The effect of intravenous administration of melatonin on cardiovascular parameters of the baboon (<i>Papio ursinus</i>)

Bosnian, H.; Dormehl, I. C.; Hugo, N.; Redelinghuys, I. F.; Theron, Jacques

doi:10.1111/j.1600-079x.1991.tb00476.x

Cited by 16 publications

(13 citation statements)

References 8 publications

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“…Some reports have shown that melatonin also lowers heart rate (15). Using interval microprocessor analysis of the electrocardiogram, Wynn and Arendt (18) showed that melatonin had the effect of lengthening the RR interval and delaying the onset of the R wave.…”

Section: Discussionmentioning

confidence: 98%

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Melatonin Reduces 3H-Nitrendipine Binding in the Heart

Chen

Kumar

Reíter

et al. 1994

Experimental Biology and Medicine

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The effect of melatonin on cardiac and brain voltage-sensitive calcium channels, as measured by 3H-nitrendipine binding, was examined in rats 3 hr after melatonin administration (either 0.5 or 1.0 mg/kg given subcutaneously). Scatchard analysis of the data on specific binding of 3H-nitrendipine with crude cardiac membranes from melatonin treated rats revealed significant decreases (P < 0.05 and P < 0.01 for the 0.5 and 1.0 mg/kg melatonin doses, respectively) in the density of Ca2+ channels without a change in their affinity for the ligand. At doses of 0.5 and 1.0 mg/kg of melatonin, Bmax values were 157 and 142 fmoles/mg protein, respectively, compared with a control value of 199 fmoles/mg protein in crude cardiac membranes. In brain, melatonin treatment did not statistically significantly influence either 3H-nitrendipine binding or its affinity when compared with control animals. These results suggest that melatonin modulates the functional status of voltage sensitive calcium channels in the heart, changes that may have implications for normal cardiac physiology and for the pharmacological manipulation of the heart.

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Section: Discussionmentioning

confidence: 98%

“…This action of melatonin may account for some of its effects on the cardiovascular system. The cardiovascular effects of melatonin include an action on the electrical activity of the heart and on the calcium pump in cardiomyocytes (15)(16)(17)(18). Herein, we report that melatonin also influences voltage-sensitive calcium channels in the heart.…”

mentioning

confidence: 89%

Melatonin Reduces 3H-Nitrendipine Binding in the Heart

Chen

Kumar

Reíter

et al. 1994

Experimental Biology and Medicine

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“…Cardiovascular effects of exogenous and endogenous melatonin could favor exercise performance. Thus, intravenous administration of melatonin in the baboon increases the cardiac output and left ventricular ejection fraction, which implies a positive inotropic action on the heart by melatonin that could increase cardiac output [60]. Measurements of salivary melatonin concentration during and after exercise show that the gradient of the heart rate–melatonin relationship is steeper in the morning than in the afternoon [44].…”

Section: Melatonin and Physical Performancementioning

confidence: 99%

Exercise and melatonin in humans: reciprocal benefits

Escames

Öztürk

Baño-Otálora

et al. 2011

Journal of Pineal Research

119

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: The aim of this review is to update the reader as to the association between physical exercise and melatonin, and to clarify how the melatonin rhythm may be affected by different types of exercise. Exercise may act as a zeitgeber, although the effects of exercise on the human circadian system are only now being explored. Depending on the time of the day, on the intensity of light, and on the proximity of the exercise to the onset or decline of the circadian production of melatonin, the consequence of exercise on the melatonin rhythm varies. Moreover, especially strenuous exercise per se induces an increased oxidative stress that in turn may affect melatonin levels in the peripheral circulation because indole is rapidly used to combat free radical damage. On the other hand, melatonin also may influence physical performance, and thus, there are mutually interactions between exercise and melatonin production which may be beneficial.

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“…However, the influence of melatonin on gastric microcirculation and intestinal barrier function in acute disease, such as shock, has not been investigated yet. Furthermore, although melatonin has demonstrated its protective potential in rodents, data on intravenous bolus application in larger species than rodents are sparse . Therefore, the objective of this study was to test the hypothesis that pretreatment with melatonin may influence gastric mucosal microcirculation and oxygen delivery, as well as xylose absorption as a parameter of intestinal barrier function, during hemorrhagic shock in a randomized crossover investigation in dogs.…”

Section: Introductionmentioning

confidence: 99%