The effect of intraosseous sodium bicarbonate on bone in swine

Spivey, William H; Unger, Henry D.; McNamara, Robert M.; LaMANNA, Margaret M.; Ho, Teh; Lathers, Claire M.

doi:10.1016/s0196-0644(87)80572-3

Cited by 28 publications

(6 citation statements)

References 6 publications

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“…This same trend was observed by Spivey and colleagues who compared IO and IV administration of diazepam in swine. Diazepam plasma levels were higher after IV for the first 5 minutes following administration but were less than IO for the remainder of the 20-minute experiment 16, 17. This trend has not been observed in all studies.…”

Section: Discussionmentioning

confidence: 74%

Onset and Duration of Intravenous and Intraosseous Rocuronium in Swine

Loughren¹,

Banks²,

Naluan³

et al. 2014

WestJEM

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IntroductionThe intraosseous (IO) route has become a popular method to gain access to the peripheral circulation in emergency situations. Despite little supporting data, it is generally believed that IO absorption is immediate and equivalent to the intravenous (IV) route. It is important to determine if rocuronium can effectively be administered by the IO route. The aim of the study was to determine and compare the onset and duration of rocuronium when administered via the IO and IV routes in a normovolemic pig model.MethodsWe recorded electromyographic (EMG) data following tibial IO and peripheral IV administration of rocuronium (1.2 mg/kg) in 10 swine weighing between 56 and 71 Kg. We transformed data were transformed to percent of baseline, determined onset and recovery characteristics.ResultsThe onset EMG-time profiles for IO and IV administration were very similar: tibial IO compared to IV administration did not statistically alter the onset of paralysis. The IO group took statistically longer than the IV group to return to 50 (p=0.042), 75 (p=0.034) and 95 (p=0.036) percent of baseline activity.ConclusionThe duration of effect is statistically longer after IO administration but is more of an academic interest than a clinical concern. The results of this study suggest that rocuronium can effectively be administered via the IO route without the need for dose adjustments.

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Section: Discussionmentioning

confidence: 74%

Onset and Duration of Intravenous and Intraosseous Rocuronium in Swine

Loughren¹,

Banks²,

Naluan³

et al. 2014

WestJEM

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“…Intraosseous needles were placed in young growing pigs, and pigs were observed for 1, 3, or 6 months; no clinical abnormalities were reported. 9,[37][38][39] The only clinical abnormality detected in our study was a firm, raised nodule at the site of IO needle puncture in 2 pigs. A similar finding was reported in children 30 to 40 days following IO infusion.…”

Section: Discussionmentioning

confidence: 50%

“…40 Others have also reported similar lesions in pigs that received sodium bicarbonate intraosseously; these lesions resolved within 60 days. 39 In several previous studies in which IO needles were used for sample collection, histologic evaluation of bones was not reported. [28][29][30][31][32][33] However, results of other studies in which IO infusions were administered to humans and other animals revealed no histologic abnormalities, 18 decreased marrow cellularity, 10,37,j mild focal fibrosis, 9 or marrow degeneration and fat necrosis.…”

Section: Discussionmentioning

confidence: 99%

Use of intraosseous blood for repeated hematologic and biochemical analyses in healthy pigs

Greco¹,

Talcott²,

LaRegina³

et al. 2001

ajvr

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“…First, experimental [15][16][17][18] studies which examined macroscopic and histologic bony damage some weeks after intraosseous infusion and second clinical studies 1-4 which followed radiologically tibial length within a follow-up time younger than or equal to 2 years. In this first group, the only macroscopic and histologic findings were minimal damage to the cells surrounding the injection site.…”

Section: Discussionmentioning

confidence: 99%

“…Cells and supporting bony matrix elsewhere appeared normal. 2,[15][16][17][18] Even in the Brickman et al study, 18 which involved direct damage to the growth plate in a pig model, there was no radiographic evidence of growth abnormalities 6 months later.…”

Section: Discussionmentioning

confidence: 99%