The effect of intravenous aminophylline on the capacity for effort without pain in patients with angina of effort

Bakst, Hyman; Kissin, Milton; Leibowitz, Sidney; Rinzler, Seymour H.

doi:10.1016/0002-8703(48)90689-9

Cited by 19 publications

(10 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors also noted: 'Whether saline injection alone produces any increase in the capacity for effort, through suggestion or other means, was not determined because the number of suitable tests for such a comparison was too small' (Bakst et al, 17 p. 533).…”

Section: Harry Gold and Researcher Blindingmentioning

confidence: 99%

The (Harry) Gold standard: angina, suggestion and the path to the ‘double blind’ test and clinical pharmacology. Part 2: the path to the ‘double blind’

Podolsky

2023

J R Soc Med

View full text Add to dashboard Cite

Section: Harry Gold and Researcher Blindingmentioning

confidence: 99%

The (Harry) Gold standard: angina, suggestion and the path to the ‘double blind’ test and clinical pharmacology. Part 2: the path to the ‘double blind’

Podolsky

2023

J R Soc Med

View full text Add to dashboard Cite

“…It has been found in angina pectoris that the exercise tolerance may vary considerably from day to day (17). We were interested, therefore, to determine whether such day to day variation occurred in intermittent claudication.…”

Section: Constancy Of the End Pointmentioning

confidence: 99%

A Two-Step Test of Exercise Tolerance in Intermittent Claudication

Kissin¹,

Stein²,

Adleman³

1950

Angiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Further, we are not prepared to state the effect of oral administration. Certainly, in angina, oral administration was found to be ineffective (1), although intravenously the exercise tolerance was found to increase in angina pectoris (21,22). SUMMARY The effect of nitroglycerin, papaverin, ethyl alcohol, depropanex, niacin, histidine with ascorbic acid, paravertebral block, cytochrome-C, methylene blue and aminophyllin on the exercise tolerance of patients with intermittent claudication due to arteriosclerosis was studied, using a &dquo;blind&dquo; technique with placebo control.…”

Section: Aminophyllin (Theophylline With Ethylene Diamine)mentioning

confidence: 99%

The Effect of Drugs Used in the Treatment of Inter Mittent Claudication On the Exercise Tolerance of Individuals With Obliterating Arteriosclerosis

1951

Self Cite

View full text Add to dashboard Cite

In earlier studies on intermittent claudication (1), we found that the exercise tolerance, as measured by the two-step test, remained constant when repeated at intervals on a single day. We then proceeded to a study of the effect of drugs used in the treatment of intermittent claudication. This paper, which reports the study, is concerned only with acute experiments done on a single day.The subjects varied in age from 49 to 77 years. Their intermittent claudication was caused by arteriosclerosis. Each drug was tested on ten patients, except aminophyllin, which was tested on twenty. A &dquo;blind&dquo; technique was used. In this technique, neither the patient nor the observer knows whether the drug or control substance is being tested. Written and sealed codes were drawn up in advance to record the order of administration of drugs tested. These codes were not examined until the experiments were completed. Half the experiments were done with the drug studied being given first and half with the control substance first. Before giving either medication or placebo, two to four measurements of exercise tolerance were made at fifteen minute intervals. We then gave substance § 1 (that is, either the drug or a placebo) and made four more measurements of exercise tolerance at fifteen minute intervals. We then gave substance # 2, which was also placebo or drug, and made four measurements. Altogether we made 10 or 12 measurements of exercise tolerance, 2 to 4 without medication, 4 after the drug being tested, and 4 after the control substance.Of course, it was not always possible to keep the patient unaware of the difference between drug and placebo. Ethyl alcohol given as whisky scarcely tasted the same as weak tea, the control substance. Methylene blue actually colored the patient blue. Niacin caused flushing of the face. Nitroglycerin occasionally caused headache. The tests were then made by a different observer than the one who gave the drug. Also, colored injections, such as methylene blue and cytochrome-C, were injected with the subject's arm screened from his eyes. In testing histidine and ascorbic acid, we made no control injections because of the long duration of the experiments. With that combination of drugs, we merely compared exercise tolerances before and after the injections.The effects of the following were studied: nitroglycerin, papaverin, ethyl alcohol, depropanex, niacin, histidine with ascorbic acid, paravertebral block, cytochrome-C, methylene blue and aminophyllin.

show abstract

The effect of intravenous aminophylline on the capacity for effort without pain in patients with angina of effort

Cited by 19 publications

References 8 publications

The (Harry) Gold standard: angina, suggestion and the path to the ‘double blind’ test and clinical pharmacology. Part 2: the path to the ‘double blind’

The (Harry) Gold standard: angina, suggestion and the path to the ‘double blind’ test and clinical pharmacology. Part 2: the path to the ‘double blind’

A Two-Step Test of Exercise Tolerance in Intermittent Claudication

The Effect of Drugs Used in the Treatment of Inter Mittent Claudication On the Exercise Tolerance of Individuals With Obliterating Arteriosclerosis

Contact Info

Product

Resources

About