The effect of intravenous or subcutaneous administration of meglumine antimonate (glucantime<sup>®</sup>) in dogs with leishmaniasis. A randomized clinical trial

Slappendel, R.J.; Teske, Erik

doi:10.1080/01652176.1997.9694729

Cited by 40 publications

(35 citation statements)

References 5 publications

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“…Although trials measuring impact on dog infection rates are still required, the entomologic results we report strongly indicate that DM collars may be recommended to dog owners to protect their dogs from leishmaniasis. This could include dog owners traveling to leishmaniasis-endemic countries, such as in southern Europe, as imported leishmaniasis cases of dogs with a travel history to Mediterranean leishmaniasis-endemic areas are increasingly common (15,28). With the recent change in the United Kingdom quarantine laws, this is likely to be of increasing concern to British dog owners.…”

Section: Emerging Infectious Diseasesmentioning

confidence: 99%

“…However, the impact of dog-culling programs on (human and canine) ZVL incidence has been questioned on theoretical and practical grounds (10,11), and results of controlled intervention trials are contradictory (6,(12)(13)(14). Treating infected dogs with antileishmanial drugs (e.g., pentavalent antimonials, amphotericin B, aminosidine, or allopurinol) is not a practical control policy, not only because of the prohibitive cost involved but also because of high relapse rates (up to 74% [15]) among treated and clinically cured dogs. Moreover, a high proportion of clinically cured dogs remain parasitologically positive and therefore infectious to the sand fly vector (16).…”

mentioning

confidence: 99%

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Topical Insecticide Treatments to Protect Dogs from Sand Fly Vectors of Leishmaniasis

Reithinger

Teodoro

Davies

2001

Emerg. Infect. Dis.

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We compared the susceptibility of sand fly vectors to four topical insecticide treatments applied to domestic dogs, a reservoir of human leishmaniasis. Dogs were exposed to sand flies pretreatment and at 1 week, 1 month, and 2 months posttreatment. Sand fly bloodfeeding and survival rate of both fed and unfed flies were significantly reduced by the permethrin, deltamethrin, and fenthion treatments, but diazinon had no effect. The survival rate of bloodfed sand flies was reduced by up to 86% with deltamethrin collars. The antifeeding effect suggests that deltamethrin collars may be recommended to dog owners to protect their pets from sandfly-borne diseases. The combined effects on sand fly feeding and survival indicate that epidemiologic, community-based trials are warranted to test whether deltamethrin collars could reduce the incidence of canine and, hence, human leishmaniasis.

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Section: Emerging Infectious Diseasesmentioning

confidence: 99%

mentioning

confidence: 99%

Topical Insecticide Treatments to Protect Dogs from Sand Fly Vectors of Leishmaniasis

Reithinger

Teodoro

Davies

2001

Emerg. Infect. Dis.

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“…As with meglumine antimoniate and allopurinol, clinical relapses following treatment are common and side effects may also occur. Trees (2002) been found to extend survival to more than four years after the primary course of treatment in 75 per cent of cases (Slappendel and Teske 1997). The prognosis for pets with leishmaniasis can therefore be expected to be much improved when long-term intermittent treatment is administered compared with animals given only a single course of treatment.…”

Section: Diagnosismentioning

confidence: 99%

Disease risks for the travelling pet: Leishmaniasis

Trotz-Williams¹,

Gradoni²

2003

In Practice

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SINCE the introduction of the Pet Travel Scheme (PETS) in 2000, many thousands of pets have travelled between Britain and the European mainland with their owners. These animals have all been vaccinated against rabies and have also been treated for tapeworms and ticks before entering or re-entering the UK, as stipulated by DEFRA, in order to reduce the risk of importation of rabies, the zoonotic tapeworm Echinococcus species and ticks not already endemic in the UK. However, these precautions do not necessarily prevent British pets from contracting other exotic diseases while visiting countries covered by PETS, and the aim of this occasional series is to provide practical advice on the most important of these. Among the potentially fatal diseases which may be transmitted to a cat or dog, in spite of rigorous adherence to the DEFRA regulations, is leishmaniasis. This article discusses the diagnosis and treatment of this zoonotic parasitic disease in dogs and cats, and outlines some of the factors which influence the risk of transmission to the travelling pet. In doing so, it concentrates on the disease situation in Europe, while noting that, with the recent extension of PETS to North America, the picture is constantly evolving.

