The effect of intraarticular combinations of tramadol and ropivacaine with ketamine on postoperative pain after arthroscopic meniscectomy

Abstract

Administration of intraarticular tramadol-ketamine combination was found to be more effective in decreasing postoperative daily analgesic consumption.

The efficacy of adductor canal blockade after minor arthroscopic knee surgery – a randomised controlled trial

“…Our sample size estimation was based upon the assumption, derived from results from previous studies, that patients in the placebo group would have a VAS score regarding our primary outcome of approximately 40 (SD 25) mm. [14][15][16][17][18] The observed VAS scores in our trial were, however, considerably lower, the median pain scores for patients at standing, 2 h after ACB, being 15 vs. 17 mm in the ropivacaine and the control group, respectively. Therefore, the fact that we could not detect a potential difference between the VAS scores in the randomised groups may be due to insufficient assay sensitivity.…”

“…There were no statistically significant differences between groups for AUC (weighted average level) regarding pain at rest (0-24 h): 10 (1-23) vs. 13 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) Regarding levels of dizziness, sedation and nausea, number of vomits, number of patients vomiting and consumption of ondansetron, there were no significant differences at any time points between groups.…”

“…[14][15][16][17][18] We considered a 50% reduction (20 mm) to be of clinical relevance. With a type I error (α) of 5% and a power (1-β) of 90%, a sample size of 68 patients, 34 in each group, would be required.…”

Efeitos da associação de tiletamina/zolazepam ou cetamina S(+)/midazolam/tramadol para contenção química em bugios-ruivos (Allouatta guariba clamitans)

“…Entretanto, neste estudo não se utilizou métodos para se determinar o grau de analgesia do protocolo, pois o reflexo ao pinçamento discutido anteriormente reflete a sedação e os reflexos motores e não a qualidade analgésica (Monteiro et al 2009). Embora encontre se estudos em humanos (Ayoglu et al 2010) e suínos (Ajadi et al 2009) que comprovem a associação benéfica da cetamina com o tramadol para aumentar o grau de analgesia dos pacientes, ainda são necessários mais estudos com relação à utilização e dosagem do tramadol em espécies selvagens. Em relação ao tempo total de sedação (38±7min no TZ e 48±4min no CEMTRA) e tempo de recuperação total (150±42min no CEMTRA e de 73±20min no TZ), observou se maiores valores no grupo CEMTRA, diferindo estatisticamente do grupo TZ.…”

Tratamiento con enjuagues de ketamina asociado o no a fentanilo transmucoso en el dolor oncológico orofacial resistente a opiáceos mayores

“…Los receptores tipo NMDA se hallan ampliamente repartidos por el sistema nervioso y la administración a nivel periférico de diversos fár-macos antagonistas de los receptores NMDA poseen diversas acciones antiinflamatorias y antinociceptivas 8,9 . Las vías de administración del clorhidrato de ketamina, antagonista de los receptores NMDA, son múltiples [10][11][12][13][14][15] .…”