The Effect of Intravenous Papaverine Hydrochloride on the Cerebral Circulation 12

Jayne, Harold W.; Scheinberg, Peritz; Rich, M.; Belle, Martin S.; Blackburn, I.

doi:10.1172/jci102568

Cited by 68 publications

(10 citation statements)

References 10 publications

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“…Administered intra venously in doses of 0.2 g to 18 patients, it caused a mean 13% increase in CBF (Jayne et al, 1952). This dose is comparable with those used in the present experiments.…”

Section: Discussionsupporting

confidence: 75%

Effects of Anoxia on Cerebral Blood Flow in the Rat Brain: Evidence for a Role of Adenosine in Autoregulation

Phillis

Preston

DeLong

1984

J Cereb Blood Flow Metab

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Summary: The purpose of these experiments was to de termine the utility of a new method for monitoring CBF using a venous outflow technique with an extracorporeal circulation and to examine the effects of agents that po tentiate or antagonize the actions of adenosine on the blood flow response to brief periods of anoxia. The re sults demonstrate the ability of the new technique to de tect the increases in CBF in response to anoxia. Caffeine, CBF is able to respond rapidly and appropriately to alterations in arterial blood pressure and brain metabolism. The mechanisms responsible for this autoregulation remain controversial, but a consid erable volume of evidence supports the hypothesis that adenosine plays a significant role in the regu lation of cerebral vascular tone. Adenosine is pro duced in the brain during hypoxia, ischemia, hy potension, and seizures (Berne et aI. , 1974; N ord strom et aI. , 1977; Winn et aI. , 1979 Winn et aI. , , 1980 Schrader et aI. , 1980). When applied directly to ce rebral vessels, adenosine causes vasodilatation (Berne et aI. , 1974;Wahl and Kuschinsky, 1976), though the effects of intraarterially perfused aden osine on CBF vary between species (Buyanski and Rapela, 1969; Berne et aI. , 1974; Heistad et aI. , 1981). The frequent failure of intraarterial adeno sine to affect CBF may be a result of its inability to readily cross the blood-brain barrier (Berne et aI. , 1974).In this study, we have used a venous outt1ow technique to measure CBF and its response to brief periods of anoxia. The method for measuring CBF by cannulation of the retroglenoid (postglenoid) vein was initially described by Gjedde et al. (1975) and by Nilsson and colleagues (Nilsson and Siesjo, 586an adenosine antagonist, reduced the intensity and du ration of the anoxia-induced hyperemia. Dipyridamole and papaverine, inhibitors of adenosine uptake, poten tiated the increase in CBF during anoxia. The results support the hypothesis that adenosine plays an important role in regulating CBF during anoxic episodes. Key Words: Anoxia-Caffeine-Cerebral blood flow-Di pyridamole-Papaverine. 1976; Hardebo et aI. , 1979). Winn et al. (1983) sub sequently adapted the technique for continuous re cording of CBF using an extracorporeal circulation with return of cerebral blood through a femoral vein. We have used this latter adaptation of the technique, which has the advantage of allowing for the continuous recording of a major fraction of the CBF over periods of several hours, during which time manipUlations of blood gases can be conducted in the presence or absence of pharmacological agents. The results of our study offer further evi dence that adenosine is an important regulator of CBF in animals challenged by anoxic episodes. METHODS PreparationCBF measurements were performed on male Sprague Dawley rats (Charles River) (weight 350-400 g). Anes thesia was induced with 2-3% halothane to allow trache otomy, and the animals were then maintained during sur gery on a mixture of nitrogen (70%), oxygen (30%), and methoxyflu...

