The Effect of Intravenous Citalopram on the Neural Substrates of Obsessive-Compulsive Disorder

Bhikram, Tracy; Farb, Norman A. S.; Ravindran, Lakshmi N.; Papadopoulos, Yousef G.; Conn, David; Pollock, Bruce G.; Ravindran, Arun

doi:10.1176/appi.neuropsych.15090213

Cited by 7 publications

(2 citation statements)

References 13 publications

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“…Other studies, using MRI, have reported decreased amygdala and temporal volumes in adolescent patients (Gilbert et al, 2000;Szeszko et al, 2004). A recent crossover study using intravenous citalopram during symptom provocation in eight OCD patients and eight healthy controls found that citalopram resulted in less OFC activation, which correlated with reductions in state anxiety (Bhikram et al, 2016).…”

Section: Treatment Effects On the Brainmentioning

confidence: 98%

Effects of Bergen 4-Day Treatment on Resting-State Graph Features in Obsessive-Compulsive Disorder

Thorsen

Vriend

Wit

et al. 2021

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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It takes a village to raise a child and even more to raise a scientist, and this thesis would not be possible without years of work by my supervisors. I wish to thank Gerd Kvale and Bjarne Hansen for bothering to answer an email from me, a naïve psychology student, in November 2013. I had just received an offer to revise and resubmit my first article by a slightly confused editor who probably didn't understand what to do with a review paper written by a student with no supervisor. Gerd and Bjarne decided to give me a chance to work as a research assistant, which became the first building block of my PhD and our first paper together (Thorsen, van den Heuvel, Hansen, & Kvale, 2015). I wish to thank Bjarne and Gerd for showing how to combine being a caring person, clinician, and scientist. In addition, I thank them for trusting eager new students with important work and for guiding both patients and students to help them prosper. I wish to thank Odile van den Heuvel for her kind, intensive, generous, and enlightening guidance on how to combine living a good life and doing science. I remember travelling to Amsterdam for the first time in June 2014, then an eager and anxious 23-year old. However, my anxiety was soon lifted by Odile, the members of her research group, and her lovely family. I especially wish to thank her for her utmost generosity in inviting to me to live with her and her family for many of my visits to Amsterdam. Words cannot express my gratitude to my supervisors, and I look forward to working and spending time together in the future. I wish to thank my family and friends which make both life and work meaningful. I especially wish to thank Stella J. de Wit for guidance, discussions, and lots of fun throughout my PhD. I also thank her for inviting me to get to know her dear family. My visits to Weesp are very dear to me,

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Section: Treatment Effects On the Brainmentioning

confidence: 98%

Effects of Bergen 4-Day Treatment on Resting-State Graph Features in Obsessive-Compulsive Disorder

Thorsen

Vriend

Wit

et al. 2021

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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“…Most recently, Bhikram et al studied the effect of an intravenous serotonin reuptake inhibitor, citalopram, on the neural substrates of OCD, to test its efficacy in OCD treatment compared to conventional psychopharmacotherapy in a small number of OCD patients and healthy comparisons during fMRI investigation. They reported that OCD patients exhibited meaningful alterations in neural activity at prefrontal region after citalopram administration intravenously than those who received placebo, and these alterations were correlated with reductions in subjective anxiety [30]. By using proton magnetic resonance spectroscopic imaging, Jang et al studied regional Nacetylaspartate (NAA) levels before and after twelve weeks of period in patients being treated with citalopram and demonstrated that OCD patients had significantly reduced NAA values in some cortical areas such as prefrontal cortex, frontal white matter, and anterior cingulate at the beginning of the study compared to healthy controls, with particular raises in NAA values in the prefrontal cortex and frontal white matter in OCD patients after medication period [31].…”

Section: Functional Neuroimaging Studiesmentioning

confidence: 99%

Functional and Structural Neural Changes in Obsessive-compulsive Disorder after Pharmacotherapy

Atmaca

2019

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Obsessive-compulsive disorder (OCD) is a disorder which is important and disturbing the quality of life and is characterized by repetitive thoughts and behaviors, now in a different category in the Diagnostic and Statistical Manual for Mental Disorders Fifth Edition (DSM 5). Neuroimaging investigations are very useful to reveal a neurobiological model of the OCD. Studies conducted in the last quarter century have shown clear results and revealed that specific cortico-subcortical circuits could be involved in the occurrence of OCD symptomatology. These neuroimaging studies pointed out some important findings for OCD patients. Our present information implicates some problems in some cortico-subcortical in the pathophysiology of OCD. In the present paper, it was reviewed final information on the neuroanatomy and neurochemistry of OCD, revising the effects of anti-obsessional drugs on the structural and functional neuroimaging studies. As can be seen in the review, drug treatments can generally affect the brain structurally and functionally, suggesting that brain of OCD tends to neuroplasticity. However, it is not clear that these effects of pharmacotherapy are related to anti-obsessional drugs per se or impact on the improvement of the disorder.

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Depression and Anxiety Disorders

2021

The Maudsley Prescribing Guidelines in Psychiatry

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Depression is widely recognised as a major public health problem around the world. The basic principles of prescribing are described in this chapter, along with a summary of NICE guidance. This chapter concentrates on the use of antidepressants and offers advice on drug choice, dosing, switching strategies and sequencing of treatments. Management of treatment‐resistant depression has been informed by the STAR*D programme. The 2019 PANDA trial results support the prescription of selective serotonin reuptake inhibitor antidepressants in a wider group of participants than previously thought, including those with mild to moderate symptoms who do not meet diagnostic criteria for depression or generalised anxiety disorder. Over the last two decades, ketamine, an uncompetitive N‐Methyl‐D‐Aspartate receptor antagonist and dissociative anaesthetic, has emerged as a novel and effective rapid‐acting antidepressant. Psychotic depression is an under‐identified disorder and may have a life‐time risk of up to 1%.

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The Effect of Intravenous Citalopram on the Neural Substrates of Obsessive-Compulsive Disorder

Cited by 7 publications

References 13 publications

Effects of Bergen 4-Day Treatment on Resting-State Graph Features in Obsessive-Compulsive Disorder

Effects of Bergen 4-Day Treatment on Resting-State Graph Features in Obsessive-Compulsive Disorder

Functional and Structural Neural Changes in Obsessive-compulsive Disorder after Pharmacotherapy

Depression and Anxiety Disorders

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