The effect of intravenous (IV) tranexamic acid plus buccal misoprostol on blood loss during and after cesarean delivery: a randomized double-blind study

Shady, N.W.; Farouk, H.A.; Sallam, H.F.

doi:10.36129/jog.34.01.06

Cited by 1 publication

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“…PPH stands as the major contributor to morbidity and mortality in childbirth, manifesting in approximately 1-6% of deliveries. [4] Uterine atony, responsible for 70-80% of all hemorrhagic events, emerges as the has the potential to transform an otherwise standard surgical procedure into a challenging one [8].…”

Section: Introductionmentioning

confidence: 99%

Perioperative oxytocin infusion versus tranexamic acid and ethamsylate in reducing intraoperative blood loss during caesarean section: a systematic review and meta-analysis

Adrianto,

Mangkuliguna,

Prasetyo

et al. 2024

Ital J Gynaecol Obstet

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Objective. Review the efficacy of tranexamic acid and ethamsylate (TXAEth) infusion compared to oxytocin in reducing intraoperative blood loss during caesarean section. Materials and Methods. Studies reporting TXAEth efficacy compared to oxytocin published up toNovember 24, 2023, were systematically searched across PubMed, EBSCOHost, and ProQuest.Three researchers independently extracted data. The extracted data were analysed using the MedCalc v19.5.1. Results.In this meta-analysis, three articles were assessed involving 463 participants. There was a significant mean difference in intraoperative blood loss (p = 0.030, 95%CI 0.117-2.272) and postoperative haematocrit (p = 0.004 (95%CI -8.916 to -1.710). There was no significant mean difference in the duration of surgery (p = 0.058, 95%CI -0.012-0.739) and postoperative haemoglobin (p = 0.197 (95%CI -2.026 to 0.418). Conclusions.Our studies demonstrate that using TXAEth reduced intraoperative bleeding and lowered haematocrit changes among participants. However, preoperative TXAEth has no significant advantage over the oxytocin group in terms of either the duration of surgery or postoperative haemoglobin.

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Section: Introductionmentioning

confidence: 99%