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“…Administered intra venously in doses of 0.2 g to 18 patients, it caused a mean 13% increase in CBF (Jayne et al, 1952). This dose is comparable with those used in the present experiments.…”

Section: Discussionsupporting

confidence: 75%

Effects of Anoxia on Cerebral Blood Flow in the Rat Brain: Evidence for a Role of Adenosine in Autoregulation

Phillis

Preston

DeLong

1984

J Cereb Blood Flow Metab

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“…Thus it is possible that in the experiments with isoproterenol in the present study, the unchanged PvrOz conceals a concomitant rise in blood flow and oxygen consumption in the retina. There is no obvious reason to suspect that the other drugs used in the present study change the metabolic rate of the retina; cerebral oxygen consumption has been shown to be unaffected by administrations of norepinephrine (King, Sokoloff & Wechsler 1952), papaverine (Jayne et al 1952), histamine (Shenkin 1952) and nicotinic acid (Scheinberg 1950), while there seem to be no reports on the effect of angiotensin, xanthinol nicotinate, or dihydroergotamine on cerebral or retinal metabolism. Thus it is likely that, with the possible exception of isoproterenol, the retinal blood flow response to the injected drugs was similar to that of PvroP…”

Section: P Vr02 and Retinal Blood Flowmentioning

confidence: 72%

Effects of Norepinephrine, Angiotensin, Dihydroergotamine, Papaverine, Isoproterenol, Histamine, Nicotinic Acid, and Xanthinol Nicotinate on Retinal Oxygen Tension in Cats

Alm

1972

Acta Ophthalmologica

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The oxygen tension in the vitreous body close to the retina, P,,02, was determined continuously in cats. The effects on Pvr02 of intraarterial injections of various vasoactive drugs were determined. The vasoconstrictors norepinephrine, angiotensin and dihydroergotamine did not change PvrOZ in five cats. The same result was obtained with the vasodilators isoproterenol, histamine and xanthinol nicotinate in five cats, and with nicotinic acid in six cats, while papaverine invariably increased Pvro2 in seven cats when injected intraarterially and in two cats when injected intravenously. It is suggested that the ability to penetrate the blood-retinal barrier may play an important role in determining the effect of vasoactive drugs on retinal blood flow.

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“…Jayne and his colleagues 12 found that 120 mg of intravenous papaverine in a normal man would, in 20 minutes, increase cerebral blood flow 13% as measured by the Kety-Schmidt method. The same was reported by Aizawa et al 18 McHenry and his colleagues" reported that intravenous papaverine in seven patients with focal intracranial vascular lesions produced an 18% increase in mean cerebral blood flow and a significant increase in regional blood flow over the ischemic area.…”

Section: Discussionmentioning

confidence: 99%

Papaverine Hydrochloride and Experimental Hemorrhagic Cerebral Arterial Spasm

Kuwayama

Zervas

Shintani

et al. 1972

Stroke

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PapaverineHydrochloride and Experimental Hemorrhagic Cerebral A rterial Spasm• Chronic hemorrhagic spasm of the basilar artery was produced in beagle dogs by introducing blood into the cisterna magna. Spasm was evaluated by means of vertebral angiography. Papaverine hydrochloride was administered intravenously, intracisternally as well as intra-arterially. The intracisternal route was the more effective in combating spasm but the effect was transitory. The results suggest that the treatment of spasm by chemical means in subarachnoid hemorrhage using agents currently available would require continuous topical application.

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The Effect of Intravenous Papaverine Hydrochloride on the Cerebral Circulation 12

Cited by 68 publications

References 10 publications

Effects of Anoxia on Cerebral Blood Flow in the Rat Brain: Evidence for a Role of Adenosine in Autoregulation

Effects of Anoxia on Cerebral Blood Flow in the Rat Brain: Evidence for a Role of Adenosine in Autoregulation

Effects of Norepinephrine, Angiotensin, Dihydroergotamine, Papaverine, Isoproterenol, Histamine, Nicotinic Acid, and Xanthinol Nicotinate on Retinal Oxygen Tension in Cats

Papaverine Hydrochloride and Experimental Hemorrhagic Cerebral Arterial Spasm

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