 10.4103/0019-509x.102918
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The effect of intraarterial high-dose cisplatin on lymph nodes in oral and oropharyngeal cancer

Abstract: A regional effect of intraarterial cisplatin is proven. To date, it is not clear whether this is due to decreasing inflammatory reaction or a translymphatic anti-neoplastic effect.

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Cited by 5 publications
(3 citation statements)
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“…Shrinkage of enlarged lymph nodes, as observed by us, corroborate with other studies. [9] Similarly, subjective improvement in terms of alleviation of pain, reduction of salivation and drooling, decrease in foul odor and reduction of trismus was observed in our studies, similar to others. [10] Most patients showed regression of the tumor after a follow up of 6 months, thus indicating the effectiveness of the combination therapy.…”
Section: Discussionsupporting
confidence: 92%
“…Shrinkage of enlarged lymph nodes, as observed by us, corroborate with other studies. [9] Similarly, subjective improvement in terms of alleviation of pain, reduction of salivation and drooling, decrease in foul odor and reduction of trismus was observed in our studies, similar to others. [10] Most patients showed regression of the tumor after a follow up of 6 months, thus indicating the effectiveness of the combination therapy.…”
Section: Discussionsupporting
confidence: 92%
“…An i.a. bolus injection, usually applied with very high cisplatin dosages (100 mg/m 2 ), reaches high local concentrations during a brief infusion time of less than 1 min, which are decreased by thiosulfate (Robbins et al 2010; Kovacs et al 2012). An i.a.…”
Section: Introductionmentioning
confidence: 99%
“…Second, the exact technique of i.a. infusion is crucial for the outcome, and former studies have not always been optimal in terms of catheter position, concentration, and time of chemo exposure (Robbins et al 2010; Kovacs et al 2012; Rasch et al 2010). …”
Section: Introductionmentioning
confidence: 99%