The effect of intranasal salmon calcitonin therapy on bone mineral density in idiopathic male osteoporosis without vertebral fractures—An open label study

Tóth, Edit; Csupor, Emőke; Mészáros, Szilvia; Ferencz, Viktória; Németh, Lóránd; McCloskey, Eugène; Horváth, Csaba

doi:10.1016/j.bone.2004.09.003

Cited by 39 publications

(20 citation statements)

References 22 publications

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“…Intranasal calcitonin decreased biochemical markers of bone turnover and had a beneficial effect on spine BMD (238). Studies of the effectiveness of intranasal calcitonin in men include one openlabel study (239) that suggested that therapy reduced the risk of vertebral fracture.…”

Section: Calcitoninmentioning

confidence: 98%

Osteoporosis in Men

2008

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With the aging of the population, there is a growing recognition that osteoporosis and fractures in men are a significant public health problem, and both hip and vertebral fractures are associated with increased morbidity and mortality in men. Osteoporosis in men is a heterogeneous clinical entity: whereas most men experience bone loss with aging, some men develop osteoporosis at a relatively young age, often for unexplained reasons (idiopathic osteoporosis). Declining sex steroid levels and other hormonal changes likely contribute to age-related bone loss, as do impairments in osteoblast number and/or activity. Secondary causes of osteoporosis also play a significant role in pathogenesis. Although there is ongoing controversy regarding whether osteoporosis in men should be diagnosed based on female- or male-specific reference ranges (because some evidence indicates that the risk of fracture is similar in women and men for a given level of bone mineral density), a diagnosis of osteoporosis in men is generally made based on male-specific reference ranges. Treatment consists both of nonpharmacological (lifestyle factors, calcium and vitamin D supplementation) and pharmacological (most commonly bisphosphonates or PTH) approaches, with efficacy similar to that seen in women. Increasing awareness of osteoporosis in men among physicians and the lay public is critical for the prevention of fractures in our aging male population.

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Section: Calcitoninmentioning

confidence: 98%

Osteoporosis in Men

2008

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“…Likewise, in men with idiopathic osteoporosis without vertebral fractures nasal salmon calcitonin (200 IU/day at monthly intervals) produced significant increments in bone density at the lumbar spine and femoral neck, but not at the radius, after 18 months, compared to no changes in bone density in subjects taking only calcium and vitamin D [99]. Despite these positive results, lack of larger-scale trials has precluded consideration of calcitonin for FDA approval for osteoporosis in men.…”

Section: Osteoporosis In Menmentioning

confidence: 74%

Calcitonin in Osteoporosis

Civitelli

2013

Osteoporosis

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“…Trovas et al [11] also found no change in femoral neck BMD with nasal salmon calcitonin in men. On the other hand, Toth et al showed that 200 IU of intranasal calcitonin daily for one year produced an increase in BMD at lumbar spine and femoral neck [14]. Some osteoporotic patients may report pain, particularly in their back.…”

Section: Discussionmentioning

confidence: 95%