The effect of intracerebroventricular injection of beta amyloid peptide (1-42) on caspase-3 activity, lipid peroxidation, nitric oxide and nos expression in young adult and aged rat brain

Çetin, Ferihan; Yazıhan, Nuray; Dinçer, Sibel; Akbulut, Gonca

doi:10.5137/1019-5149.jtn.5855-12.1

Cited by 33 publications

(25 citation statements)

References 13 publications

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“…In our study, Aβ administration increased lipid peroxidation as shown by a higher level of MDA and lowered SOD activity as an antioxidant system. These results support previous findings that reported significantly increased level of MDA in rodents after injection of Aβ (Cetin et al, 2013). However, there are much controversy on SOD changes in AD models.…”

Section: Discussionsupporting

confidence: 92%

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

Ghofrani

Joghataei

Mohseni

et al. 2015

European Journal of Pharmacology

151

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Alzheimer's disease (AD) is one of the prevalent neurological disorders of the central nervous system hallmarked by increased beta-amyloid (Aβ) deposition and ensuing learning and memory deficit. In the present study, the beneficial effect of naringenin on improvement of learning and memory was evaluated in an Alzheimer's disease rat model. The Aβ-injected rats showed a lower alternation score in Y-maze task, impairment of retention and recall capability in passive avoidance test, and lower correct choices and higher errors in radial arm maze (RAM) task as compared to sham group in addition to enhanced oxidative stress and apoptosis. Naringenin, but not a combination of naringenin and fulverstrant (an estrogenic receptor antagonist) significantly improved the performance of Aβ-injected rats in passive avoidance and RAM tasks. Naringenin pretreatment of Aβ-injected rats also lowered hippocampal malondialdehyde (MDA) with no significant effect on nitrite and superoxide dismutase (SOD) activity in addition to lowering apoptosis. These results suggest naringenin pretreatment attenuates Aβ-induced impairment of learning and memory through mitigation of lipid peroxidation and apoptosis and its beneficial effect is somewhat mediated via estrogenic pathway.

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Section: Discussionsupporting

confidence: 92%

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

Ghofrani

Joghataei

Mohseni

et al. 2015

European Journal of Pharmacology

151

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“…In this study, intracerebroventricular administration of Aβ showed a significant impairment in learning and memory, which was in line with other studies (7,47).…”

Section: Discussionsupporting

confidence: 80%

Intranasal insulin treatment improves memory and learning in a rat amyloid-beta model of Alzheimer’s disease

Farzampour¹,

Majdi²,

Sadigh-Eteghad³

2016

Physiology International

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Recently, insulin has been used as a pro-cognitive agent for the potential treatment of Alzheimer's disease (AD), because of its ability to cross the brain-blood barrier (BBB) by a saturable transport system. This study has been designed to evaluate the effects of intranasal insulin regimen, as a bypass system of BBB, on spatial memory in amyloid-beta (Aβ) model of AD in rat. Unilateral infusion of Aβ 25-35 (10 nmol/2 μl/rat) into the lateral ventricular region of brain was used to produce a rat model of AD. After a 24-h recovery period, rats received insulin or vehicle via intraperitoneal or intranasal route (0.1, 0.2, and 0.3 IU) for 14 days. Memory function in rats was assessed by Morris water maze test, with 5 days of training and consequent probe test protocol. Different doses of intraperitoneal insulin did not have a significant effect on learning and memory in AD rats. However, intranasal insulin at doses of 0.2 and 0.3 IU improved the learning and memory in Aβ-received rats.In conclusion, intranasal insulin as a non-invasive strategy improves spatial learning and memory in AD model.

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“…Previous research also confirmed that cell apoptosis after epilepsy was related to overexpression of NO, which demonstrated that iNOS was more closely related with apoptosis (22). Another study demonstrated that a selective iNOS inhibitor could significantly reduce the expression of caspase-3 (23). The results of the current study suggested that geniposide treatment did not significantly affect iNOS mRNA expression in mouse epilepsy.…”

Section: Discussionsupporting

confidence: 74%

Geniposide attenuates epilepsy symptoms in a mouse model through the PI3K/Akt/GSK‑3β signaling pathway

Wei¹,

Duan²,

He³

et al. 2017

Exp Ther Med

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Abstract. Previous reports on the pharmacological actions of geniposide have indicated that it has anti-asthmatic, anti-inflammatory and analgesic effects in the liver and gallbladder, and therapeutic effects in neurological, cardiovascular and cerebrovascular diseases. The results of the current study demonstrate that geniposide attenuates epilepsy in a mouse model through the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/glycogen synthase kinase-3β (GSK-3β) signaling pathway. A mouse model of epilepsy was induced by maximal electric shock (50 mA, 50 Hz, 1 sec). Epilepsy mice were intragastrically administered with 0, 5, 10 or 20 mg/kg geniposide. Geniposide significantly reduced the incidence and significantly increased the latency of clonic seizures in epileptic mice compared with non-treated epileptic mice (both P<0.01). Geniposide treatment significantly inhibited cyclooxygenase-2 mRNA expression in epilepsy mice (P<0.01). Furthermore, geniposide significantly suppressed the protein expression of activator protein 1, increased the activation of Akt and increased the protein expression of GSK-3β and PI3K in epilepsy mice (all P<0.01). These results suggest that geniposide attenuates epilepsy in mice through the PI3K/Akt/GSK-3β signaling pathway.

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The effect of intracerebroventricular injection of beta amyloid peptide (1-42) on caspase-3 activity, lipid peroxidation, nitric oxide and nos expression in young adult and aged rat brain

Cited by 33 publications

References 13 publications

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

Intranasal insulin treatment improves memory and learning in a rat amyloid-beta model of Alzheimer’s disease

Geniposide attenuates epilepsy symptoms in a mouse model through the PI3K/Akt/GSK‑3β signaling pathway

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