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“…Treatment also reduces the parasite load and the transmission of the parasite to sand flies . Slappendel and Teske (1997) found that 32(s) out of 42 (n) dogs with clinical leishmaniosis recovered from the clinical stage. Similarly, Manna et al (2008) found that 11(s) out of 18(n) patients recovered from the clinical stage.…”

Section: Treatment Efficacymentioning

confidence: 99%

Data collection to characterise the impact of canine leishmaniosis and modelling of the role of animals in spreading Leishmania infantum within the European Union

Mattin

Brodbelt

Wylie

et al. 2014

EFSA Supporting Publications

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Canine leishmaniosis (CanL) is a major zoonosis transmitted by sand flies which can potentially cause severe fatal disease in humans and dogs. The disease is endemic in southern Europe and there are concerns about its introduction into the non-endemic areas of the European Union (EU). The objectives of this work were to investigate the efficacy of different control measures using a systematic review (SR), assess the role of dogs in the spread of Leishmania Infantum (L. infantum) in the EU and evaluate potential mitigation measures using simulation modelling, and evaluate the impact of the disease in endemic areas. The SR evaluated the effectiveness and safety of control measures for CanL using 23 clinical trials conducted on a total of 5861 dogs. Significant benefits were observed in the intervention groups for a number of vaccine types, deltamethrin collars, spot-ons, and prophylactic medication with domperidone. However, these results require confirmation in adequately powered well designed randomised controlled trials. The results of the stochastic simulation modelling suggest that there is a high risk of endemicity for disease-free EU regions with presence of a competent vector and where infected dogs are introduced. When evaluated individually and at a high level of implementation, the best mitigation measures in decreasing order of effectiveness were: repellent, vaccine, prophylactic medication and insecticide. Some combinations of mitigation measures showed a joint effect higher than the effect of individual measures. Test and exclusion of positive dogs moving into non-endemic areas was effective for low numbers of imports, but its benefits diminished as the number of imported dogs increased, given the low sensitivity of the diagnostic test used. The results of the impact assessment suggest clinical CanL is a common diagnosis in endemic parts of the EU. The estimated percentage of practice-attending dogs with a veterinary diagnosis of CanL by country was as follows: France 0.71%, Spain 3.71%, Portugal 2.92%, Italy 4.25% and Greece 7.80%. CanL can have a significant impact on the welfare of affected dogs and economic implications for owners, both for prevention and treatment. It is estimated that the use of preventative collars in these five countries cost dog owners €54 million in 2012 alone. The incidence of clinical human leishmaniosis is much lower than CanL, with reported data suggesting between 20 and 380 hospital admissions per country per year. Costs relating to hospital fees and time off work may amount to approximately €4.5million/year in Spain, Portugal, Italy and Greece. The current economic crisis is likely to have an adverse impact on the prevention and control of CanL.

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The effect of intravenous or subcutaneous administration of meglumine antimonate (glucantime^®) in dogs with leishmaniasis. A randomized clinical trial

Cited by 40 publications

References 5 publications

Topical Insecticide Treatments to Protect Dogs from Sand Fly Vectors of Leishmaniasis

Topical Insecticide Treatments to Protect Dogs from Sand Fly Vectors of Leishmaniasis

Disease risks for the travelling pet: Leishmaniasis

Data collection to characterise the impact of canine leishmaniosis and modelling of the role of animals in spreading Leishmania infantum within the European Union

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The effect of intravenous or subcutaneous administration of meglumine antimonate (glucantime®) in dogs with leishmaniasis. A randomized clinical trial

Cited by 40 publications

References 5 publications

Topical Insecticide Treatments to Protect Dogs from Sand Fly Vectors of Leishmaniasis

Topical Insecticide Treatments to Protect Dogs from Sand Fly Vectors of Leishmaniasis

Disease risks for the travelling pet: Leishmaniasis

Data collection to characterise the impact of canine leishmaniosis and modelling of the role of animals in spreading Leishmania infantum within the European Union

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Product

Resources

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The effect of intravenous or subcutaneous administration of meglumine antimonate (glucantime^®) in dogs with leishmaniasis. A randomized clinical trial